Chemerin Is an Antimicrobial Agent in Human Epidermis
(2013) In PLoS ONE 8(3).- Abstract
- Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent. Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val 66 -Pro 85, which causes direct bacterial lysis. Therefore, chemerin is an antimicrobial agent in human skin.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3854842
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 8
- issue
- 3
- article number
- e58709
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000317562600033
- scopus:84875191852
- pmid:23527010
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0058709
- language
- English
- LU publication?
- yes
- id
- d56b96d0-4acb-437e-b2ff-172fb7256e0f (old id 3854842)
- date added to LUP
- 2016-04-01 14:52:34
- date last changed
- 2022-04-06 20:57:03
@article{d56b96d0-4acb-437e-b2ff-172fb7256e0f, abstract = {{Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent. Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val 66 -Pro 85, which causes direct bacterial lysis. Therefore, chemerin is an antimicrobial agent in human skin.}}, author = {{Banas, Magdalena and Zabieglo, Katarzyna and Kasetty, Gopinath and Kapinska-Mrowiecka, Monika and Borowczyk, Julia and Drukala, Justyna and Murzyn, Krzysztof and Zabel, Brian A. and Butcher, Eugene C. and Schroeder, Jens M. and Schmidtchen, Artur and Cichy, Joanna}}, issn = {{1932-6203}}, language = {{eng}}, number = {{3}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Chemerin Is an Antimicrobial Agent in Human Epidermis}}, url = {{https://lup.lub.lu.se/search/files/4209779/4058008.pdf}}, doi = {{10.1371/journal.pone.0058709}}, volume = {{8}}, year = {{2013}}, }