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Tuning the protein phosphorylation by receptor type protein tyrosine phosphatase epsilon (PTPRE) in normal and cancer cells

Liang, Jinping; Shi, Jun; Wang, Na; Zhao, Hui and Sun, Jianmin LU (2019) In Journal of Cancer 10(1). p.105-111
Abstract

Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely related with receptor type protein tyrosine phosphatase alpha (PTPRA). PTPRE has been studied in osteoclast cells, nerve cells, hematopoietic cells, cancer cells and others, and it has different functions among various tissues. In this review, we summarized the current knowledge about the regulation of PTPRE on cellular signal transduction and its function under normal and pathological conditions.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cancer, PTPRE, Signaling, Tyrosine phosphatase
in
Journal of Cancer
volume
10
issue
1
pages
7 pages
publisher
Hindawi Publishing Corporation
external identifiers
  • scopus:85059513100
ISSN
2090-2905
DOI
10.7150/jca.27633
language
English
LU publication?
yes
id
d48bf806-ff9d-4896-b4c9-0262d807ce42
date added to LUP
2019-01-22 14:54:48
date last changed
2019-02-20 11:43:57
@article{d48bf806-ff9d-4896-b4c9-0262d807ce42,
  abstract     = {<p>Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely related with receptor type protein tyrosine phosphatase alpha (PTPRA). PTPRE has been studied in osteoclast cells, nerve cells, hematopoietic cells, cancer cells and others, and it has different functions among various tissues. In this review, we summarized the current knowledge about the regulation of PTPRE on cellular signal transduction and its function under normal and pathological conditions.</p>},
  author       = {Liang, Jinping and Shi, Jun and Wang, Na and Zhao, Hui and Sun, Jianmin},
  issn         = {2090-2905},
  keyword      = {Cancer,PTPRE,Signaling,Tyrosine phosphatase},
  language     = {eng},
  number       = {1},
  pages        = {105--111},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Journal of Cancer},
  title        = {Tuning the protein phosphorylation by receptor type protein tyrosine phosphatase epsilon (PTPRE) in normal and cancer cells},
  url          = {http://dx.doi.org/10.7150/jca.27633},
  volume       = {10},
  year         = {2019},
}