Advanced

Circulating metabolites associated with alcohol intake in the european prospective investigation into cancer and nutrition cohort

van Roekel, Eline H.; Trijsburg, Laura; Assi, Nada; Carayol, Marion; Achaintre, David; Murphy, Neil; Rinaldi, Sabina; Schmidt, Julie A.; Stepien, Magdalena and Kaaks, Rudolf, et al. (2018) In Nutrients 10(5).
Abstract

Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTMp180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol... (More)

Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTMp180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption withmetabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acylcarnitines, Alcohol, Amino acids, Lipid metabolites, Targeted metabolomics
in
Nutrients
volume
10
issue
5
publisher
MDPI AG
external identifiers
  • scopus:85047641243
ISSN
2072-6643
DOI
language
English
LU publication?
yes
id
d06560b3-4e27-4510-aefa-7f6430e7b789
date added to LUP
2018-06-13 14:25:34
date last changed
2018-06-14 03:00:06
@article{d06560b3-4e27-4510-aefa-7f6430e7b789,
  abstract     = {<p>Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTMp180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption withmetabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value &lt; 0.05) were further tested in the replication set (Bonferroni-corrected p-value &lt; 0.05). Of the 72metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.</p>},
  articleno    = {654},
  author       = {van Roekel, Eline H. and Trijsburg, Laura and Assi, Nada and Carayol, Marion and Achaintre, David and Murphy, Neil and Rinaldi, Sabina and Schmidt, Julie A. and Stepien, Magdalena and Kaaks, Rudolf and Kühn, Tilman and Boeing, Heiner and Iqbal, Khalid and Palli, Domenico and Krogh, Vittorio and Tumino, Rosario and Ricceri, Fulvio and Panico, Salvatore and Peeters, Petra H. and Bueno-de-Mesquita, Bas and Ardanaz, Eva and Lujan-Barroso, Leila and Quirós, J. Ramón and Huerta, José M. and Molina-Portillo, Elena and Dorronsoro, Miren and Tsilidis, Konstantinos K. and Riboli, Elio and Rostgaard-Hansen, Agnetha Linn and Tjønneland, Anne and Overvad, Kim and Weiderpass, Elisabete and Boutron-Ruault, Marie Christine and Severi, Gianluca and Trichopoulou, Antonia and Karakatsani, Anna and Kotanidou, Anastasia and Håkansson, Anders and Malm, Johan and Weijenberg, Matty P. and Gunter, Marc J. and Jenab, Mazda and Johansson, Mattias and Travis, Ruth C. and Scalbert, Augustin and Ferrari, Pietro},
  issn         = {2072-6643},
  keyword      = {Acylcarnitines,Alcohol,Amino acids,Lipid metabolites,Targeted metabolomics},
  language     = {eng},
  month        = {05},
  number       = {5},
  publisher    = {MDPI AG},
  series       = {Nutrients},
  title        = {Circulating metabolites associated with alcohol intake in the european prospective investigation into cancer and nutrition cohort},
  url          = {http://dx.doi.org/},
  volume       = {10},
  year         = {2018},
}