Orthostatic blood pressure reactions and resting heart rate in relation to lung function - the Swedish CArdioPulmonary bioImage Study (SCAPIS)
Casselbrant, Andreas LU ; Zambach, Christian LU
; Fedorowski, Artur
LU
; Engström, Gunnar
LU
; Wollmer, Per
LU
and Hamrefors, Viktor
LU
(2024)
In BMC Pulmonary Medicine
24.
- Abstract
BACKGROUND: There is a well-known comorbidity between chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) which is only partially explained by common risk factors. Markers of cardiovascular autonomic dysfunction (CVAD), such as orthostatic hypotension and increased resting heart rate, are strongly associated with CAD. The autonomic nervous system also innervates the airways, and several studies have shown an association between autonomic dysfunction and COPD. However, less is known about whether CVAD and impairment of respiratory capacity are related in the population. We thus aimed to assess the relationship between markers of subtle CVAD and lung function in middle-aged subjects.
METHODS: In this... (More)
BACKGROUND: There is a well-known comorbidity between chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) which is only partially explained by common risk factors. Markers of cardiovascular autonomic dysfunction (CVAD), such as orthostatic hypotension and increased resting heart rate, are strongly associated with CAD. The autonomic nervous system also innervates the airways, and several studies have shown an association between autonomic dysfunction and COPD. However, less is known about whether CVAD and impairment of respiratory capacity are related in the population. We thus aimed to assess the relationship between markers of subtle CVAD and lung function in middle-aged subjects.
METHODS: In this cross-sectional study, we analysed data from CVAD assessment (orthostatic blood pressure and heart rate measurements) and pulmonary function tests from 5886 individuals from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Subjects were middle aged and randomly selected from the Swedish population. Linear regression models and ANOVA analyses were used to relate orthostatic blood pressure and resting heart rate to lung function parameters (forced vital capacity (FVC), forced expiratory volume in one second (FEV
1), FEV
1/FVC-ratio, diffusion capacity for carbon monoxide (D
LCO), respiratory resistance at 5 Hz (R5), respiratory resistance at 20 Hz (R20), decrease in resistance from R5 to R20 (R5-R20), reactance in distal airways (X5), resonant frequency (Fres) and reactance area (AX)).
RESULTS: Increasing systolic orthostatic blood pressure, decreasing diastolic orthostatic blood pressure, and increased resting heart rate associated with lower FVC (all p < 0.001) and FEV
1 (p = 0.001; p = 0.005; p < 0.001, respectively) in models including age, sex and height. Apart from diastolic orthostatic blood pressure and FEV
1, all relationships remained significant after adjustment for possible confounders. Increased resting heart rate was associated with reduced D
LCO (p < 0.001).
CONCLUSIONS: Increasing systolic orthostatic blood pressure, decreasing diastolic orthostatic blood pressure, and increased resting heart rate are associated with lower lung function, after adjustments for age, sex and height. These finding indicates associations between signs of cardiovascular autonomic dysfunction and lower lung function in the general population. However, the observed differences in lung function were small and the clinical application is unclear.
(Less)
- author
- Casselbrant, Andreas
LU
; Zambach, Christian
LU
; Fedorowski, Artur
LU
; Engström, Gunnar
LU
; Wollmer, Per
LU
and Hamrefors, Viktor
LU
- organization
- publishing date
- 2024-11-28
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Male, Female, Middle Aged, Cross-Sectional Studies, Heart Rate/physiology, Sweden/epidemiology, Blood Pressure/physiology, Forced Expiratory Volume, Hypotension, Orthostatic/physiopathology, Lung/physiopathology, Respiratory Function Tests, Vital Capacity, Aged, Pulmonary Disease, Chronic Obstructive/physiopathology, Linear Models
- in
- BMC Pulmonary Medicine
- volume
- 24
- article number
- 587
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85211068394
- pmid:39604878
- ISSN
- 1471-2466
- DOI
- 10.1186/s12890-024-03398-8
- language
- English
- LU publication?
- yes
- additional info
- © 2024. The Author(s).
- id
- d526215b-6746-4191-889a-bcc92b4c7a06
- date added to LUP
- 2024-12-02 20:54:10
- date last changed
- 2025-05-14 21:58:37
@article{d526215b-6746-4191-889a-bcc92b4c7a06,
abstract = {{<p>BACKGROUND: There is a well-known comorbidity between chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) which is only partially explained by common risk factors. Markers of cardiovascular autonomic dysfunction (CVAD), such as orthostatic hypotension and increased resting heart rate, are strongly associated with CAD. The autonomic nervous system also innervates the airways, and several studies have shown an association between autonomic dysfunction and COPD. However, less is known about whether CVAD and impairment of respiratory capacity are related in the population. We thus aimed to assess the relationship between markers of subtle CVAD and lung function in middle-aged subjects.</p><p>METHODS: In this cross-sectional study, we analysed data from CVAD assessment (orthostatic blood pressure and heart rate measurements) and pulmonary function tests from 5886 individuals from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Subjects were middle aged and randomly selected from the Swedish population. Linear regression models and ANOVA analyses were used to relate orthostatic blood pressure and resting heart rate to lung function parameters (forced vital capacity (FVC), forced expiratory volume in one second (FEV<br>
1), FEV<br>
1/FVC-ratio, diffusion capacity for carbon monoxide (D<br>
LCO), respiratory resistance at 5 Hz (R5), respiratory resistance at 20 Hz (R20), decrease in resistance from R5 to R20 (R5-R20), reactance in distal airways (X5), resonant frequency (Fres) and reactance area (AX)).<br>
</p><p>RESULTS: Increasing systolic orthostatic blood pressure, decreasing diastolic orthostatic blood pressure, and increased resting heart rate associated with lower FVC (all p < 0.001) and FEV<br>
1 (p = 0.001; p = 0.005; p < 0.001, respectively) in models including age, sex and height. Apart from diastolic orthostatic blood pressure and FEV<br>
1, all relationships remained significant after adjustment for possible confounders. Increased resting heart rate was associated with reduced D<br>
LCO (p < 0.001).<br>
</p><p>CONCLUSIONS: Increasing systolic orthostatic blood pressure, decreasing diastolic orthostatic blood pressure, and increased resting heart rate are associated with lower lung function, after adjustments for age, sex and height. These finding indicates associations between signs of cardiovascular autonomic dysfunction and lower lung function in the general population. However, the observed differences in lung function were small and the clinical application is unclear.</p>}},
author = {{Casselbrant, Andreas and Zambach, Christian and Fedorowski, Artur and Engström, Gunnar and Wollmer, Per and Hamrefors, Viktor}},
issn = {{1471-2466}},
keywords = {{Humans; Male; Female; Middle Aged; Cross-Sectional Studies; Heart Rate/physiology; Sweden/epidemiology; Blood Pressure/physiology; Forced Expiratory Volume; Hypotension, Orthostatic/physiopathology; Lung/physiopathology; Respiratory Function Tests; Vital Capacity; Aged; Pulmonary Disease, Chronic Obstructive/physiopathology; Linear Models}},
language = {{eng}},
month = {{11}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Pulmonary Medicine}},
title = {{Orthostatic blood pressure reactions and resting heart rate in relation to lung function - the Swedish CArdioPulmonary bioImage Study (SCAPIS)}},
url = {{http://dx.doi.org/10.1186/s12890-024-03398-8}},
doi = {{10.1186/s12890-024-03398-8}},
volume = {{24}},
year = {{2024}},
}