Cardiovascular risk factors regulate the expression of vascular endothelin receptors.
(2010) In Pharmacology and Therapeutics Jul 1. p.148-155- Abstract
- Cardiovascular disease remains as the leading cause of death in the developed world. However, there is limited knowledge about how cardiovascular risk factors actually cause vascular disease. Traditional cardiovascular risk factors include increased circulating levels of low-density lipoproteins, cigarette smoking and hypertension (both strongly related to arterial wall injury), inflammation and atherosclerosis. The vascular endothelin receptors are a protein family that belongs to the larger family of G-protein coupled receptors. They mediate vascular smooth muscle contraction, proliferation and apoptosis, which are important events in the pathogenesis of atherosclerotic vascular disease. Recent investigations into intracellular signaling... (More)
- Cardiovascular disease remains as the leading cause of death in the developed world. However, there is limited knowledge about how cardiovascular risk factors actually cause vascular disease. Traditional cardiovascular risk factors include increased circulating levels of low-density lipoproteins, cigarette smoking and hypertension (both strongly related to arterial wall injury), inflammation and atherosclerosis. The vascular endothelin receptors are a protein family that belongs to the larger family of G-protein coupled receptors. They mediate vascular smooth muscle contraction, proliferation and apoptosis, which are important events in the pathogenesis of atherosclerotic vascular disease. Recent investigations into intracellular signaling mechanisms suggest that the above risk factors increase the expression of endothelin receptors in vascular smooth muscle cells by activating intracellular mitogen-activated protein kinase pathways and downstream transcription factors such as nuclear factor-kappaB. Understanding the mechanisms involved in vascular endothelin receptor upregulation during cardiovascular disease may provide novel therapeutic approaches. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1626083
- author
- Xu, Cang-Bao LU ; Sun, Yang and Edvinsson, Lars LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pharmacology and Therapeutics
- volume
- Jul 1
- pages
- 148 - 155
- publisher
- Elsevier
- external identifiers
-
- wos:000280384900005
- pmid:20546781
- scopus:77954213061
- pmid:20546781
- ISSN
- 0163-7258
- DOI
- 10.1016/j.pharmthera.2010.04.013
- language
- English
- LU publication?
- yes
- id
- d5e23a79-e494-4e3e-8bc9-b84b67ea1fc1 (old id 1626083)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20546781?dopt=Abstract
- date added to LUP
- 2016-04-04 07:23:29
- date last changed
- 2024-01-12 01:19:22
@article{d5e23a79-e494-4e3e-8bc9-b84b67ea1fc1,
abstract = {{Cardiovascular disease remains as the leading cause of death in the developed world. However, there is limited knowledge about how cardiovascular risk factors actually cause vascular disease. Traditional cardiovascular risk factors include increased circulating levels of low-density lipoproteins, cigarette smoking and hypertension (both strongly related to arterial wall injury), inflammation and atherosclerosis. The vascular endothelin receptors are a protein family that belongs to the larger family of G-protein coupled receptors. They mediate vascular smooth muscle contraction, proliferation and apoptosis, which are important events in the pathogenesis of atherosclerotic vascular disease. Recent investigations into intracellular signaling mechanisms suggest that the above risk factors increase the expression of endothelin receptors in vascular smooth muscle cells by activating intracellular mitogen-activated protein kinase pathways and downstream transcription factors such as nuclear factor-kappaB. Understanding the mechanisms involved in vascular endothelin receptor upregulation during cardiovascular disease may provide novel therapeutic approaches.}},
author = {{Xu, Cang-Bao and Sun, Yang and Edvinsson, Lars}},
issn = {{0163-7258}},
language = {{eng}},
pages = {{148--155}},
publisher = {{Elsevier}},
series = {{Pharmacology and Therapeutics}},
title = {{Cardiovascular risk factors regulate the expression of vascular endothelin receptors.}},
url = {{https://lup.lub.lu.se/search/files/5137471/1637751.pdf}},
doi = {{10.1016/j.pharmthera.2010.04.013}},
volume = {{Jul 1}},
year = {{2010}},
}