GABA(A) receptor blockade inhibits Aβ fibre evoked wind-up in the arthritic rat
Weng, Han Rong ; Laird, Jennifer M.A. ; Cervero, Fernando and Schouenborg, Jens LU
(1998)
In NeuroReport
9(6).
p.1065-1069
- Abstract
To clarify the mechanisms of allodynia we have examined whether 'wind- up' of nociceptive withdrawal reflexes (NWR), a phenomenon characteristic of nociceptive C fiber spinal processing, can be mimicked by stimulation of tactile Aβ fibers in monoarthritic decerebrate spinal rats. Knee joint monoarthritis was induced by carrageenan/kaolin under halothane anaesthesia 5 h before recordings. In arthritic, but not in control rats, wind-up of NWR of the semitendinosus muscle could be evoked by repeated stimulation of Aβ fibres. By contrast, peroneus longus reflexes did not exhibit marked wind- up. Bicuculline (0.03-0.3 mg/kg, i.v.) dose-dependently inhibited this wind- up. Hence, reflex wind-up can be elicited by tactile Aβ fibers in... (More)
To clarify the mechanisms of allodynia we have examined whether 'wind- up' of nociceptive withdrawal reflexes (NWR), a phenomenon characteristic of nociceptive C fiber spinal processing, can be mimicked by stimulation of tactile Aβ fibers in monoarthritic decerebrate spinal rats. Knee joint monoarthritis was induced by carrageenan/kaolin under halothane anaesthesia 5 h before recordings. In arthritic, but not in control rats, wind-up of NWR of the semitendinosus muscle could be evoked by repeated stimulation of Aβ fibres. By contrast, peroneus longus reflexes did not exhibit marked wind- up. Bicuculline (0.03-0.3 mg/kg, i.v.) dose-dependently inhibited this wind- up. Hence, reflex wind-up can be elicited by tactile Aβ fibers in arthritic rats through a GABA(A) dependent mechanism.
(Less)
- author
- Weng, Han Rong
; Laird, Jennifer M.A.
; Cervero, Fernando
and Schouenborg, Jens
LU
- organization
- publishing date
- 1998-04-20
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Hyperalgesia, Presynaptic inhibition, Withdrawal reflexes
- in
- NeuroReport
- volume
- 9
- issue
- 6
- pages
- 5 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:9601668
- scopus:0032549865
- ISSN
- 0959-4965
- DOI
- 10.1097/00001756-199804200-00019
- language
- English
- LU publication?
- yes
- id
- d50140d4-3391-4790-8044-2a8cbd669a48
- date added to LUP
- 2019-06-25 16:02:34
- date last changed
- 2025-10-14 08:56:44
@article{d50140d4-3391-4790-8044-2a8cbd669a48,
abstract = {{<p>To clarify the mechanisms of allodynia we have examined whether 'wind- up' of nociceptive withdrawal reflexes (NWR), a phenomenon characteristic of nociceptive C fiber spinal processing, can be mimicked by stimulation of tactile Aβ fibers in monoarthritic decerebrate spinal rats. Knee joint monoarthritis was induced by carrageenan/kaolin under halothane anaesthesia 5 h before recordings. In arthritic, but not in control rats, wind-up of NWR of the semitendinosus muscle could be evoked by repeated stimulation of Aβ fibres. By contrast, peroneus longus reflexes did not exhibit marked wind- up. Bicuculline (0.03-0.3 mg/kg, i.v.) dose-dependently inhibited this wind- up. Hence, reflex wind-up can be elicited by tactile Aβ fibers in arthritic rats through a GABA(A) dependent mechanism.</p>}},
author = {{Weng, Han Rong and Laird, Jennifer M.A. and Cervero, Fernando and Schouenborg, Jens}},
issn = {{0959-4965}},
keywords = {{Hyperalgesia; Presynaptic inhibition; Withdrawal reflexes}},
language = {{eng}},
month = {{04}},
number = {{6}},
pages = {{1065--1069}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{NeuroReport}},
title = {{GABA(A) receptor blockade inhibits Aβ fibre evoked wind-up in the arthritic rat}},
url = {{http://dx.doi.org/10.1097/00001756-199804200-00019}},
doi = {{10.1097/00001756-199804200-00019}},
volume = {{9}},
year = {{1998}},
}