Environmental influence on recovery after brain lesions--experimental and clinical data.
(2003) In Journal of Rehabilitation Medicine 35(41 Suppl). p.41594-41594- Abstract
- One aim of rehabilitation after brain lesions should be to optimise the function of the remaining intact brain. Experimental studies on focal cerebral infarcts in the rat have demonstrated that postischemic environmental enrichment significantly improves functional outcome, increases dendrite branching and number of dendritic spines in the contralateral cortex, influences expression of many genes and modifies lesion-induced stem cell differentiation in the hippocampus. Furthermore, environmental factors can interact with specific interventions such as necrotic grafting and drug treatment, which underlines the importance of general stimulation and activation in rehabilitation after brain damage. Animal laboratories often provide an... (More)
- One aim of rehabilitation after brain lesions should be to optimise the function of the remaining intact brain. Experimental studies on focal cerebral infarcts in the rat have demonstrated that postischemic environmental enrichment significantly improves functional outcome, increases dendrite branching and number of dendritic spines in the contralateral cortex, influences expression of many genes and modifies lesion-induced stem cell differentiation in the hippocampus. Furthermore, environmental factors can interact with specific interventions such as necrotic grafting and drug treatment, which underlines the importance of general stimulation and activation in rehabilitation after brain damage. Animal laboratories often provide an environment with little stimulation. This should be taken into account when evaluating the clinical relevance of animal studies on long-term functional outcome after brain lesions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/115810
- author
- Johansson, Barbro LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- stem, cell differentiation, transplantation, functional outcome, plasticity, brain infarcts, dendritic spines
- in
- Journal of Rehabilitation Medicine
- volume
- 35
- issue
- 41 Suppl
- pages
- 41594 - 41594
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000183336300003
- ISSN
- 1651-2081
- DOI
- 10.1080/16501960310010089
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Laboratory for Experimental Brain Research (013041000), Neurology, Lund (013027000)
- id
- d341c187-81ee-45fc-812d-59194c9d0aec (old id 115810)
- alternative location
- http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12817651&dopt=Abstract
- date added to LUP
- 2016-04-01 15:28:47
- date last changed
- 2022-01-28 05:32:38
@article{d341c187-81ee-45fc-812d-59194c9d0aec,
abstract = {{One aim of rehabilitation after brain lesions should be to optimise the function of the remaining intact brain. Experimental studies on focal cerebral infarcts in the rat have demonstrated that postischemic environmental enrichment significantly improves functional outcome, increases dendrite branching and number of dendritic spines in the contralateral cortex, influences expression of many genes and modifies lesion-induced stem cell differentiation in the hippocampus. Furthermore, environmental factors can interact with specific interventions such as necrotic grafting and drug treatment, which underlines the importance of general stimulation and activation in rehabilitation after brain damage. Animal laboratories often provide an environment with little stimulation. This should be taken into account when evaluating the clinical relevance of animal studies on long-term functional outcome after brain lesions.}},
author = {{Johansson, Barbro}},
issn = {{1651-2081}},
keywords = {{stem; cell differentiation; transplantation; functional outcome; plasticity; brain infarcts; dendritic spines}},
language = {{eng}},
number = {{41 Suppl}},
pages = {{41594--41594}},
publisher = {{Taylor & Francis}},
series = {{Journal of Rehabilitation Medicine}},
title = {{Environmental influence on recovery after brain lesions--experimental and clinical data.}},
url = {{http://dx.doi.org/10.1080/16501960310010089}},
doi = {{10.1080/16501960310010089}},
volume = {{35}},
year = {{2003}},
}