MicroRNA-9-3p : a novel predictor of neurological outcome after cardiac arrest
(2022) In European Heart Journal: Acute Cardiovascular Care 11(8). p.609-616- Abstract
Aims: Resuscitated out-of-hospital cardiac arrest (OHCA) patients who remain comatose after hospital arrival are at high risk of mortality due to anoxic brain injury. MicroRNA are small-non-coding RNA molecules ultimately involved in gene-silencing. They show promise as biomarkers, as they are stable in body fluids. The microRNA 9-3p (miR-9-3p) is associated with neurological injury in trauma and subarachnoid haemorrhage. Methods and results: This post hoc analysis considered all 171 comatose OHCA patients from a single centre in the target temperature management (TTM) trial. Patients were randomized to TTM at either 33°C or 36°C for 24 h. MicroRNA-9-3p (miR-9-3p) was measured in plasma sampled at admission and at 28, 48, and 72 h.... (More)
Aims: Resuscitated out-of-hospital cardiac arrest (OHCA) patients who remain comatose after hospital arrival are at high risk of mortality due to anoxic brain injury. MicroRNA are small-non-coding RNA molecules ultimately involved in gene-silencing. They show promise as biomarkers, as they are stable in body fluids. The microRNA 9-3p (miR-9-3p) is associated with neurological injury in trauma and subarachnoid haemorrhage. Methods and results: This post hoc analysis considered all 171 comatose OHCA patients from a single centre in the target temperature management (TTM) trial. Patients were randomized to TTM at either 33°C or 36°C for 24 h. MicroRNA-9-3p (miR-9-3p) was measured in plasma sampled at admission and at 28, 48, and 72 h. There were no significant differences in age, gender, and pre-hospital data, including lactate level at admission, between miR-9-3p level quartiles. miR-9-3p levels changed markedly following OHCA with a peak at 48 h. Median miR-9-3p levels between TTM 33°C vs. 36°C were not different at any of the four time points. Elevated miR-9-3p levels at 48 h were strongly associated with an unfavourable neurological outcome [OR: 2.21, 95% confidence interval (CI): 1.64-3.15, P < 0.0001). MiR-9-3p was inferior to neuron-specific enolase in predicting functional neurological outcome [area under the curve: 0.79 (95% CI: 0.71-0.87) vs. 0.91 (95% CI: 0.85-0.97)]. Conclusion: MiR-9-3p is strongly associated with neurological outcome following OHCA, and the levels of miR-9-3p are peaking 48 hours following cardiac arrest.
(Less)
- author
- organization
- publishing date
- 2022-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cardiac arrest, Microrna, Mir-9-3p, Neurologic outcome, Out-of-hospital cardiac arrest, Prognostication
- in
- European Heart Journal: Acute Cardiovascular Care
- volume
- 11
- issue
- 8
- pages
- 8 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:35695264
- scopus:85162288807
- ISSN
- 2048-8726
- DOI
- 10.1093/ehjacc/zuac066
- language
- English
- LU publication?
- yes
- id
- d12862ea-6a43-4b3b-aff8-90c3ed65541d
- date added to LUP
- 2023-10-23 14:55:30
- date last changed
- 2024-04-19 02:45:33
@article{d12862ea-6a43-4b3b-aff8-90c3ed65541d,
abstract = {{<p>Aims: Resuscitated out-of-hospital cardiac arrest (OHCA) patients who remain comatose after hospital arrival are at high risk of mortality due to anoxic brain injury. MicroRNA are small-non-coding RNA molecules ultimately involved in gene-silencing. They show promise as biomarkers, as they are stable in body fluids. The microRNA 9-3p (miR-9-3p) is associated with neurological injury in trauma and subarachnoid haemorrhage. Methods and results: This post hoc analysis considered all 171 comatose OHCA patients from a single centre in the target temperature management (TTM) trial. Patients were randomized to TTM at either 33°C or 36°C for 24 h. MicroRNA-9-3p (miR-9-3p) was measured in plasma sampled at admission and at 28, 48, and 72 h. There were no significant differences in age, gender, and pre-hospital data, including lactate level at admission, between miR-9-3p level quartiles. miR-9-3p levels changed markedly following OHCA with a peak at 48 h. Median miR-9-3p levels between TTM 33°C vs. 36°C were not different at any of the four time points. Elevated miR-9-3p levels at 48 h were strongly associated with an unfavourable neurological outcome [OR: 2.21, 95% confidence interval (CI): 1.64-3.15, P < 0.0001). MiR-9-3p was inferior to neuron-specific enolase in predicting functional neurological outcome [area under the curve: 0.79 (95% CI: 0.71-0.87) vs. 0.91 (95% CI: 0.85-0.97)]. Conclusion: MiR-9-3p is strongly associated with neurological outcome following OHCA, and the levels of miR-9-3p are peaking 48 hours following cardiac arrest.</p>}},
author = {{Beske, Rasmus Paulin and Bache, Søren and Meyer, Martin Abild Stengaard and Kjærgaard, Jesper and Bro-Jeppesen, John and Obling, Laust and Olsen, Markus Harboe and Rossing, Maria and Nielsen, Finn Cilius and Møller, Kirsten and Nielsen, Niklas and Hassager, Christian}},
issn = {{2048-8726}},
keywords = {{Cardiac arrest; Microrna; Mir-9-3p; Neurologic outcome; Out-of-hospital cardiac arrest; Prognostication}},
language = {{eng}},
number = {{8}},
pages = {{609--616}},
publisher = {{Oxford University Press}},
series = {{European Heart Journal: Acute Cardiovascular Care}},
title = {{MicroRNA-9-3p : a novel predictor of neurological outcome after cardiac arrest}},
url = {{http://dx.doi.org/10.1093/ehjacc/zuac066}},
doi = {{10.1093/ehjacc/zuac066}},
volume = {{11}},
year = {{2022}},
}