Acoustop horesis pre-alignment of cells enables labelfree enrichment of prostate cancer cells in blood
(2012) 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 p.1696-1698- Abstract
We have developed a microfluidic chip for isolation of circulating tumor cells (CTCs) in blood based on microchannel acoustophoresis. Ultrasound radiation forces are used to separate cancer cells from blood cells in a continuous flow format. Separation was dramatically improved after incorporation of a 2-dimensional acoustic pre-alignment of the cells before entering the acoustophoresis separation channel. Temperature regulation of the microfluidic chip (±0.5?C) enabled stable and reproducible separation. The chip constitutes a further development and refinement of methods previously presented by our group at μTAS [1-3].
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https://lup.lub.lu.se/record/d020c23a-8f05-4383-8881-5956354ac442
- author
- Augustsson, P. ; Magnusson, C ; Lilja, H. LU and Laurell, T. LU
- organization
- publishing date
- 2012
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Blood cells, Circulating tumor cells, Separation, Ultrasound
- host publication
- Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
- series title
- Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
- pages
- 1696 - 1698
- publisher
- Chemical and Biological Microsystems Society
- conference name
- 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
- conference location
- Okinawa, Japan
- conference dates
- 2012-10-28 - 2012-11-01
- external identifiers
-
- scopus:84901760395
- ISBN
- 9780979806452
- language
- English
- LU publication?
- yes
- id
- d020c23a-8f05-4383-8881-5956354ac442
- date added to LUP
- 2023-02-10 11:15:30
- date last changed
- 2023-11-24 13:46:38
@inproceedings{d020c23a-8f05-4383-8881-5956354ac442, abstract = {{<p>We have developed a microfluidic chip for isolation of circulating tumor cells (CTCs) in blood based on microchannel acoustophoresis. Ultrasound radiation forces are used to separate cancer cells from blood cells in a continuous flow format. Separation was dramatically improved after incorporation of a 2-dimensional acoustic pre-alignment of the cells before entering the acoustophoresis separation channel. Temperature regulation of the microfluidic chip (±0.5?C) enabled stable and reproducible separation. The chip constitutes a further development and refinement of methods previously presented by our group at μTAS [1-3].</p>}}, author = {{Augustsson, P. and Magnusson, C and Lilja, H. and Laurell, T.}}, booktitle = {{Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012}}, isbn = {{9780979806452}}, keywords = {{Blood cells; Circulating tumor cells; Separation; Ultrasound}}, language = {{eng}}, pages = {{1696--1698}}, publisher = {{Chemical and Biological Microsystems Society}}, series = {{Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012}}, title = {{Acoustop horesis pre-alignment of cells enables labelfree enrichment of prostate cancer cells in blood}}, year = {{2012}}, }