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Impact of Thyroid Autoimmunity on Thyroid Function in 12-year-old Children with Celiac Disease

Norström, Fredrik LU ; Van Der Pals, Maria LU ; Myléus, Anna ; Hammarroth, Solveig ; Högberg, Lotta ; Isaksson, Anders LU ; Ivarsson, Anneli and Carlsson, Annelie LU orcid (2018) In Journal of Pediatric Gastroenterology and Nutrition 67(1). p.64-68
Abstract

Objectives: Celiac disease (CD) is associated with thyroid autoimmunity and other autoimmune diseases. Data are, however, lacking regarding the relationship between thyroid autoimmunity and thyroid function, especially in regard to CD. Our aim was to investigate the impact of thyroid autoimmunity on thyroid function in 12-year-old children with CD compared to their healthy peers. Methods: A case-referent study was conducted as part of a CD screening of 12-year-olds. Our study included 335 children with CD and 1695 randomly selected referents. Thyroid autoimmunity was assessed with antibodies against thyroid peroxidase (TPOAb). Thyroid function was assessed with thyroid-stimulating hormone and free thyroxine. Results: TPOAb positivity... (More)

Objectives: Celiac disease (CD) is associated with thyroid autoimmunity and other autoimmune diseases. Data are, however, lacking regarding the relationship between thyroid autoimmunity and thyroid function, especially in regard to CD. Our aim was to investigate the impact of thyroid autoimmunity on thyroid function in 12-year-old children with CD compared to their healthy peers. Methods: A case-referent study was conducted as part of a CD screening of 12-year-olds. Our study included 335 children with CD and 1695 randomly selected referents. Thyroid autoimmunity was assessed with antibodies against thyroid peroxidase (TPOAb). Thyroid function was assessed with thyroid-stimulating hormone and free thyroxine. Results: TPOAb positivity significantly increased the risk of developing hypothyroidism in all children. The odds ratios (with 95% confidence intervals) were 5.3 (2.7-11) in healthy 12-year-olds, 10 (3.2-32) in screening-detected CD cases, 19 (2.6-135) in previously diagnosed CD cases, and 12 (4.4-32) in all CD cases together. Among children with TPOAb positivity, hypothyroidism was significantly more common (odds ratio 3.1; 95% CI 1.03-9.6) in children with CD (10/19) than in children without CD (12/46). Conclusions: The risk of thyroid dysfunction due to thyroid autoimmunity is larger for those with CD than their healthy peers. Our study indicates that a gluten-free diet does not reduce the risk of thyroid dysfunction. Further studies are required for improved understanding of the role of the gluten-free diet for the risk of autoimmune diseases in children with CD.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
autoimmune diseases, Exploring the Iceberg of Celiacs in Sweden study, population-based study, screening
in
Journal of Pediatric Gastroenterology and Nutrition
volume
67
issue
1
pages
5 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:29373441
  • scopus:85050082104
ISSN
0277-2116
DOI
10.1097/MPG.0000000000001903
language
English
LU publication?
yes
id
d4451e19-1e0d-40c3-a276-9c2413a7c759
date added to LUP
2018-08-02 09:25:37
date last changed
2025-04-15 20:51:08
@article{d4451e19-1e0d-40c3-a276-9c2413a7c759,
  abstract     = {{<p>Objectives: Celiac disease (CD) is associated with thyroid autoimmunity and other autoimmune diseases. Data are, however, lacking regarding the relationship between thyroid autoimmunity and thyroid function, especially in regard to CD. Our aim was to investigate the impact of thyroid autoimmunity on thyroid function in 12-year-old children with CD compared to their healthy peers. Methods: A case-referent study was conducted as part of a CD screening of 12-year-olds. Our study included 335 children with CD and 1695 randomly selected referents. Thyroid autoimmunity was assessed with antibodies against thyroid peroxidase (TPOAb). Thyroid function was assessed with thyroid-stimulating hormone and free thyroxine. Results: TPOAb positivity significantly increased the risk of developing hypothyroidism in all children. The odds ratios (with 95% confidence intervals) were 5.3 (2.7-11) in healthy 12-year-olds, 10 (3.2-32) in screening-detected CD cases, 19 (2.6-135) in previously diagnosed CD cases, and 12 (4.4-32) in all CD cases together. Among children with TPOAb positivity, hypothyroidism was significantly more common (odds ratio 3.1; 95% CI 1.03-9.6) in children with CD (10/19) than in children without CD (12/46). Conclusions: The risk of thyroid dysfunction due to thyroid autoimmunity is larger for those with CD than their healthy peers. Our study indicates that a gluten-free diet does not reduce the risk of thyroid dysfunction. Further studies are required for improved understanding of the role of the gluten-free diet for the risk of autoimmune diseases in children with CD.</p>}},
  author       = {{Norström, Fredrik and Van Der Pals, Maria and Myléus, Anna and Hammarroth, Solveig and Högberg, Lotta and Isaksson, Anders and Ivarsson, Anneli and Carlsson, Annelie}},
  issn         = {{0277-2116}},
  keywords     = {{autoimmune diseases; Exploring the Iceberg of Celiacs in Sweden study; population-based study; screening}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{1}},
  pages        = {{64--68}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Journal of Pediatric Gastroenterology and Nutrition}},
  title        = {{Impact of Thyroid Autoimmunity on Thyroid Function in 12-year-old Children with Celiac Disease}},
  url          = {{http://dx.doi.org/10.1097/MPG.0000000000001903}},
  doi          = {{10.1097/MPG.0000000000001903}},
  volume       = {{67}},
  year         = {{2018}},
}