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Photoacoustic imaging of the spatial distribution of oxygen saturation in an ischemia-reperfusion model in humans

Merdasa, Aboma LU orcid ; Bunke, Josefine LU ; Naumovska, Magdalena LU ; Albinsson, John LU orcid ; Erlöv, Tobias LU ; Cinthio, Magnus LU orcid ; Reistad, Nina LU orcid ; Sheikh, Rafi LU orcid and Malmsjö, Malin LU orcid (2021) In Biomedical Optics Express 12(4). p.2484-2495
Abstract

Photoacoustic imaging (PAI) is a novel hybrid imaging technique that combines the advantages of optical and ultrasound imaging to produce hyperspectral images of the tissue. The feasibility of measuring oxygen saturation (sO2) with PAI has been demonstrated pre-clinically, but has limited use in humans under conditions of ischemia and reperfusion. As an important step towards making PAI clinically available, we present a study in which PAI was used to estimate the spatial distribution of sO2 in vivo during and after occlusion of the finger of eight healthy volunteers. The results were compared with a commercial oxygen saturation monitor based on diffuse reflectance spectroscopy. We here describe the capability of... (More)

Photoacoustic imaging (PAI) is a novel hybrid imaging technique that combines the advantages of optical and ultrasound imaging to produce hyperspectral images of the tissue. The feasibility of measuring oxygen saturation (sO2) with PAI has been demonstrated pre-clinically, but has limited use in humans under conditions of ischemia and reperfusion. As an important step towards making PAI clinically available, we present a study in which PAI was used to estimate the spatial distribution of sO2 in vivo during and after occlusion of the finger of eight healthy volunteers. The results were compared with a commercial oxygen saturation monitor based on diffuse reflectance spectroscopy. We here describe the capability of PAI to provide spatially resolved picture of the evolution of sO2 during ischemia following vascular occlusion of a finger, demonstrating the clinical viability of PAI as a non-invasive diagnostic tool for diseases indicated by impaired microvascularization.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomedical Optics Express
volume
12
issue
4
pages
2484 - 2495
publisher
Optical Society of America
external identifiers
  • pmid:33996242
  • scopus:85104863472
ISSN
2156-7085
DOI
10.1364/BOE.418397
language
English
LU publication?
yes
additional info
Funding Information: Funding. Swedish Government for Clinical Research (ALF); Skånes universitetssjukhus; Region Kronoberg; Skåne County Council’s Research and Development Foundation; Lund University Grant for Research Infrastructure; Swedish Cancer Foundation; Stiftelsen Kronprinsessan Margaretas Arbetsnämnd för Synskadade; Stiftelsen för Synskadade i f.d. Malmöhus län; Lund Laser Center; IngaBritt och Arne Lundbergs Forskningsstiftelse; Cronqvist Foundation; Sveriges Läkarförbund. Publisher Copyright: © 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
id
d4c54955-f01d-4e18-b40e-ab9685baf7cf
date added to LUP
2021-05-11 20:53:32
date last changed
2025-04-04 14:40:26
@article{d4c54955-f01d-4e18-b40e-ab9685baf7cf,
  abstract     = {{<p>Photoacoustic imaging (PAI) is a novel hybrid imaging technique that combines the advantages of optical and ultrasound imaging to produce hyperspectral images of the tissue. The feasibility of measuring oxygen saturation (sO<sub>2</sub>) with PAI has been demonstrated pre-clinically, but has limited use in humans under conditions of ischemia and reperfusion. As an important step towards making PAI clinically available, we present a study in which PAI was used to estimate the spatial distribution of sO<sub>2</sub> in vivo during and after occlusion of the finger of eight healthy volunteers. The results were compared with a commercial oxygen saturation monitor based on diffuse reflectance spectroscopy. We here describe the capability of PAI to provide spatially resolved picture of the evolution of sO<sub>2</sub> during ischemia following vascular occlusion of a finger, demonstrating the clinical viability of PAI as a non-invasive diagnostic tool for diseases indicated by impaired microvascularization.</p>}},
  author       = {{Merdasa, Aboma and Bunke, Josefine and Naumovska, Magdalena and Albinsson, John and Erlöv, Tobias and Cinthio, Magnus and Reistad, Nina and Sheikh, Rafi and Malmsjö, Malin}},
  issn         = {{2156-7085}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{2484--2495}},
  publisher    = {{Optical Society of America}},
  series       = {{Biomedical Optics Express}},
  title        = {{Photoacoustic imaging of the spatial distribution of oxygen saturation in an ischemia-reperfusion model in humans}},
  url          = {{http://dx.doi.org/10.1364/BOE.418397}},
  doi          = {{10.1364/BOE.418397}},
  volume       = {{12}},
  year         = {{2021}},
}