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Acoustophoresis separation of bacteria from blood cells for rapid sepsis diagnostics

Ohlsson, P. D. LU orcid ; Petersson, K. LU ; Augustsson, P. LU and Laurell, T. LU (2013) 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 2. p.1320-1322
Abstract

We present a significantly improved acoustophoresis method to separate bacteria from red and white blood cells. As much as 98% of the bacteria were recovered, while only 0.06 % of the red and white blood cells remained. This 1600-fold relative enrichment was achieved by adjusting the center medium density, tightly controlling the chip temperature and stabilizing the fluid flows. This is a crucial sample preparation step facilitating downstream bacteria identification for sepsis diagnostics.

Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Acoustophoresis, Bacteria, Blood, Sepsis
host publication
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
volume
2
pages
3 pages
publisher
Chemical and Biological Microsystems Society
conference name
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
conference location
Freiburg, Germany
conference dates
2013-10-27 - 2013-10-31
external identifiers
  • scopus:84907358599
ISBN
9781632666246
language
English
LU publication?
yes
id
d060ebb4-ab6d-4c47-965a-9188673c4049
date added to LUP
2017-12-06 15:17:22
date last changed
2025-10-14 13:19:48
@inproceedings{d060ebb4-ab6d-4c47-965a-9188673c4049,
  abstract     = {{<p>We present a significantly improved acoustophoresis method to separate bacteria from red and white blood cells. As much as 98% of the bacteria were recovered, while only 0.06 % of the red and white blood cells remained. This 1600-fold relative enrichment was achieved by adjusting the center medium density, tightly controlling the chip temperature and stabilizing the fluid flows. This is a crucial sample preparation step facilitating downstream bacteria identification for sepsis diagnostics.</p>}},
  author       = {{Ohlsson, P. D. and Petersson, K. and Augustsson, P. and Laurell, T.}},
  booktitle    = {{17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013}},
  isbn         = {{9781632666246}},
  keywords     = {{Acoustophoresis; Bacteria; Blood; Sepsis}},
  language     = {{eng}},
  pages        = {{1320--1322}},
  publisher    = {{Chemical and Biological Microsystems Society}},
  title        = {{Acoustophoresis separation of bacteria from blood cells for rapid sepsis diagnostics}},
  volume       = {{2}},
  year         = {{2013}},
}