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Rearrangement of the neoplasia-associated gene HMGIC in synovia from patients with osteoarthritis

Broberg, K LU ; Höglund, M LU ; Limon, J; Lindstrand, A LU ; Toksvig-Larsen, S LU ; Mandahl, N LU and Mertens, F LU (1999) In Genes, Chromosomes and Cancer 24(3). p.82-278
Abstract

The occurrence of clonal chromosome aberrations in short-term cultures from synovia, osteophytes, and cartilage from patients with osteoarthritis (OA) was recently reported. Among these aberrations, a recurrent involvement of chromosome bands 12q13-15 in structural rearrangements was detected in both synovia and osteophytes. Chromosomal abnormalities of 12q13-15 are frequent among malignant and benign mesenchymal tumors, and it was recently demonstrated that the molecular target in these neoplasms is the HMGIC gene. In this study, we show by fluorescence in situ hybridization that HMGIC was disrupted by rearrangements of 12q15 in synovia from two patients with OA. The finding of HMGIC rearrangement in a lesion that is not traditionally... (More)

The occurrence of clonal chromosome aberrations in short-term cultures from synovia, osteophytes, and cartilage from patients with osteoarthritis (OA) was recently reported. Among these aberrations, a recurrent involvement of chromosome bands 12q13-15 in structural rearrangements was detected in both synovia and osteophytes. Chromosomal abnormalities of 12q13-15 are frequent among malignant and benign mesenchymal tumors, and it was recently demonstrated that the molecular target in these neoplasms is the HMGIC gene. In this study, we show by fluorescence in situ hybridization that HMGIC was disrupted by rearrangements of 12q15 in synovia from two patients with OA. The finding of HMGIC rearrangement in a lesion that is not traditionally regarded as neoplastic not only widens the spectrum of disorders that may be associated with altered function of this gene, but also provides further support for the notion that genetically rearranged cell populations are part of the OA process.

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keywords
Aged, Cells, Cultured, Chromosomes, Human, Pair 12/genetics, Female, HMGA2 Protein, High Mobility Group Proteins/genetics, Humans, In Situ Hybridization, Fluorescence, Karyotyping, Male, Middle Aged, Neoplasm Proteins/genetics, Osteoarthritis/genetics, Synovial Membrane/chemistry, Translocation, Genetic/genetics
in
Genes, Chromosomes and Cancer
volume
24
issue
3
pages
82 - 278
publisher
John Wiley & Sons
external identifiers
  • scopus:0344141256
ISSN
1045-2257
language
English
LU publication?
yes
id
d07ec603-a011-4c41-84f9-af3ffa241815
alternative location
https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291098-2264%28199903%2924%3A3%3C278%3A%3AAID-GCC14%3E3.0.CO%3B2-L?sid=Entrez%3APubMed
date added to LUP
2019-02-08 13:59:19
date last changed
2019-02-11 09:06:24
@article{d07ec603-a011-4c41-84f9-af3ffa241815,
  abstract     = {<p>The occurrence of clonal chromosome aberrations in short-term cultures from synovia, osteophytes, and cartilage from patients with osteoarthritis (OA) was recently reported. Among these aberrations, a recurrent involvement of chromosome bands 12q13-15 in structural rearrangements was detected in both synovia and osteophytes. Chromosomal abnormalities of 12q13-15 are frequent among malignant and benign mesenchymal tumors, and it was recently demonstrated that the molecular target in these neoplasms is the HMGIC gene. In this study, we show by fluorescence in situ hybridization that HMGIC was disrupted by rearrangements of 12q15 in synovia from two patients with OA. The finding of HMGIC rearrangement in a lesion that is not traditionally regarded as neoplastic not only widens the spectrum of disorders that may be associated with altered function of this gene, but also provides further support for the notion that genetically rearranged cell populations are part of the OA process.</p>},
  author       = {Broberg, K and Höglund, M and Limon, J and Lindstrand, A and Toksvig-Larsen, S and Mandahl, N and Mertens, F},
  issn         = {1045-2257},
  keyword      = {Aged,Cells, Cultured,Chromosomes, Human, Pair 12/genetics,Female,HMGA2 Protein,High Mobility Group Proteins/genetics,Humans,In Situ Hybridization, Fluorescence,Karyotyping,Male,Middle Aged,Neoplasm Proteins/genetics,Osteoarthritis/genetics,Synovial Membrane/chemistry,Translocation, Genetic/genetics},
  language     = {eng},
  number       = {3},
  pages        = {82--278},
  publisher    = {John Wiley & Sons},
  series       = {Genes, Chromosomes and Cancer},
  title        = {Rearrangement of the neoplasia-associated gene HMGIC in synovia from patients with osteoarthritis},
  volume       = {24},
  year         = {1999},
}