Simultaneous Nonmotor Symptoms Do Not Affect General Validity but Interpretation of the Parkinson's Disease Motor Diary
Andersson, Hampus ; Bremer, Alexander ; Gandor, Florin ; Ebersbach, Georg ; Löhle, Matthias ; Odin, Per LU
and Storch, Alexander
(2025)
In Movement Disorders Clinical Practice
12(7).
p.979-984
- Abstract
Background: Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited. Objective: This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion). Methods: A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS. Results: Four hundred... (More)
Background: Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited. Objective: This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion). Methods: A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS. Results: Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states. Conclusions: Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.
(Less)
- author
- Andersson, Hampus
; Bremer, Alexander
; Gandor, Florin
; Ebersbach, Georg
; Löhle, Matthias
; Odin, Per
LU
and Storch, Alexander
- organization
- publishing date
- 2025-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- motor fluctuations, nonmotor symptoms, Parkinson's disease, PD home motor diary, validity
- in
- Movement Disorders Clinical Practice
- volume
- 12
- issue
- 7
- pages
- 6 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:105001678146
- pmid:40178037
- ISSN
- 2330-1619
- DOI
- 10.1002/mdc3.70061
- language
- English
- LU publication?
- yes
- id
- d5b18d21-2024-4a34-831a-a18e079f6edf
- date added to LUP
- 2025-09-04 10:26:31
- date last changed
- 2025-09-05 04:00:58
@article{d5b18d21-2024-4a34-831a-a18e079f6edf,
abstract = {{<p>Background: Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited. Objective: This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion). Methods: A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS. Results: Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states. Conclusions: Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.</p>}},
author = {{Andersson, Hampus and Bremer, Alexander and Gandor, Florin and Ebersbach, Georg and Löhle, Matthias and Odin, Per and Storch, Alexander}},
issn = {{2330-1619}},
keywords = {{motor fluctuations; nonmotor symptoms; Parkinson's disease; PD home motor diary; validity}},
language = {{eng}},
number = {{7}},
pages = {{979--984}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Movement Disorders Clinical Practice}},
title = {{Simultaneous Nonmotor Symptoms Do Not Affect General Validity but Interpretation of the Parkinson's Disease Motor Diary}},
url = {{http://dx.doi.org/10.1002/mdc3.70061}},
doi = {{10.1002/mdc3.70061}},
volume = {{12}},
year = {{2025}},
}