Will urbanisation affect the expression level of genes related to cancer of wild great tits?
Giraudeau, Mathieu ; Watson, Hannah LU ; Powell, Daniel LU ; Vincze, Orsolya ; Thomas, Frederic ; Sepp, Tuul ; Ujvari, Beata LU ; Le Loc'h, Guillaume and Isaksson, Caroline LU
(2020)
In Science of the Total Environment
714.
- Abstract
Recent studies suggest that oncogenic processes (from precancerous lesions to metastatic cancers) are widespread in wild animal species, but their importance for ecosystem functioning is still underestimated by evolutionary biologists and animal ecologists. Similar to what has been observed in humans, environmental modifications that often place wild organisms into an evolutionary trap and/or exposes them to a cocktail of mutagenic and carcinogenic pollutants might favor cancer emergence and progression, if animals do not up-regulate their defenses against these pathologies. Here, we compared, for the first time, the expression of 59 tumor-suppressor genes in blood and liver tissues of urban and rural great tits (Parus major); urban... (More)
Recent studies suggest that oncogenic processes (from precancerous lesions to metastatic cancers) are widespread in wild animal species, but their importance for ecosystem functioning is still underestimated by evolutionary biologists and animal ecologists. Similar to what has been observed in humans, environmental modifications that often place wild organisms into an evolutionary trap and/or exposes them to a cocktail of mutagenic and carcinogenic pollutants might favor cancer emergence and progression, if animals do not up-regulate their defenses against these pathologies. Here, we compared, for the first time, the expression of 59 tumor-suppressor genes in blood and liver tissues of urban and rural great tits (Parus major); urban conditions being known to favor cancer progression due to, among other things, exposure to chemical or light pollution. Contrary to earlier indications, once we aligned the transcriptome to the great tit genome, we found negligible differences in the expression of anti-cancer defenses between urban and rural birds in blood and liver. Our results indicate the higher expression of a single caretaker gene (i.e. BRCA1) in livers of rural compared to urban birds. We conclude that, while urban birds might be exposed to an environment favoring the development of oncogenic processes, they seem to not upregulate their cancer defenses accordingly and future studies should confirm this result by assessing more markers of cancer defenses. This may result in a mismatch that might predispose urban birds to higher cancer risk and future studies in urban ecology should take into account this, so far completely ignored, hazard.
(Less)
- author
- Giraudeau, Mathieu
; Watson, Hannah
LU
; Powell, Daniel
LU
; Vincze, Orsolya
; Thomas, Frederic
; Sepp, Tuul
; Ujvari, Beata
LU
; Le Loc'h, Guillaume
and Isaksson, Caroline
LU
- organization
- publishing date
- 2020-04-20
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cancer, Pollutants, Tumor-suppressor genes, Urbanization
- in
- Science of the Total Environment
- volume
- 714
- article number
- 135793
- publisher
- Elsevier
- external identifiers
-
- scopus:85078466790
- pmid:32018940
- ISSN
- 0048-9697
- DOI
- 10.1016/j.scitotenv.2019.135793
- language
- English
- LU publication?
- yes
- id
- d27235ba-e07a-4b7b-8b51-bdecd85ade33
- date added to LUP
- 2020-02-04 10:41:33
- date last changed
- 2024-05-02 03:51:40
@article{d27235ba-e07a-4b7b-8b51-bdecd85ade33,
abstract = {{<p>Recent studies suggest that oncogenic processes (from precancerous lesions to metastatic cancers) are widespread in wild animal species, but their importance for ecosystem functioning is still underestimated by evolutionary biologists and animal ecologists. Similar to what has been observed in humans, environmental modifications that often place wild organisms into an evolutionary trap and/or exposes them to a cocktail of mutagenic and carcinogenic pollutants might favor cancer emergence and progression, if animals do not up-regulate their defenses against these pathologies. Here, we compared, for the first time, the expression of 59 tumor-suppressor genes in blood and liver tissues of urban and rural great tits (Parus major); urban conditions being known to favor cancer progression due to, among other things, exposure to chemical or light pollution. Contrary to earlier indications, once we aligned the transcriptome to the great tit genome, we found negligible differences in the expression of anti-cancer defenses between urban and rural birds in blood and liver. Our results indicate the higher expression of a single caretaker gene (i.e. BRCA1) in livers of rural compared to urban birds. We conclude that, while urban birds might be exposed to an environment favoring the development of oncogenic processes, they seem to not upregulate their cancer defenses accordingly and future studies should confirm this result by assessing more markers of cancer defenses. This may result in a mismatch that might predispose urban birds to higher cancer risk and future studies in urban ecology should take into account this, so far completely ignored, hazard.</p>}},
author = {{Giraudeau, Mathieu and Watson, Hannah and Powell, Daniel and Vincze, Orsolya and Thomas, Frederic and Sepp, Tuul and Ujvari, Beata and Le Loc'h, Guillaume and Isaksson, Caroline}},
issn = {{0048-9697}},
keywords = {{Cancer; Pollutants; Tumor-suppressor genes; Urbanization}},
language = {{eng}},
month = {{04}},
publisher = {{Elsevier}},
series = {{Science of the Total Environment}},
title = {{Will urbanisation affect the expression level of genes related to cancer of wild great tits?}},
url = {{http://dx.doi.org/10.1016/j.scitotenv.2019.135793}},
doi = {{10.1016/j.scitotenv.2019.135793}},
volume = {{714}},
year = {{2020}},
}