Circulating Biomarkers in Lower Extremity Artery Disease
(2022) In European Cardiology Review 17.- Abstract
Lower extremity artery disease (LEAD), a chronic condition with disturbed lower extremity circulation due to narrowing of the arteries, is predominantly caused by atherosclerosis and is associated with the presence of cardiovascular risk factors and an increased risk of cardiovascular events. LEAD is prevalent among older individuals and predicted to rise with the ageing population. In progressive disease, the patient experiences symptoms of ischaemia when walking and, in advanced critical limb-threatening ischaemia, even at rest. However, LEAD is asymptomatic in most patients, delaying diagnosis and treatment. In this setting, circulating biomarkers may facilitate earlier diagnosis in selected individuals. This review provides a broad... (More)
Lower extremity artery disease (LEAD), a chronic condition with disturbed lower extremity circulation due to narrowing of the arteries, is predominantly caused by atherosclerosis and is associated with the presence of cardiovascular risk factors and an increased risk of cardiovascular events. LEAD is prevalent among older individuals and predicted to rise with the ageing population. In progressive disease, the patient experiences symptoms of ischaemia when walking and, in advanced critical limb-threatening ischaemia, even at rest. However, LEAD is asymptomatic in most patients, delaying diagnosis and treatment. In this setting, circulating biomarkers may facilitate earlier diagnosis in selected individuals. This review provides a broad overview of the circulating biomarkers investigated to date in relation to LEAD and discusses their usefulness in clinical practice.
(Less)
- author
- Ziegler, Louise ; Hedin, Ulf and Gottsäter, Anders LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- biomarkers, lower extremity artery disease, Peripheral artery disease
- in
- European Cardiology Review
- volume
- 17
- article number
- e09
- publisher
- Radcliffe Group Ltd.
- external identifiers
-
- scopus:85128842855
- ISSN
- 1758-3756
- DOI
- 10.15420/ECR.2021.58
- language
- English
- LU publication?
- yes
- id
- d36f1b10-c0dc-4f1a-bd29-b586e1195d9d
- date added to LUP
- 2022-06-30 12:19:29
- date last changed
- 2024-02-18 01:19:22
@article{d36f1b10-c0dc-4f1a-bd29-b586e1195d9d, abstract = {{<p>Lower extremity artery disease (LEAD), a chronic condition with disturbed lower extremity circulation due to narrowing of the arteries, is predominantly caused by atherosclerosis and is associated with the presence of cardiovascular risk factors and an increased risk of cardiovascular events. LEAD is prevalent among older individuals and predicted to rise with the ageing population. In progressive disease, the patient experiences symptoms of ischaemia when walking and, in advanced critical limb-threatening ischaemia, even at rest. However, LEAD is asymptomatic in most patients, delaying diagnosis and treatment. In this setting, circulating biomarkers may facilitate earlier diagnosis in selected individuals. This review provides a broad overview of the circulating biomarkers investigated to date in relation to LEAD and discusses their usefulness in clinical practice.</p>}}, author = {{Ziegler, Louise and Hedin, Ulf and Gottsäter, Anders}}, issn = {{1758-3756}}, keywords = {{biomarkers; lower extremity artery disease; Peripheral artery disease}}, language = {{eng}}, publisher = {{Radcliffe Group Ltd.}}, series = {{European Cardiology Review}}, title = {{Circulating Biomarkers in Lower Extremity Artery Disease}}, url = {{http://dx.doi.org/10.15420/ECR.2021.58}}, doi = {{10.15420/ECR.2021.58}}, volume = {{17}}, year = {{2022}}, }