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Immature neural tissue grafts in Parkinson's disease

Widner, H LU (1993) In Acta neurologica Scandinavica. Supplementum 146. p.5-43
Abstract

Intracerebral transplantation of immature neural tissue is a promising therapeutical approach that has the potential of restoring damaged neuronal circuitries and reversing functional deficits. The development of the technique as a human application has progressed the furthest in Parkinson's disease (PD), with the demonstration of significant longlasting functional improvements, in combination with evidence of surviving grafted tissue, using a fluorodopa positron emission tomography (PET) scanning technique in a few patients. Although the technique is promising, and the effects observed are significant and of clinical importance for the grafted patients in the best cases so far, there are still incomplete effects and no transplantation... (More)

Intracerebral transplantation of immature neural tissue is a promising therapeutical approach that has the potential of restoring damaged neuronal circuitries and reversing functional deficits. The development of the technique as a human application has progressed the furthest in Parkinson's disease (PD), with the demonstration of significant longlasting functional improvements, in combination with evidence of surviving grafted tissue, using a fluorodopa positron emission tomography (PET) scanning technique in a few patients. Although the technique is promising, and the effects observed are significant and of clinical importance for the grafted patients in the best cases so far, there are still incomplete effects and no transplantation treatment is suggested since there are still several technical aspects that might further improve the outcome. The progress of the development in the field is briefly reviewed.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Brain Tissue Transplantation, Corpus Striatum, Dopamine, Fetal Tissue Transplantation, Humans, Mesencephalon, Nerve Regeneration, Parkinson Disease, Journal Article, Review
in
Acta neurologica Scandinavica. Supplementum
volume
146
pages
3 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:0027487438
ISSN
0065-1427
language
English
LU publication?
no
id
d0a84dff-8417-4fb5-a1d7-5fc1879fa541
date added to LUP
2017-04-19 18:30:41
date last changed
2017-05-24 12:35:28
@article{d0a84dff-8417-4fb5-a1d7-5fc1879fa541,
  abstract     = {<p>Intracerebral transplantation of immature neural tissue is a promising therapeutical approach that has the potential of restoring damaged neuronal circuitries and reversing functional deficits. The development of the technique as a human application has progressed the furthest in Parkinson's disease (PD), with the demonstration of significant longlasting functional improvements, in combination with evidence of surviving grafted tissue, using a fluorodopa positron emission tomography (PET) scanning technique in a few patients. Although the technique is promising, and the effects observed are significant and of clinical importance for the grafted patients in the best cases so far, there are still incomplete effects and no transplantation treatment is suggested since there are still several technical aspects that might further improve the outcome. The progress of the development in the field is briefly reviewed.</p>},
  author       = {Widner, H},
  issn         = {0065-1427},
  keyword      = {Animals,Brain Tissue Transplantation,Corpus Striatum,Dopamine,Fetal Tissue Transplantation,Humans,Mesencephalon,Nerve Regeneration,Parkinson Disease,Journal Article,Review},
  language     = {eng},
  pages        = {5--43},
  publisher    = {Wiley-Blackwell},
  series       = {Acta neurologica Scandinavica. Supplementum},
  title        = {Immature neural tissue grafts in Parkinson's disease},
  volume       = {146},
  year         = {1993},
}