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Tetrahydroxystilbene glucoside-induced relaxation of the superior mesenteric artery via both endothelium-dependent and endothelium-independent mechanisms

Jia, Min ; Zhou, Xuan Xuan ; Qin, Qiaohong ; Wang, Fang ; Li, Jie ; Xu, Cang Bao LU and Wang, Siwang (2019) In Microvascular Research 123. p.42-49
Abstract

Tetrahydroxystilbene glucoside (TSG) is the main water-soluble component in Polygonum multiflorum Thunb, and it has many cardioprotective effects. Although TSG is able to relax blood vessels, its relaxation of rat superior mesenteric arteries and the underlying mechanism of this process are not clearly understood. The aim of the present study was to use in vivo and in vitro models to investigate the arterial relaxation effect of TSG on rat superior mesenteric arteries and the mechanisms involved. We found that TSG concentration-dependently relaxed the superior mesenteric artery with or without endothelium. The vasorelaxation induced by TSG is not related to the vasodilator derived factor NO but is rather by the inhibition of COX-2... (More)

Tetrahydroxystilbene glucoside (TSG) is the main water-soluble component in Polygonum multiflorum Thunb, and it has many cardioprotective effects. Although TSG is able to relax blood vessels, its relaxation of rat superior mesenteric arteries and the underlying mechanism of this process are not clearly understood. The aim of the present study was to use in vivo and in vitro models to investigate the arterial relaxation effect of TSG on rat superior mesenteric arteries and the mechanisms involved. We found that TSG concentration-dependently relaxed the superior mesenteric artery with or without endothelium. The vasorelaxation induced by TSG is not related to the vasodilator derived factor NO but is rather by the inhibition of COX-2 activity and decreased TXA2. We also found that the vasorelaxation induced by TSG was attenuated by 4‑AP. Moreover, TSG also inhibited the contraction induced by an increase in external calcium concentration in Ca2+-free medium plus KCl (60 mM). These results suggest that TSG induces relaxation in mesenteric arterial rings through an endothelium-dependent pathway that involves the inhibition of COX-2 activity and decreased in TXA2 and through an endothelium-independent pathway via opening of a voltage-dependent K+ channel, blockade of Ca2+ influx and release of intracellular Ca2+.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ca, COX-2/TXA, K, Microartery, Tetrahydroxystilbene glucoside
in
Microvascular Research
volume
123
pages
8 pages
publisher
Academic Press
external identifiers
  • pmid:30367840
  • scopus:85058946799
ISSN
0026-2862
DOI
10.1016/j.mvr.2018.10.007
language
English
LU publication?
yes
id
d650513b-8b2a-4541-aea8-497e13eae4de
date added to LUP
2019-01-02 10:55:41
date last changed
2024-02-14 14:20:20
@article{d650513b-8b2a-4541-aea8-497e13eae4de,
  abstract     = {{<p>Tetrahydroxystilbene glucoside (TSG) is the main water-soluble component in Polygonum multiflorum Thunb, and it has many cardioprotective effects. Although TSG is able to relax blood vessels, its relaxation of rat superior mesenteric arteries and the underlying mechanism of this process are not clearly understood. The aim of the present study was to use in vivo and in vitro models to investigate the arterial relaxation effect of TSG on rat superior mesenteric arteries and the mechanisms involved. We found that TSG concentration-dependently relaxed the superior mesenteric artery with or without endothelium. The vasorelaxation induced by TSG is not related to the vasodilator derived factor NO but is rather by the inhibition of COX-2 activity and decreased TXA<sub>2</sub>. We also found that the vasorelaxation induced by TSG was attenuated by 4‑AP. Moreover, TSG also inhibited the contraction induced by an increase in external calcium concentration in Ca<sup>2+</sup>-free medium plus KCl (60 mM). These results suggest that TSG induces relaxation in mesenteric arterial rings through an endothelium-dependent pathway that involves the inhibition of COX-2 activity and decreased in TXA<sub>2</sub> and through an endothelium-independent pathway via opening of a voltage-dependent K<sup>+</sup> channel, blockade of Ca<sup>2+</sup> influx and release of intracellular Ca<sup>2+</sup>.</p>}},
  author       = {{Jia, Min and Zhou, Xuan Xuan and Qin, Qiaohong and Wang, Fang and Li, Jie and Xu, Cang Bao and Wang, Siwang}},
  issn         = {{0026-2862}},
  keywords     = {{Ca; COX-2/TXA; K; Microartery; Tetrahydroxystilbene glucoside}},
  language     = {{eng}},
  month        = {{05}},
  pages        = {{42--49}},
  publisher    = {{Academic Press}},
  series       = {{Microvascular Research}},
  title        = {{Tetrahydroxystilbene glucoside-induced relaxation of the superior mesenteric artery via both endothelium-dependent and endothelium-independent mechanisms}},
  url          = {{http://dx.doi.org/10.1016/j.mvr.2018.10.007}},
  doi          = {{10.1016/j.mvr.2018.10.007}},
  volume       = {{123}},
  year         = {{2019}},
}