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Circulating Biomarkers in Lower Extremity Artery Disease

Ziegler, Louise ; Hedin, Ulf and Gottsäter, Anders LU (2022) In European Cardiology Review 17.
Abstract

Lower extremity artery disease (LEAD), a chronic condition with disturbed lower extremity circulation due to narrowing of the arteries, is predominantly caused by atherosclerosis and is associated with the presence of cardiovascular risk factors and an increased risk of cardiovascular events. LEAD is prevalent among older individuals and predicted to rise with the ageing population. In progressive disease, the patient experiences symptoms of ischaemia when walking and, in advanced critical limb-threatening ischaemia, even at rest. However, LEAD is asymptomatic in most patients, delaying diagnosis and treatment. In this setting, circulating biomarkers may facilitate earlier diagnosis in selected individuals. This review provides a broad... (More)

Lower extremity artery disease (LEAD), a chronic condition with disturbed lower extremity circulation due to narrowing of the arteries, is predominantly caused by atherosclerosis and is associated with the presence of cardiovascular risk factors and an increased risk of cardiovascular events. LEAD is prevalent among older individuals and predicted to rise with the ageing population. In progressive disease, the patient experiences symptoms of ischaemia when walking and, in advanced critical limb-threatening ischaemia, even at rest. However, LEAD is asymptomatic in most patients, delaying diagnosis and treatment. In this setting, circulating biomarkers may facilitate earlier diagnosis in selected individuals. This review provides a broad overview of the circulating biomarkers investigated to date in relation to LEAD and discusses their usefulness in clinical practice.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biomarkers, lower extremity artery disease, Peripheral artery disease
in
European Cardiology Review
volume
17
article number
e09
publisher
Radcliffe Group Ltd.
external identifiers
  • scopus:85128842855
ISSN
1758-3756
DOI
10.15420/ECR.2021.58
language
English
LU publication?
yes
id
d36f1b10-c0dc-4f1a-bd29-b586e1195d9d
date added to LUP
2022-06-30 12:19:29
date last changed
2024-02-18 01:19:22
@article{d36f1b10-c0dc-4f1a-bd29-b586e1195d9d,
  abstract     = {{<p>Lower extremity artery disease (LEAD), a chronic condition with disturbed lower extremity circulation due to narrowing of the arteries, is predominantly caused by atherosclerosis and is associated with the presence of cardiovascular risk factors and an increased risk of cardiovascular events. LEAD is prevalent among older individuals and predicted to rise with the ageing population. In progressive disease, the patient experiences symptoms of ischaemia when walking and, in advanced critical limb-threatening ischaemia, even at rest. However, LEAD is asymptomatic in most patients, delaying diagnosis and treatment. In this setting, circulating biomarkers may facilitate earlier diagnosis in selected individuals. This review provides a broad overview of the circulating biomarkers investigated to date in relation to LEAD and discusses their usefulness in clinical practice.</p>}},
  author       = {{Ziegler, Louise and Hedin, Ulf and Gottsäter, Anders}},
  issn         = {{1758-3756}},
  keywords     = {{biomarkers; lower extremity artery disease; Peripheral artery disease}},
  language     = {{eng}},
  publisher    = {{Radcliffe Group Ltd.}},
  series       = {{European Cardiology Review}},
  title        = {{Circulating Biomarkers in Lower Extremity Artery Disease}},
  url          = {{http://dx.doi.org/10.15420/ECR.2021.58}},
  doi          = {{10.15420/ECR.2021.58}},
  volume       = {{17}},
  year         = {{2022}},
}