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Temporal relationship of sleep apnea and acromegaly : a nationwide study

Vouzouneraki, Konstantina; Franklin, Karl A.; Forsgren, Maria; Wärn, Maria; Persson, Jenny Tiberg; Wik, Helena; Dahlgren, Christina; Nilsson, Ann Sofie LU ; Alkebro, Caroline and Burman, Pia LU , et al. (2018) In Endocrine 62(2). p.456-463
Abstract

Purpose: Patients with acromegaly have an increased risk of sleep apnea, but reported prevalence rates vary largely. Here we aimed to evaluate the sleep apnea prevalence in a large national cohort of patients with acromegaly, to examine possible risk factors, and to assess the proportion of patients diagnosed with sleep apnea prior to acromegaly diagnosis. Methods: Cross-sectional multicenter study of 259 Swedish patients with acromegaly. At patients’ follow-up visits at the endocrine outpatient clinics of all seven university hospitals in Sweden, questionnaires were completed to assess previous sleep apnea diagnosis and treatment, cardiovascular diseases, smoking habits, anthropometric data, and S-IGF-1 levels. Daytime sleepiness was... (More)

Purpose: Patients with acromegaly have an increased risk of sleep apnea, but reported prevalence rates vary largely. Here we aimed to evaluate the sleep apnea prevalence in a large national cohort of patients with acromegaly, to examine possible risk factors, and to assess the proportion of patients diagnosed with sleep apnea prior to acromegaly diagnosis. Methods: Cross-sectional multicenter study of 259 Swedish patients with acromegaly. At patients’ follow-up visits at the endocrine outpatient clinics of all seven university hospitals in Sweden, questionnaires were completed to assess previous sleep apnea diagnosis and treatment, cardiovascular diseases, smoking habits, anthropometric data, and S-IGF-1 levels. Daytime sleepiness was evaluated using the Epworth Sleepiness Scale. Patients suspected to have undiagnosed sleep apnea were referred for sleep apnea investigations. Results: Of the 259 participants, 75 (29%) were diagnosed with sleep apnea before the study start. In 43 (57%) of these patients, sleep apnea had been diagnosed before the diagnosis of acromegaly. After clinical assessment and sleep studies, sleep apnea was diagnosed in an additional 20 patients, yielding a total sleep apnea prevalence of 37%. Higher sleep apnea risk was associated with higher BMI, waist circumference, and index finger circumference. Sleep apnea was more frequent among patients with S-IGF-1 levels in the highest quartile. Conclusion: Sleep apnea is common among patients with acromegaly, and is often diagnosed prior to their acromegaly diagnosis. These results support early screening for sleep apnea in patients with acromegaly and awareness for acromegaly in patients with sleep apnea.

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publication status
published
subject
keywords
Acromegaly, Comorbidities, Risk factors, Sleep apnea
in
Endocrine
volume
62
issue
2
pages
456 - 463
publisher
Humana Press
external identifiers
  • scopus:85052066042
ISSN
1355-008X
DOI
10.1007/s12020-018-1694-1
language
English
LU publication?
yes
id
d50a5fb1-e1f3-4b9e-a099-2c6bee1a7de7
date added to LUP
2018-10-05 10:01:07
date last changed
2019-03-19 04:00:15
@article{d50a5fb1-e1f3-4b9e-a099-2c6bee1a7de7,
  abstract     = {<p>Purpose: Patients with acromegaly have an increased risk of sleep apnea, but reported prevalence rates vary largely. Here we aimed to evaluate the sleep apnea prevalence in a large national cohort of patients with acromegaly, to examine possible risk factors, and to assess the proportion of patients diagnosed with sleep apnea prior to acromegaly diagnosis. Methods: Cross-sectional multicenter study of 259 Swedish patients with acromegaly. At patients’ follow-up visits at the endocrine outpatient clinics of all seven university hospitals in Sweden, questionnaires were completed to assess previous sleep apnea diagnosis and treatment, cardiovascular diseases, smoking habits, anthropometric data, and S-IGF-1 levels. Daytime sleepiness was evaluated using the Epworth Sleepiness Scale. Patients suspected to have undiagnosed sleep apnea were referred for sleep apnea investigations. Results: Of the 259 participants, 75 (29%) were diagnosed with sleep apnea before the study start. In 43 (57%) of these patients, sleep apnea had been diagnosed before the diagnosis of acromegaly. After clinical assessment and sleep studies, sleep apnea was diagnosed in an additional 20 patients, yielding a total sleep apnea prevalence of 37%. Higher sleep apnea risk was associated with higher BMI, waist circumference, and index finger circumference. Sleep apnea was more frequent among patients with S-IGF-1 levels in the highest quartile. Conclusion: Sleep apnea is common among patients with acromegaly, and is often diagnosed prior to their acromegaly diagnosis. These results support early screening for sleep apnea in patients with acromegaly and awareness for acromegaly in patients with sleep apnea.</p>},
  author       = {Vouzouneraki, Konstantina and Franklin, Karl A. and Forsgren, Maria and Wärn, Maria and Persson, Jenny Tiberg and Wik, Helena and Dahlgren, Christina and Nilsson, Ann Sofie and Alkebro, Caroline and Burman, Pia and Erfurth, Eva Marie and Wahlberg, Jeanette and Åkerman, Anna Karin and Høybye, Charlotte and Ragnarsson, Oskar and Engström, Britt Edén and Dahlqvist, Per},
  issn         = {1355-008X},
  keyword      = {Acromegaly,Comorbidities,Risk factors,Sleep apnea},
  language     = {eng},
  month        = {07},
  number       = {2},
  pages        = {456--463},
  publisher    = {Humana Press},
  series       = {Endocrine},
  title        = {Temporal relationship of sleep apnea and acromegaly : a nationwide study},
  url          = {http://dx.doi.org/10.1007/s12020-018-1694-1},
  volume       = {62},
  year         = {2018},
}