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Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5-15-Year-Old Children Followed in the TEDDY Study

Liu, Xiang ; Johnson, Suzanne Bennett LU ; Lynch, Kristian F LU ; Cordan, Kerry ; Pate, Russell ; Butterworth, Martha D ; Lernmark, Åke LU orcid ; Hagopian, William A ; Rewers, Marian J and McIndoe, Richard A , et al. (2023) In Diabetes Care 46(7). p.1409-1416
Abstract

OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years.

RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of Diabetes in the Young (TEDDY) study, annual assessment of activity using accelerometry was conducted from age 5 years. Time-to-event analyses using Cox proportional hazard models were used to assess the association between time spent in moderate to vigorous physical activity per day and the appearance of one or several autoantibodies and progression to type 1 diabetes in three risk groups: 1) 3,869 islet autoantibody (IA)-negative children, of whom 157 became... (More)

OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years.

RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of Diabetes in the Young (TEDDY) study, annual assessment of activity using accelerometry was conducted from age 5 years. Time-to-event analyses using Cox proportional hazard models were used to assess the association between time spent in moderate to vigorous physical activity per day and the appearance of one or several autoantibodies and progression to type 1 diabetes in three risk groups: 1) 3,869 islet autoantibody (IA)-negative children, of whom 157 became single IA positive; 2) 302 single IA-positive children, of whom 73 became multiple-IA positive; and 3) 294 multiple IA-positive children, of whom 148 developed type 1 diabetes.

RESULTS: No significant association was found in risk group 1 or risk group 2. A significant association was seen in risk group 3 (hazard ratio 0.920 [95% CI 0.856, 0.988] per 10-min increase; P = 0.021), particularly when glutamate decarboxylase autoantibody was the first autoantibody (hazard ratio 0.883 [95% CI 0.783, 0.996] per 10-min increase; P = 0.043).

CONCLUSIONS: More daily minutes spent in moderate to vigorous physical activity was associated with a reduced risk of progression to type 1 diabetes in children aged 5-15 years who had developed multiple IAs.

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author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
46
issue
7
pages
1409 - 1416
publisher
American Diabetes Association
external identifiers
  • pmid:37141102
  • scopus:85163599708
ISSN
1935-5548
DOI
10.2337/dc23-0036
language
English
LU publication?
yes
additional info
© 2023 by the American Diabetes Association.
id
d071420d-9eb6-43fe-a47a-79ff1675d1fd
date added to LUP
2023-05-10 23:00:09
date last changed
2024-04-19 21:40:55
@article{d071420d-9eb6-43fe-a47a-79ff1675d1fd,
  abstract     = {{<p>OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years.</p><p>RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of Diabetes in the Young (TEDDY) study, annual assessment of activity using accelerometry was conducted from age 5 years. Time-to-event analyses using Cox proportional hazard models were used to assess the association between time spent in moderate to vigorous physical activity per day and the appearance of one or several autoantibodies and progression to type 1 diabetes in three risk groups: 1) 3,869 islet autoantibody (IA)-negative children, of whom 157 became single IA positive; 2) 302 single IA-positive children, of whom 73 became multiple-IA positive; and 3) 294 multiple IA-positive children, of whom 148 developed type 1 diabetes.</p><p>RESULTS: No significant association was found in risk group 1 or risk group 2. A significant association was seen in risk group 3 (hazard ratio 0.920 [95% CI 0.856, 0.988] per 10-min increase; P = 0.021), particularly when glutamate decarboxylase autoantibody was the first autoantibody (hazard ratio 0.883 [95% CI 0.783, 0.996] per 10-min increase; P = 0.043).</p><p>CONCLUSIONS: More daily minutes spent in moderate to vigorous physical activity was associated with a reduced risk of progression to type 1 diabetes in children aged 5-15 years who had developed multiple IAs.</p>}},
  author       = {{Liu, Xiang and Johnson, Suzanne Bennett and Lynch, Kristian F and Cordan, Kerry and Pate, Russell and Butterworth, Martha D and Lernmark, Åke and Hagopian, William A and Rewers, Marian J and McIndoe, Richard A and Toppari, Jorma and Ziegler, Anette-G and Akolkar, Beena and Krischer, Jeffrey P and Yang, Jimin}},
  issn         = {{1935-5548}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1409--1416}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5-15-Year-Old Children Followed in the TEDDY Study}},
  url          = {{http://dx.doi.org/10.2337/dc23-0036}},
  doi          = {{10.2337/dc23-0036}},
  volume       = {{46}},
  year         = {{2023}},
}