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Low 25-OH Vitamin D is Associated with Benign Prostatic Hyperplasia

Haghsheno, Mohammad-Ali ; Mellstrom, Dan ; Behre, Carl-Johan ; Damber, Jan-Erik ; Johansson, Helena ; Karlsson, Magnus LU ; Lorentzon, Mattias ; Peeker, Ralph ; Barret-Connor, Elisabet and Waern, Ewa , et al. (2013) In Journal of Urology 190(2). p.608-614
Abstract
Purpose: We tested the hypothesis that low vitamin D is associated with benign prostatic hyperplasia. We also studied whether body composition, sex hormones, serum sex hormone-binding globulin, albumin corrected serum calcium, adiponectin and lipid status are associated with benign prostatic hyperplasia. Materials and Methods: We investigated 184 representative, randomly selected men 72 to 76 years old enrolled in the Gothenburg arm of the Osteoporotic Fractures in Men Study (MrOS). Men with a history of prostate cancer, prostate operation or medication for benign prostatic hyperplasia were excluded from study, leaving 155 available for analysis. A cross-sectional study was performed in which benign prostatic hyperplasia measured by total... (More)
Purpose: We tested the hypothesis that low vitamin D is associated with benign prostatic hyperplasia. We also studied whether body composition, sex hormones, serum sex hormone-binding globulin, albumin corrected serum calcium, adiponectin and lipid status are associated with benign prostatic hyperplasia. Materials and Methods: We investigated 184 representative, randomly selected men 72 to 76 years old enrolled in the Gothenburg arm of the Osteoporotic Fractures in Men Study (MrOS). Men with a history of prostate cancer, prostate operation or medication for benign prostatic hyperplasia were excluded from study, leaving 155 available for analysis. A cross-sectional study was performed in which benign prostatic hyperplasia measured by total prostate volume was related to clinical, anthropometric, endocrine and metabolic factors on univariate and multivariate analyses with regression models. Results: Median prostate volume was 40 ml. In multivariate models only 25-OH vitamin D, albumin corrected serum calcium, serum sex hormone-binding globulin and high density lipoprotein cholesterol were significantly and inversely associated with large prostate glands. Conclusions: The current report adds 4 independent factors associated with benign prostatic hyperplasia, including low 25-OH vitamin D, serum calcium, sex hormone-binding globulin and high density lipoprotein cholesterol. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prostate, prostatic hyperplasia, sex hormone-binding globulin, lipoproteins, HDL, vitamin D
in
Journal of Urology
volume
190
issue
2
pages
608 - 614
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000321436600072
  • scopus:84880045144
  • pmid:23399651
ISSN
1527-3792
DOI
10.1016/j.juro.2013.01.104
language
English
LU publication?
yes
id
d1607bc8-145c-467c-9d0b-df67965be463 (old id 3975554)
date added to LUP
2016-04-01 13:03:24
date last changed
2022-01-27 17:01:06
@article{d1607bc8-145c-467c-9d0b-df67965be463,
  abstract     = {{Purpose: We tested the hypothesis that low vitamin D is associated with benign prostatic hyperplasia. We also studied whether body composition, sex hormones, serum sex hormone-binding globulin, albumin corrected serum calcium, adiponectin and lipid status are associated with benign prostatic hyperplasia. Materials and Methods: We investigated 184 representative, randomly selected men 72 to 76 years old enrolled in the Gothenburg arm of the Osteoporotic Fractures in Men Study (MrOS). Men with a history of prostate cancer, prostate operation or medication for benign prostatic hyperplasia were excluded from study, leaving 155 available for analysis. A cross-sectional study was performed in which benign prostatic hyperplasia measured by total prostate volume was related to clinical, anthropometric, endocrine and metabolic factors on univariate and multivariate analyses with regression models. Results: Median prostate volume was 40 ml. In multivariate models only 25-OH vitamin D, albumin corrected serum calcium, serum sex hormone-binding globulin and high density lipoprotein cholesterol were significantly and inversely associated with large prostate glands. Conclusions: The current report adds 4 independent factors associated with benign prostatic hyperplasia, including low 25-OH vitamin D, serum calcium, sex hormone-binding globulin and high density lipoprotein cholesterol.}},
  author       = {{Haghsheno, Mohammad-Ali and Mellstrom, Dan and Behre, Carl-Johan and Damber, Jan-Erik and Johansson, Helena and Karlsson, Magnus and Lorentzon, Mattias and Peeker, Ralph and Barret-Connor, Elisabet and Waern, Ewa and Sundh, Valter and Ohlsson, Claes and Hammarsten, Jan}},
  issn         = {{1527-3792}},
  keywords     = {{prostate; prostatic hyperplasia; sex hormone-binding globulin; lipoproteins; HDL; vitamin D}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{608--614}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Journal of Urology}},
  title        = {{Low 25-OH Vitamin D is Associated with Benign Prostatic Hyperplasia}},
  url          = {{http://dx.doi.org/10.1016/j.juro.2013.01.104}},
  doi          = {{10.1016/j.juro.2013.01.104}},
  volume       = {{190}},
  year         = {{2013}},
}