Neocortical grafts placed in the infarcted brain of adult rats: few or no efferent fibers grow from transplant to host
(1995) In Experimental Neurology 134(2). p.273-276- Abstract
- The present study examines the capacity of fetal neocortical grafts placed in a brain infarct to exchange axonal projections with the host brain. Five to 7 days after a middle cerebral artery occlusion in adult spontaneously hypertensive rats, dissociated neocortical primordium from fetuses of gestational age 15-16 days was implanted into the infarcted area. Four to 11 months later, the neural tracers Phaseolus vulgaris-leucoagglutinin and Fluoro-Gold were injected in the grafts and host neocortex. An extensive axonal network was present in the transplants but only one of eight rats with appropriate placed injections displayed efferent connections from transplant to host. The sparse axonal outgrowth indicates major limitations for fetal... (More)
- The present study examines the capacity of fetal neocortical grafts placed in a brain infarct to exchange axonal projections with the host brain. Five to 7 days after a middle cerebral artery occlusion in adult spontaneously hypertensive rats, dissociated neocortical primordium from fetuses of gestational age 15-16 days was implanted into the infarcted area. Four to 11 months later, the neural tracers Phaseolus vulgaris-leucoagglutinin and Fluoro-Gold were injected in the grafts and host neocortex. An extensive axonal network was present in the transplants but only one of eight rats with appropriate placed injections displayed efferent connections from transplant to host. The sparse axonal outgrowth indicates major limitations for fetal rat cortical grafts to form connections with host neural circuitries after an ischemic insult. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109343
- author
- Grabowski, Martin LU ; Johansson, Barbro LU and Brundin, Patrik LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Experimental Neurology
- volume
- 134
- issue
- 2
- pages
- 273 - 276
- publisher
- Elsevier
- external identifiers
-
- pmid:7556547
- scopus:0028800456
- ISSN
- 0014-4886
- DOI
- 10.1006/exnr.1995.1057
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurology, Lund (013027000), Neuronal Survival (013212041)
- id
- d2970f75-8a1c-431c-b722-43b4b44c41fa (old id 1109343)
- date added to LUP
- 2016-04-01 12:12:40
- date last changed
- 2021-01-03 06:44:55
@article{d2970f75-8a1c-431c-b722-43b4b44c41fa,
abstract = {{The present study examines the capacity of fetal neocortical grafts placed in a brain infarct to exchange axonal projections with the host brain. Five to 7 days after a middle cerebral artery occlusion in adult spontaneously hypertensive rats, dissociated neocortical primordium from fetuses of gestational age 15-16 days was implanted into the infarcted area. Four to 11 months later, the neural tracers Phaseolus vulgaris-leucoagglutinin and Fluoro-Gold were injected in the grafts and host neocortex. An extensive axonal network was present in the transplants but only one of eight rats with appropriate placed injections displayed efferent connections from transplant to host. The sparse axonal outgrowth indicates major limitations for fetal rat cortical grafts to form connections with host neural circuitries after an ischemic insult.}},
author = {{Grabowski, Martin and Johansson, Barbro and Brundin, Patrik}},
issn = {{0014-4886}},
language = {{eng}},
number = {{2}},
pages = {{273--276}},
publisher = {{Elsevier}},
series = {{Experimental Neurology}},
title = {{Neocortical grafts placed in the infarcted brain of adult rats: few or no efferent fibers grow from transplant to host}},
url = {{http://dx.doi.org/10.1006/exnr.1995.1057}},
doi = {{10.1006/exnr.1995.1057}},
volume = {{134}},
year = {{1995}},
}