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13C imaging-a new diagnostic platform.

Månsson, Sven; Johansson, Edvin; Magnusson, Peter; Chai, Chun-Ming LU ; Hansson, Georg; Petersson, J Stefan; Ståhlberg, Freddy LU and Golman, Klaes (2006) In European Radiology 16(1). p.57-67
Abstract
he evolution of magnetic resonance imaging (MRI) has been astounding since the early 1980s, and a broad range of applications has emerged. To date, clinical imaging of nuclei other than protons has been precluded for reasons of sensitivity. However, with the recent development of hyperpolarization techniques, the signal from a given number of nuclei can be increased as much as 100,000 times, sufficient to enable imaging of nonproton nuclei. Technically, imaging of hyperpolarized nuclei offers several unique properties, such as complete lack of background signal and possibility for local and permanent destruction of the signal by means of radio frequency (RF) pulses. These properties allow for improved as well as new techniques within... (More)
he evolution of magnetic resonance imaging (MRI) has been astounding since the early 1980s, and a broad range of applications has emerged. To date, clinical imaging of nuclei other than protons has been precluded for reasons of sensitivity. However, with the recent development of hyperpolarization techniques, the signal from a given number of nuclei can be increased as much as 100,000 times, sufficient to enable imaging of nonproton nuclei. Technically, imaging of hyperpolarized nuclei offers several unique properties, such as complete lack of background signal and possibility for local and permanent destruction of the signal by means of radio frequency (RF) pulses. These properties allow for improved as well as new techniques within several application areas. Diagnostically, the injected compounds can visualize information about flow, perfusion, excretory function, and metabolic status. In this review article, we explain the concept of hyperpolarization and the techniques to hyperpolarize 13C. An overview of results obtained within angiography, perfusion, and catheter tracking is given, together with a discussion of the particular advantages and limitations. Finally, possible future directions of hyperpolarized 13C MRI are pointed out. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Magnetic resonance imaging (MRI), Hyperpolarized 13C, Metabolic imaging, New imaging applications
in
European Radiology
volume
16
issue
1
pages
57 - 67
publisher
Springer
external identifiers
  • wos:000234555100008
  • scopus:30844434180
ISSN
0938-7994
DOI
10.1007/s00330-005-2806-x
language
English
LU publication?
yes
id
d4dfac1f-1841-40c3-95e2-d17df25f017a (old id 140042)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15954020&dopt=Abstract
date added to LUP
2007-07-16 13:43:49
date last changed
2019-10-20 03:30:59
@article{d4dfac1f-1841-40c3-95e2-d17df25f017a,
  abstract     = {he evolution of magnetic resonance imaging (MRI) has been astounding since the early 1980s, and a broad range of applications has emerged. To date, clinical imaging of nuclei other than protons has been precluded for reasons of sensitivity. However, with the recent development of hyperpolarization techniques, the signal from a given number of nuclei can be increased as much as 100,000 times, sufficient to enable imaging of nonproton nuclei. Technically, imaging of hyperpolarized nuclei offers several unique properties, such as complete lack of background signal and possibility for local and permanent destruction of the signal by means of radio frequency (RF) pulses. These properties allow for improved as well as new techniques within several application areas. Diagnostically, the injected compounds can visualize information about flow, perfusion, excretory function, and metabolic status. In this review article, we explain the concept of hyperpolarization and the techniques to hyperpolarize 13C. An overview of results obtained within angiography, perfusion, and catheter tracking is given, together with a discussion of the particular advantages and limitations. Finally, possible future directions of hyperpolarized 13C MRI are pointed out.},
  author       = {Månsson, Sven and Johansson, Edvin and Magnusson, Peter and Chai, Chun-Ming and Hansson, Georg and Petersson, J Stefan and Ståhlberg, Freddy and Golman, Klaes},
  issn         = {0938-7994},
  keyword      = {Magnetic resonance imaging (MRI),Hyperpolarized 13C,Metabolic imaging,New imaging applications},
  language     = {eng},
  number       = {1},
  pages        = {57--67},
  publisher    = {Springer},
  series       = {European Radiology},
  title        = {13C imaging-a new diagnostic platform.},
  url          = {http://dx.doi.org/10.1007/s00330-005-2806-x},
  volume       = {16},
  year         = {2006},
}