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Acoustop horesis pre-alignment of cells enables labelfree enrichment of prostate cancer cells in blood

Augustsson, P. ; Magnusson, C ; Lilja, H. LU orcid and Laurell, T. LU (2012) 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 p.1696-1698
Abstract

We have developed a microfluidic chip for isolation of circulating tumor cells (CTCs) in blood based on microchannel acoustophoresis. Ultrasound radiation forces are used to separate cancer cells from blood cells in a continuous flow format. Separation was dramatically improved after incorporation of a 2-dimensional acoustic pre-alignment of the cells before entering the acoustophoresis separation channel. Temperature regulation of the microfluidic chip (±0.5?C) enabled stable and reproducible separation. The chip constitutes a further development and refinement of methods previously presented by our group at μTAS [1-3].

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author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Blood cells, Circulating tumor cells, Separation, Ultrasound
host publication
Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
series title
Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
pages
1696 - 1698
publisher
Chemical and Biological Microsystems Society
conference name
16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
conference location
Okinawa, Japan
conference dates
2012-10-28 - 2012-11-01
external identifiers
  • scopus:84901760395
ISBN
9780979806452
language
English
LU publication?
yes
id
d020c23a-8f05-4383-8881-5956354ac442
date added to LUP
2023-02-10 11:15:30
date last changed
2023-11-24 13:46:38
@inproceedings{d020c23a-8f05-4383-8881-5956354ac442,
  abstract     = {{<p>We have developed a microfluidic chip for isolation of circulating tumor cells (CTCs) in blood based on microchannel acoustophoresis. Ultrasound radiation forces are used to separate cancer cells from blood cells in a continuous flow format. Separation was dramatically improved after incorporation of a 2-dimensional acoustic pre-alignment of the cells before entering the acoustophoresis separation channel. Temperature regulation of the microfluidic chip (±0.5?C) enabled stable and reproducible separation. The chip constitutes a further development and refinement of methods previously presented by our group at μTAS [1-3].</p>}},
  author       = {{Augustsson, P. and Magnusson, C and Lilja, H. and Laurell, T.}},
  booktitle    = {{Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012}},
  isbn         = {{9780979806452}},
  keywords     = {{Blood cells; Circulating tumor cells; Separation; Ultrasound}},
  language     = {{eng}},
  pages        = {{1696--1698}},
  publisher    = {{Chemical and Biological Microsystems Society}},
  series       = {{Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012}},
  title        = {{Acoustop horesis pre-alignment of cells enables labelfree enrichment of prostate cancer cells in blood}},
  year         = {{2012}},
}