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Soft tissue tumors

Mandahl, Nils LU and Mertens, Fredrik LU (2015) In Cancer Cytogenetics p.583-614
Abstract

Soft tissue tumors are highly heterogeneous with more than 100 subtypes. The chapter describes a large number of fibroblastic/myofibroblastic tumor entities. Alveolar rhabdomyosarcomas (ARMS) and embryonal rhabdomyosarcomas (ERMS) show largely similar patterns of genomic imbalances, although most of them occur at higher frequencies among the latter. The chromosome numbers of 70 undifferentiated pleomorphic sarcomas varied from near haploidy to hyperoctaploidy. Cytogenetic analyses have revealed that practically all soft tissue tumor types harbor acquired chromosome aberrations. The type of aberrations and the level of karyotypic complexity vary considerably from one tumor entity to another. At one end are the pathognomonic... (More)

Soft tissue tumors are highly heterogeneous with more than 100 subtypes. The chapter describes a large number of fibroblastic/myofibroblastic tumor entities. Alveolar rhabdomyosarcomas (ARMS) and embryonal rhabdomyosarcomas (ERMS) show largely similar patterns of genomic imbalances, although most of them occur at higher frequencies among the latter. The chromosome numbers of 70 undifferentiated pleomorphic sarcomas varied from near haploidy to hyperoctaploidy. Cytogenetic analyses have revealed that practically all soft tissue tumor types harbor acquired chromosome aberrations. The type of aberrations and the level of karyotypic complexity vary considerably from one tumor entity to another. At one end are the pathognomonic translocations that by themselves are extremely useful diagnostic signatures. Detection of such aberrations, by cytogenetic or molecular genetic means, is useful in the diagnostic setting when combined with clinicopathologic data. The prognostic impact of the genetic aberrations identified in soft tissue tumors is largely unknown.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Alveolar rhabdomyosarcomas, Chromosome aberrations, Embryonal rhabdomyosarcomas, Pathognomonic translocations, Pleomorphic sarcomas, Soft tissue tumors
in
Cancer Cytogenetics
editor
Heim, Sverre; Mitelman, Felix; and
pages
32 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85015969604
ISBN
9781118795569
9781118795538
DOI
10.1002/9781118795569.ch24
language
English
LU publication?
yes
id
d13fac25-583d-4117-a862-b27b2ea5caae
date added to LUP
2017-04-20 10:26:37
date last changed
2017-09-24 05:09:54
@inbook{d13fac25-583d-4117-a862-b27b2ea5caae,
  abstract     = {<p>Soft tissue tumors are highly heterogeneous with more than 100 subtypes. The chapter describes a large number of fibroblastic/myofibroblastic tumor entities. Alveolar rhabdomyosarcomas (ARMS) and embryonal rhabdomyosarcomas (ERMS) show largely similar patterns of genomic imbalances, although most of them occur at higher frequencies among the latter. The chromosome numbers of 70 undifferentiated pleomorphic sarcomas varied from near haploidy to hyperoctaploidy. Cytogenetic analyses have revealed that practically all soft tissue tumor types harbor acquired chromosome aberrations. The type of aberrations and the level of karyotypic complexity vary considerably from one tumor entity to another. At one end are the pathognomonic translocations that by themselves are extremely useful diagnostic signatures. Detection of such aberrations, by cytogenetic or molecular genetic means, is useful in the diagnostic setting when combined with clinicopathologic data. The prognostic impact of the genetic aberrations identified in soft tissue tumors is largely unknown.</p>},
  author       = {Mandahl, Nils and Mertens, Fredrik},
  editor       = {Heim, Sverre and Mitelman, Felix},
  isbn         = {9781118795569},
  keyword      = {Alveolar rhabdomyosarcomas,Chromosome aberrations,Embryonal rhabdomyosarcomas,Pathognomonic translocations,Pleomorphic sarcomas,Soft tissue tumors},
  language     = {eng},
  pages        = {583--614},
  publisher    = {Wiley-Blackwell},
  series       = {Cancer Cytogenetics},
  title        = {Soft tissue tumors},
  url          = {http://dx.doi.org/10.1002/9781118795569.ch24},
  year         = {2015},
}