Fast simulation of pharmacokinetics
Wahlquist, Ylva LU ; Bagge Carlson, Fredrik LU and Soltesz, Kristian LU
(2023)
22nd IFAC World Congress
In IFAC Proceedings Volumes (IFAC-PapersOnline)
56(2).
p.2995-3000
- Abstract
- Fast simulation of linear time-invariant (LTI) pharmacokinetic (PK) models is crucial to mixed-effect modeling techniques, used extensively in pharmacological research and development. The by far most common LTI PK models are particularly structured compartmental systems with one, two or three compartments. Here we develop and demonstrate very efficient, and down to machine precision exact, simulators for those structures. Our proposed method is benchmarked against state-of-the art software for simulation of linear systems, using a clinically relevant data set.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/d091ba04-0819-4d6b-8e27-3accb1a16795
- author
- Wahlquist, Ylva
LU
; Bagge Carlson, Fredrik
LU
and Soltesz, Kristian
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- IFAC Proceedings Volumes (IFAC-PapersOnline)
- volume
- 56
- issue
- 2
- pages
- 2995 - 3000
- publisher
- IFAC Secretariat
- conference name
- 22nd IFAC World Congress
- conference location
- Yokohama, Japan
- conference dates
- 2023-07-09 - 2023-07-14
- external identifiers
-
- scopus:85174574506
- ISSN
- 2405-8963
- DOI
- 10.1016/j.ifacol.2023.10.1425
- project
- Learning pharmacometric model structures from data
- language
- English
- LU publication?
- yes
- id
- d091ba04-0819-4d6b-8e27-3accb1a16795
- date added to LUP
- 2023-03-04 14:21:29
- date last changed
- 2024-03-29 04:01:08
@article{d091ba04-0819-4d6b-8e27-3accb1a16795,
abstract = {{Fast simulation of linear time-invariant (LTI) pharmacokinetic (PK) models is crucial to mixed-effect modeling techniques, used extensively in pharmacological research and development. The by far most common LTI PK models are particularly structured compartmental systems with one, two or three compartments. Here we develop and demonstrate very efficient, and down to machine precision exact, simulators for those structures. Our proposed method is benchmarked against state-of-the art software for simulation of linear systems, using a clinically relevant data set.}},
author = {{Wahlquist, Ylva and Bagge Carlson, Fredrik and Soltesz, Kristian}},
issn = {{2405-8963}},
language = {{eng}},
number = {{2}},
pages = {{2995--3000}},
publisher = {{IFAC Secretariat}},
series = {{IFAC Proceedings Volumes (IFAC-PapersOnline)}},
title = {{Fast simulation of pharmacokinetics}},
url = {{http://dx.doi.org/10.1016/j.ifacol.2023.10.1425}},
doi = {{10.1016/j.ifacol.2023.10.1425}},
volume = {{56}},
year = {{2023}},
}