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Chemerin Is an Antimicrobial Agent in Human Epidermis

Banas, Magdalena; Zabieglo, Katarzyna; Kasetty, Gopinath LU ; Kapinska-Mrowiecka, Monika; Borowczyk, Julia; Drukala, Justyna; Murzyn, Krzysztof; Zabel, Brian A.; Butcher, Eugene C. and Schroeder, Jens M., et al. (2013) In PLoS ONE 8(3).
Abstract
Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent. Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val 66 -Pro 85, which causes direct bacterial lysis. Therefore, chemerin is an antimicrobial agent in human skin.
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PLoS ONE
volume
8
issue
3
publisher
Public Library of Science
external identifiers
  • wos:000317562600033
  • scopus:84875191852
ISSN
1932-6203
DOI
10.1371/journal.pone.0058709
language
English
LU publication?
yes
id
d56b96d0-4acb-437e-b2ff-172fb7256e0f (old id 3854842)
date added to LUP
2013-07-01 07:04:20
date last changed
2019-10-23 03:36:54
@article{d56b96d0-4acb-437e-b2ff-172fb7256e0f,
  abstract     = {Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent. Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val 66 -Pro 85, which causes direct bacterial lysis. Therefore, chemerin is an antimicrobial agent in human skin.},
  articleno    = {e58709},
  author       = {Banas, Magdalena and Zabieglo, Katarzyna and Kasetty, Gopinath and Kapinska-Mrowiecka, Monika and Borowczyk, Julia and Drukala, Justyna and Murzyn, Krzysztof and Zabel, Brian A. and Butcher, Eugene C. and Schroeder, Jens M. and Schmidtchen, Artur and Cichy, Joanna},
  issn         = {1932-6203},
  language     = {eng},
  number       = {3},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Chemerin Is an Antimicrobial Agent in Human Epidermis},
  url          = {http://dx.doi.org/10.1371/journal.pone.0058709},
  volume       = {8},
  year         = {2013},
}