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Urokinase-plasminogen-activator levels and prognosis in 69 soft-tissue sarcomas

Choong, Peter F.M. ; Fernö, Mårten LU ; Åkermans, Mans ; Willëm, Helena ; Lånoström, Eva ; Gustafson, Pelle LU ; Alvegård, Thor LU and Rydholm, Anders LU (1996) In International Journal of Cancer 69(4). p.268-272
Abstract

The local and systemic invasiveness of soft-tissue sarcomas may depend upon an interaction between the primary tumour and the extracellular matrix in which the proteolytic enzyme, urokinase plasminogen activator (uPA), may have an important role. We analyzed the expression of uPA in soft-tissue sarcoma using a luminescent immunoassay technique; and examined the relationships between different uPA levels and tumour characteristics and behaviour. We evaluated 69 adult patients with surgically treated soft-tissue sarcomas (MFH 43, leiomyosarcoma 8, liposarcoma 5, synovial sarcoma 4, others 9) of the extremities and trunk wall. Sixteen developed local recurrences, 26 developed metastases, and 5 had both. The median follow-up for survivors... (More)

The local and systemic invasiveness of soft-tissue sarcomas may depend upon an interaction between the primary tumour and the extracellular matrix in which the proteolytic enzyme, urokinase plasminogen activator (uPA), may have an important role. We analyzed the expression of uPA in soft-tissue sarcoma using a luminescent immunoassay technique; and examined the relationships between different uPA levels and tumour characteristics and behaviour. We evaluated 69 adult patients with surgically treated soft-tissue sarcomas (MFH 43, leiomyosarcoma 8, liposarcoma 5, synovial sarcoma 4, others 9) of the extremities and trunk wall. Sixteen developed local recurrences, 26 developed metastases, and 5 had both. The median follow-up for survivors was 55 (30-80) months. The median uPA level was 1.4 (0.04-10.6) ng/mg protein. Increasing uPA levels correlated with increasing grade, malignant fibrous histiocytomas, leiomyosarcomas, DNA non-diploidy, tumour necrosis, local recurrence, and metastasis. Storiform-pleomorphic MFH had higher uPA levels than the myxoid variant. A cut-off value of 0.25 ng/mg protein was identified, above which local recurrence and metastasis occurred more frequently. High uPA levels appear to reflect the malignant phenotype in soft-tissue sarcoma, thus supporting the role of uPA as a prognostic indicator.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
69
issue
4
pages
5 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:8797866
  • scopus:0029800492
ISSN
0020-7136
DOI
10.1002/(SICI)1097-0215(19960822)69:4<268::AID-IJC5>3.0.CO;2-V
language
English
LU publication?
no
id
cf72f57d-97b9-48e3-ad52-32ced97c1b05
date added to LUP
2019-05-25 07:53:34
date last changed
2024-03-03 11:11:52
@article{cf72f57d-97b9-48e3-ad52-32ced97c1b05,
  abstract     = {{<p>The local and systemic invasiveness of soft-tissue sarcomas may depend upon an interaction between the primary tumour and the extracellular matrix in which the proteolytic enzyme, urokinase plasminogen activator (uPA), may have an important role. We analyzed the expression of uPA in soft-tissue sarcoma using a luminescent immunoassay technique; and examined the relationships between different uPA levels and tumour characteristics and behaviour. We evaluated 69 adult patients with surgically treated soft-tissue sarcomas (MFH 43, leiomyosarcoma 8, liposarcoma 5, synovial sarcoma 4, others 9) of the extremities and trunk wall. Sixteen developed local recurrences, 26 developed metastases, and 5 had both. The median follow-up for survivors was 55 (30-80) months. The median uPA level was 1.4 (0.04-10.6) ng/mg protein. Increasing uPA levels correlated with increasing grade, malignant fibrous histiocytomas, leiomyosarcomas, DNA non-diploidy, tumour necrosis, local recurrence, and metastasis. Storiform-pleomorphic MFH had higher uPA levels than the myxoid variant. A cut-off value of 0.25 ng/mg protein was identified, above which local recurrence and metastasis occurred more frequently. High uPA levels appear to reflect the malignant phenotype in soft-tissue sarcoma, thus supporting the role of uPA as a prognostic indicator.</p>}},
  author       = {{Choong, Peter F.M. and Fernö, Mårten and Åkermans, Mans and Willëm, Helena and Lånoström, Eva and Gustafson, Pelle and Alvegård, Thor and Rydholm, Anders}},
  issn         = {{0020-7136}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{4}},
  pages        = {{268--272}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Urokinase-plasminogen-activator levels and prognosis in 69 soft-tissue sarcomas}},
  url          = {{http://dx.doi.org/10.1002/(SICI)1097-0215(19960822)69:4<268::AID-IJC5>3.0.CO;2-V}},
  doi          = {{10.1002/(SICI)1097-0215(19960822)69:4<268::AID-IJC5>3.0.CO;2-V}},
  volume       = {{69}},
  year         = {{1996}},
}