Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Impact of previous diverticulitis on 5-year survival and recurrence rates in patients with colorectal cancer

Sahli, Hannah ; Dahlbäck, Cecilia LU ; Lydrup, Marie Louise LU and Buchwald, Pamela LU (2023) In Scandinavian Journal of Gastroenterology 58(11). p.1280-1285
Abstract

Background: Diverticulitis and colorectal cancer (CRC) share epidemiological characteristics, but their relationship remains unknown. It is unclear if prognosis following CRC differ for patients with previous diverticulitis compared to those with sporadic cases and patients with inflammatory bowel disease or hereditary syndromes. Aim: The aim was to determine 5-year survival and recurrence after colorectal cancer in patients with previous diverticulitis, inflammatory bowel disease and hereditary colorectal cancer compared to sporadic cases. Methods: Patients <75 years of age diagnosed with colorectal cancer at Skåne University Hospital Malmö, Sweden, between January 1st 2012 and December 31st 2017 were... (More)

Background: Diverticulitis and colorectal cancer (CRC) share epidemiological characteristics, but their relationship remains unknown. It is unclear if prognosis following CRC differ for patients with previous diverticulitis compared to those with sporadic cases and patients with inflammatory bowel disease or hereditary syndromes. Aim: The aim was to determine 5-year survival and recurrence after colorectal cancer in patients with previous diverticulitis, inflammatory bowel disease and hereditary colorectal cancer compared to sporadic cases. Methods: Patients <75 years of age diagnosed with colorectal cancer at Skåne University Hospital Malmö, Sweden, between January 1st 2012 and December 31st 2017 were identified through the Swedish colorectal cancer registry. Data was retrieved from the Swedish colorectal cancer registry and chart review. Five-year survival and recurrence in colorectal cancer patients with previous diverticulitis were compared to sporadic cases, inflammatory bowel disease associated and hereditary colorectal cancer. Results: The study cohort comprised 1052 patients, 28 (2.7%) with previous diverticulitis, 26 (2.5%) IBD, 4 (1.3%) hereditary syndromes and 984 (93.5%) sporadic cases. Patients with a history of acute complicated diverticulitis had a significantly lower 5-year survival rate (61.1%) and higher recurrence rate (38.9%) compared to sporadic cases (87.5% and 18.8% respectively). Conclusion: Patients with acute complicated diverticulitis had worse 5-year prognosis compared to sporadic cases. The results emphasize the importance of early detection of colorectal cancer in patients with acute complicated diverticulitis.

(Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Colorectal cancer, diverticulitis, inflammatory bowel disease, lynch syndrome, oncological outcomes
in
Scandinavian Journal of Gastroenterology
volume
58
issue
11
pages
1280 - 1285
publisher
Taylor & Francis
external identifiers
  • pmid:37296500
  • scopus:85161704831
ISSN
0036-5521
DOI
10.1080/00365521.2023.2221361
language
English
LU publication?
yes
id
d0ce3041-a0c0-4800-bbc3-0d1fbc4c4251
date added to LUP
2023-10-30 10:31:22
date last changed
2024-04-19 02:59:09
@article{d0ce3041-a0c0-4800-bbc3-0d1fbc4c4251,
  abstract     = {{<p>Background: Diverticulitis and colorectal cancer (CRC) share epidemiological characteristics, but their relationship remains unknown. It is unclear if prognosis following CRC differ for patients with previous diverticulitis compared to those with sporadic cases and patients with inflammatory bowel disease or hereditary syndromes. Aim: The aim was to determine 5-year survival and recurrence after colorectal cancer in patients with previous diverticulitis, inflammatory bowel disease and hereditary colorectal cancer compared to sporadic cases. Methods: Patients &lt;75 years of age diagnosed with colorectal cancer at Skåne University Hospital Malmö, Sweden, between January 1<sup>st</sup> 2012 and December 31<sup>st</sup> 2017 were identified through the Swedish colorectal cancer registry. Data was retrieved from the Swedish colorectal cancer registry and chart review. Five-year survival and recurrence in colorectal cancer patients with previous diverticulitis were compared to sporadic cases, inflammatory bowel disease associated and hereditary colorectal cancer. Results: The study cohort comprised 1052 patients, 28 (2.7%) with previous diverticulitis, 26 (2.5%) IBD, 4 (1.3%) hereditary syndromes and 984 (93.5%) sporadic cases. Patients with a history of acute complicated diverticulitis had a significantly lower 5-year survival rate (61.1%) and higher recurrence rate (38.9%) compared to sporadic cases (87.5% and 18.8% respectively). Conclusion: Patients with acute complicated diverticulitis had worse 5-year prognosis compared to sporadic cases. The results emphasize the importance of early detection of colorectal cancer in patients with acute complicated diverticulitis.</p>}},
  author       = {{Sahli, Hannah and Dahlbäck, Cecilia and Lydrup, Marie Louise and Buchwald, Pamela}},
  issn         = {{0036-5521}},
  keywords     = {{Colorectal cancer; diverticulitis; inflammatory bowel disease; lynch syndrome; oncological outcomes}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1280--1285}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Gastroenterology}},
  title        = {{Impact of previous diverticulitis on 5-year survival and recurrence rates in patients with colorectal cancer}},
  url          = {{http://dx.doi.org/10.1080/00365521.2023.2221361}},
  doi          = {{10.1080/00365521.2023.2221361}},
  volume       = {{58}},
  year         = {{2023}},
}