Soft tissue tumors
(2015) p.583-614- Abstract
Soft tissue tumors are highly heterogeneous with more than 100 subtypes. The chapter describes a large number of fibroblastic/myofibroblastic tumor entities. Alveolar rhabdomyosarcomas (ARMS) and embryonal rhabdomyosarcomas (ERMS) show largely similar patterns of genomic imbalances, although most of them occur at higher frequencies among the latter. The chromosome numbers of 70 undifferentiated pleomorphic sarcomas varied from near haploidy to hyperoctaploidy. Cytogenetic analyses have revealed that practically all soft tissue tumor types harbor acquired chromosome aberrations. The type of aberrations and the level of karyotypic complexity vary considerably from one tumor entity to another. At one end are the pathognomonic... (More)
Soft tissue tumors are highly heterogeneous with more than 100 subtypes. The chapter describes a large number of fibroblastic/myofibroblastic tumor entities. Alveolar rhabdomyosarcomas (ARMS) and embryonal rhabdomyosarcomas (ERMS) show largely similar patterns of genomic imbalances, although most of them occur at higher frequencies among the latter. The chromosome numbers of 70 undifferentiated pleomorphic sarcomas varied from near haploidy to hyperoctaploidy. Cytogenetic analyses have revealed that practically all soft tissue tumor types harbor acquired chromosome aberrations. The type of aberrations and the level of karyotypic complexity vary considerably from one tumor entity to another. At one end are the pathognomonic translocations that by themselves are extremely useful diagnostic signatures. Detection of such aberrations, by cytogenetic or molecular genetic means, is useful in the diagnostic setting when combined with clinicopathologic data. The prognostic impact of the genetic aberrations identified in soft tissue tumors is largely unknown.
(Less)
- author
- Mandahl, Nils LU and Mertens, Fredrik LU
- organization
- publishing date
- 2015
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Alveolar rhabdomyosarcomas, Chromosome aberrations, Embryonal rhabdomyosarcomas, Pathognomonic translocations, Pleomorphic sarcomas, Soft tissue tumors
- host publication
- Cancer Cytogenetics : Chromosomal and Molecular Genetic Aberrations of Tumor Cells - Chromosomal and Molecular Genetic Aberrations of Tumor Cells
- editor
- Heim, Sverre and Mitelman, Felix
- edition
- 4th
- pages
- 32 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85015969604
- ISBN
- 9781118795538
- 9781118795569
- DOI
- 10.1002/9781118795569.ch24
- language
- English
- LU publication?
- yes
- id
- d13fac25-583d-4117-a862-b27b2ea5caae
- date added to LUP
- 2017-04-20 10:26:37
- date last changed
- 2024-01-28 16:35:31
@inbook{d13fac25-583d-4117-a862-b27b2ea5caae,
abstract = {{<p>Soft tissue tumors are highly heterogeneous with more than 100 subtypes. The chapter describes a large number of fibroblastic/myofibroblastic tumor entities. Alveolar rhabdomyosarcomas (ARMS) and embryonal rhabdomyosarcomas (ERMS) show largely similar patterns of genomic imbalances, although most of them occur at higher frequencies among the latter. The chromosome numbers of 70 undifferentiated pleomorphic sarcomas varied from near haploidy to hyperoctaploidy. Cytogenetic analyses have revealed that practically all soft tissue tumor types harbor acquired chromosome aberrations. The type of aberrations and the level of karyotypic complexity vary considerably from one tumor entity to another. At one end are the pathognomonic translocations that by themselves are extremely useful diagnostic signatures. Detection of such aberrations, by cytogenetic or molecular genetic means, is useful in the diagnostic setting when combined with clinicopathologic data. The prognostic impact of the genetic aberrations identified in soft tissue tumors is largely unknown.</p>}},
author = {{Mandahl, Nils and Mertens, Fredrik}},
booktitle = {{Cancer Cytogenetics : Chromosomal and Molecular Genetic Aberrations of Tumor Cells}},
editor = {{Heim, Sverre and Mitelman, Felix}},
isbn = {{9781118795538}},
keywords = {{Alveolar rhabdomyosarcomas; Chromosome aberrations; Embryonal rhabdomyosarcomas; Pathognomonic translocations; Pleomorphic sarcomas; Soft tissue tumors}},
language = {{eng}},
pages = {{583--614}},
publisher = {{Wiley-Blackwell}},
title = {{Soft tissue tumors}},
url = {{http://dx.doi.org/10.1002/9781118795569.ch24}},
doi = {{10.1002/9781118795569.ch24}},
year = {{2015}},
}