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Reduced Toll-like receptor 4 expression in children with asymptomatic bacteriuria

Ragnarsdottir, Bryndis LU ; Samuelsson, Martin LU ; Gustafsson, Mattias LU ; Leijonhufvud, Irene LU ; Karpman, Diana LU and Svanborg, Catharina LU (2007) In Journal of Infectious Diseases 196(3). p.475-484
Abstract
Toll-like receptor (TLR) 4 is essential for the defense against infection with gram-negative pathogens, but reduced TLR4 expression has not been linked to altered disease susceptibility in humans. In mice, Tlr4 controls the mucosal response to Escherichia coli urinary tract infections. Inactivation of mouse Tlr4 causes an asymptomatic carrier state resembling asymptomatic bacteriuria (ABU). The present study compared neutrophil TLR4 expression levels between children with ABU (n = 17) and age-matched control subjects (n = 24), and significantly lower levels were detected in the patients with ABU. We also found elevated levels of the TLR4 adaptor protein TRIF and reduced levels of the TLR4-inhibitor SIGIRR in the patients with ABU, but... (More)
Toll-like receptor (TLR) 4 is essential for the defense against infection with gram-negative pathogens, but reduced TLR4 expression has not been linked to altered disease susceptibility in humans. In mice, Tlr4 controls the mucosal response to Escherichia coli urinary tract infections. Inactivation of mouse Tlr4 causes an asymptomatic carrier state resembling asymptomatic bacteriuria (ABU). The present study compared neutrophil TLR4 expression levels between children with ABU (n = 17) and age-matched control subjects (n = 24), and significantly lower levels were detected in the patients with ABU. We also found elevated levels of the TLR4 adaptor protein TRIF and reduced levels of the TLR4-inhibitor SIGIRR in the patients with ABU, but MyD88 and TRAM levels were not significantly altered. Altered TLR4 and adaptor protein expression might impair TLR4 signaling and explain the weak mucosal response to urinary tract infection in patients who develop ABU rather than symptomatic disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
196
issue
3
pages
475 - 484
publisher
Oxford University Press
external identifiers
  • wos:000247803300019
  • scopus:34247187130
ISSN
1537-6613
DOI
10.1086/518893
language
English
LU publication?
yes
id
d613d81c-3789-4055-8bd8-a5e730523ed2 (old id 646393)
date added to LUP
2007-12-14 09:47:06
date last changed
2017-10-01 04:51:45
@article{d613d81c-3789-4055-8bd8-a5e730523ed2,
  abstract     = {Toll-like receptor (TLR) 4 is essential for the defense against infection with gram-negative pathogens, but reduced TLR4 expression has not been linked to altered disease susceptibility in humans. In mice, Tlr4 controls the mucosal response to Escherichia coli urinary tract infections. Inactivation of mouse Tlr4 causes an asymptomatic carrier state resembling asymptomatic bacteriuria (ABU). The present study compared neutrophil TLR4 expression levels between children with ABU (n = 17) and age-matched control subjects (n = 24), and significantly lower levels were detected in the patients with ABU. We also found elevated levels of the TLR4 adaptor protein TRIF and reduced levels of the TLR4-inhibitor SIGIRR in the patients with ABU, but MyD88 and TRAM levels were not significantly altered. Altered TLR4 and adaptor protein expression might impair TLR4 signaling and explain the weak mucosal response to urinary tract infection in patients who develop ABU rather than symptomatic disease.},
  author       = {Ragnarsdottir, Bryndis and Samuelsson, Martin and Gustafsson, Mattias and Leijonhufvud, Irene and Karpman, Diana and Svanborg, Catharina},
  issn         = {1537-6613},
  language     = {eng},
  number       = {3},
  pages        = {475--484},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Reduced Toll-like receptor 4 expression in children with asymptomatic bacteriuria},
  url          = {http://dx.doi.org/10.1086/518893},
  volume       = {196},
  year         = {2007},
}