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Dynamics of proteins in solution

Grimaldo, Marco ; Roosen-Runge, Felix LU ; Zhang, Fajun ; Schreiber, Frank and Seydel, Tilo (2019) In Quarterly Reviews of Biophysics 52.
Abstract
The dynamics of proteins in solution includes a variety of processes, such as backbone and side-chain fluctuations, interdomain motions, as well as global rotational and translational (i.e. center of mass) diffusion. Since protein dynamics is related to protein function and essential transport processes, a detailed mechanistic understanding and monitoring of protein dynamics in solution is highly desirable. The hierarchical character of protein dynamics requires experimental tools addressing a broad range of time- and length scales. We discuss how different techniques contribute to a comprehensive picture of protein dynamics, and focus in particular on results from neutron spectroscopy. We outline the underlying principles and review... (More)
The dynamics of proteins in solution includes a variety of processes, such as backbone and side-chain fluctuations, interdomain motions, as well as global rotational and translational (i.e. center of mass) diffusion. Since protein dynamics is related to protein function and essential transport processes, a detailed mechanistic understanding and monitoring of protein dynamics in solution is highly desirable. The hierarchical character of protein dynamics requires experimental tools addressing a broad range of time- and length scales. We discuss how different techniques contribute to a comprehensive picture of protein dynamics, and focus in particular on results from neutron spectroscopy. We outline the underlying principles and review available instrumentation as well as related analysis frameworks. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Quarterly Reviews of Biophysics
volume
52
article number
e7
publisher
Cambridge University Press
ISSN
1469-8994
DOI
10.1017/S0033583519000027
language
English
LU publication?
yes
id
d1664dda-dba8-479e-b66c-52cf7afa4dd0
date added to LUP
2020-09-16 09:03:06
date last changed
2021-09-19 04:11:02
@article{d1664dda-dba8-479e-b66c-52cf7afa4dd0,
  abstract     = {{The dynamics of proteins in solution includes a variety of processes, such as backbone and side-chain fluctuations, interdomain motions, as well as global rotational and translational (i.e. center of mass) diffusion. Since protein dynamics is related to protein function and essential transport processes, a detailed mechanistic understanding and monitoring of protein dynamics in solution is highly desirable. The hierarchical character of protein dynamics requires experimental tools addressing a broad range of time- and length scales. We discuss how different techniques contribute to a comprehensive picture of protein dynamics, and focus in particular on results from neutron spectroscopy. We outline the underlying principles and review available instrumentation as well as related analysis frameworks.}},
  author       = {{Grimaldo, Marco and Roosen-Runge, Felix and Zhang, Fajun and Schreiber, Frank and Seydel, Tilo}},
  issn         = {{1469-8994}},
  language     = {{eng}},
  publisher    = {{Cambridge University Press}},
  series       = {{Quarterly Reviews of Biophysics}},
  title        = {{Dynamics of proteins in solution}},
  url          = {{http://dx.doi.org/10.1017/S0033583519000027}},
  doi          = {{10.1017/S0033583519000027}},
  volume       = {{52}},
  year         = {{2019}},
}