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HbA1c levels and circulating inflammatory proteins at onset of type 1 diabetes in children and adolescents

Dereke, Jonatan LU orcid and Nilsson, Charlotta LU (2022) In Journal of Diabetes and Metabolic Disorders 21(2). p.1427-1432
Abstract

Purpose: Type 1 diabetes is an autoimmune disease that often develops during childhood. Complications such as retinopathy often occur during the course of the disease. Studies to identify possible predictors of complications in type 1 diabetes are needed; in particular markers able to identify risk of complications long before they occur. The first aim of this study was to investigate plasma levels of sCD163, sST2 and Gal-3 at diagnosis of type 1 diabetes in children and adolescents. The second aim was to study their correlation to HbA1c in this study cohort. Methods: Patients (n = 242, 0–18 years) with type 1 diabetes, at Helsingborg’s Hospital were included in this study and circulating levels of sCD163, sST2 and Gal-3 were... (More)

Purpose: Type 1 diabetes is an autoimmune disease that often develops during childhood. Complications such as retinopathy often occur during the course of the disease. Studies to identify possible predictors of complications in type 1 diabetes are needed; in particular markers able to identify risk of complications long before they occur. The first aim of this study was to investigate plasma levels of sCD163, sST2 and Gal-3 at diagnosis of type 1 diabetes in children and adolescents. The second aim was to study their correlation to HbA1c in this study cohort. Methods: Patients (n = 242, 0–18 years) with type 1 diabetes, at Helsingborg’s Hospital were included in this study and circulating levels of sCD163, sST2 and Gal-3 were investigated in plasma using commercially available DuoSet ELISA and supplementary ancillary kit. Results: Circulating sCD163 was significantly higher at diagnosis compared to after diagnosis (666 ± 318ng/ml and 505 ± 223ng/ml respectively; p < 0.001). Also sST2 was significantly higher (18.2 [12.7–25.6] ng/ml respectively 9.1 [6.3–13.5] ng/ml (p < 0.001), but Gal-3 levels did not differ from onset of diabetes to after diagnosis. HbA1c was shown to correlate to sCD163 (rs=0.36; p < 0.001), sST2 (rs=0.22; p = 0.016) and Gal-3 (rs=0.2; p = 0.020) in patients with a diabetes duration < 5 years. Conclusions: sCD163 levels increased in patients with recent-onset type 1 diabetes and the levels increased with higher HbA1c. Patients included in this study will be followed annually until the eventual development of diabetic complications, while continuously studying circulating levels of inflammatory proteins such as sCD163.

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Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Children, Complications, HbA1c, Inflammatory, Type 1 diabetes
in
Journal of Diabetes and Metabolic Disorders
volume
21
issue
2
pages
6 pages
publisher
BioMed Central (BMC)
external identifiers
  • pmid:36404844
  • scopus:85133621164
ISSN
2251-6581
DOI
10.1007/s40200-022-01075-3
language
English
LU publication?
yes
id
d58bd6de-fd78-4aed-8bec-a9fbb68459f2
date added to LUP
2022-08-30 17:04:58
date last changed
2024-11-01 09:14:48
@article{d58bd6de-fd78-4aed-8bec-a9fbb68459f2,
  abstract     = {{<p>Purpose: Type 1 diabetes is an autoimmune disease that often develops during childhood. Complications such as retinopathy often occur during the course of the disease. Studies to identify possible predictors of complications in type 1 diabetes are needed; in particular markers able to identify risk of complications long before they occur. The first aim of this study was to investigate plasma levels of sCD163, sST2 and Gal-3 at diagnosis of type 1 diabetes in children and adolescents. The second aim was to study their correlation to HbA1c in this study cohort. Methods: Patients (n = 242, 0–18 years) with type 1 diabetes, at Helsingborg’s Hospital were included in this study and circulating levels of sCD163, sST2 and Gal-3 were investigated in plasma using commercially available DuoSet ELISA and supplementary ancillary kit. Results: Circulating sCD163 was significantly higher at diagnosis compared to after diagnosis (666 ± 318ng/ml and 505 ± 223ng/ml respectively; p &lt; 0.001). Also sST2 was significantly higher (18.2 [12.7–25.6] ng/ml respectively 9.1 [6.3–13.5] ng/ml (p &lt; 0.001), but Gal-3 levels did not differ from onset of diabetes to after diagnosis. HbA1c was shown to correlate to sCD163 (r<sub>s</sub>=0.36; p &lt; 0.001), sST2 (r<sub>s</sub>=0.22; p = 0.016) and Gal-3 (r<sub>s</sub>=0.2; p = 0.020) in patients with a diabetes duration &lt; 5 years. Conclusions: sCD163 levels increased in patients with recent-onset type 1 diabetes and the levels increased with higher HbA1c. Patients included in this study will be followed annually until the eventual development of diabetic complications, while continuously studying circulating levels of inflammatory proteins such as sCD163.</p>}},
  author       = {{Dereke, Jonatan and Nilsson, Charlotta}},
  issn         = {{2251-6581}},
  keywords     = {{Children; Complications; HbA1c; Inflammatory; Type 1 diabetes}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{1427--1432}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Diabetes and Metabolic Disorders}},
  title        = {{HbA1c levels and circulating inflammatory proteins at onset of type 1 diabetes in children and adolescents}},
  url          = {{http://dx.doi.org/10.1007/s40200-022-01075-3}},
  doi          = {{10.1007/s40200-022-01075-3}},
  volume       = {{21}},
  year         = {{2022}},
}