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High antibiotic susceptibility among bacterial pathogens in Swedish ICUs

Hanberger, Håkan ; Erlandsson, Marcus LU ; Burman, Lars G. ; Cars, Otto ; Gill, Hans ; Lindgren, Sune ; Nilsson, Lennart E. ; Olsson-Liljequist, Barbro and Walther, Sten (2004) In Scandinavian Journal of Infectious Diseases 36(1). p.24-30
Abstract

Local infection control measures, antibiotic consumption and patient demographics from 1999-2000 together with bacteriological analyses were investigated in 29 ICUs participating in the ICU-STRAMA programme. The median antibiotic consumption per ICU was 1147 (range 605-2143) daily doses per 1000 occupied bed d (DDD1000). Antibiotics to which >90% of isolates of an organism were susceptible were defined as treatment alternatives (TA90). The mean number of TA90 was low (1-2 per organism) for Enterococcus faecium (vancomycin:VAN), coagulase negative staphylococci (VAN), Pseudomonas aeruginosa (ceftazidime:CTZ, netilmicin: NET) and Stenotrophomonas maltophilia (CTZ, trimethoprim-sulfamethoxazole: TSU),... (More)

Local infection control measures, antibiotic consumption and patient demographics from 1999-2000 together with bacteriological analyses were investigated in 29 ICUs participating in the ICU-STRAMA programme. The median antibiotic consumption per ICU was 1147 (range 605-2143) daily doses per 1000 occupied bed d (DDD1000). Antibiotics to which >90% of isolates of an organism were susceptible were defined as treatment alternatives (TA90). The mean number of TA90 was low (1-2 per organism) for Enterococcus faecium (vancomycin:VAN), coagulase negative staphylococci (VAN), Pseudomonas aeruginosa (ceftazidime:CTZ, netilmicin: NET) and Stenotrophomonas maltophilia (CTZ, trimethoprim-sulfamethoxazole: TSU), but higher (3-7) for Acinetobacter spp. (imipenem:IMI, NET, TSU), Enterococcus faecalis (ampicillin:AMP, IMI, VAN), Serratia spp. (ciprofloxacin:CIP, IMI, NET), Enterobacter spp. (CIP, IMI, NET, TSU), E. coli (cefuroxime:CXM, cefotaxime/ceftazidime:CTX/CTZ, CIP, IMI, NET, piperacillin-tazobactam:PTZ, TSU), Klebsiella spp. (CTX/CTZ CIP, IMI, NET, PTZ, TSU) and Staphylococcus aureus (clindamycin, fusidic acid, NET, oxacillin, rifampicin, VAN). Of S. aureus isolates 2% were MRSA. Facilities for alcohol hand disinfection at each bed were available in 96% of the ICUs. The numbers of TA90 available were apparently higher than in ICUs in southern Europe and the US, despite a relatively high antibiotic consumption. This may be due to a moderate ecological impact of the used agents and the infection control routines in Swedish ICUs.

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author collaboration
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
36
issue
1
pages
24 - 30
publisher
Informa Healthcare
external identifiers
  • scopus:1242296972
  • pmid:15000555
ISSN
0036-5548
DOI
10.1080/00365540310017429
language
English
LU publication?
no
id
d56f54a8-849c-48c7-a641-2fa6babbe5c1
date added to LUP
2020-04-16 12:09:14
date last changed
2024-04-03 06:17:11
@article{d56f54a8-849c-48c7-a641-2fa6babbe5c1,
  abstract     = {{<p>Local infection control measures, antibiotic consumption and patient demographics from 1999-2000 together with bacteriological analyses were investigated in 29 ICUs participating in the ICU-STRAMA programme. The median antibiotic consumption per ICU was 1147 (range 605-2143) daily doses per 1000 occupied bed d (DDD<sub>1000</sub>). Antibiotics to which &gt;90% of isolates of an organism were susceptible were defined as treatment alternatives (TA<sub>90</sub>). The mean number of TA<sub>90</sub> was low (1-2 per organism) for Enterococcus faecium (vancomycin:VAN), coagulase negative staphylococci (VAN), Pseudomonas aeruginosa (ceftazidime:CTZ, netilmicin: NET) and Stenotrophomonas maltophilia (CTZ, trimethoprim-sulfamethoxazole: TSU), but higher (3-7) for Acinetobacter spp. (imipenem:IMI, NET, TSU), Enterococcus faecalis (ampicillin:AMP, IMI, VAN), Serratia spp. (ciprofloxacin:CIP, IMI, NET), Enterobacter spp. (CIP, IMI, NET, TSU), E. coli (cefuroxime:CXM, cefotaxime/ceftazidime:CTX/CTZ, CIP, IMI, NET, piperacillin-tazobactam:PTZ, TSU), Klebsiella spp. (CTX/CTZ CIP, IMI, NET, PTZ, TSU) and Staphylococcus aureus (clindamycin, fusidic acid, NET, oxacillin, rifampicin, VAN). Of S. aureus isolates 2% were MRSA. Facilities for alcohol hand disinfection at each bed were available in 96% of the ICUs. The numbers of TA<sub>90</sub> available were apparently higher than in ICUs in southern Europe and the US, despite a relatively high antibiotic consumption. This may be due to a moderate ecological impact of the used agents and the infection control routines in Swedish ICUs.</p>}},
  author       = {{Hanberger, Håkan and Erlandsson, Marcus and Burman, Lars G. and Cars, Otto and Gill, Hans and Lindgren, Sune and Nilsson, Lennart E. and Olsson-Liljequist, Barbro and Walther, Sten}},
  issn         = {{0036-5548}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{24--30}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Infectious Diseases}},
  title        = {{High antibiotic susceptibility among bacterial pathogens in Swedish ICUs}},
  url          = {{http://dx.doi.org/10.1080/00365540310017429}},
  doi          = {{10.1080/00365540310017429}},
  volume       = {{36}},
  year         = {{2004}},
}