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Testing for thrombophilia in mesenteric venous thrombosis - Retrospective original study and systematic review

Zarrouk, M. LU ; Salim, S. LU ; Elf, J. LU ; Gottsäter, A. LU and Acosta, S. LU (2017) In Bailliere's Best Practice and Research in Clinical Gastroenterology 31(1). p.39-48
Abstract

The aim was to perform a local study of risk factors and thrombophilia in mesenteric venous thrombosis (MVT), and to review the literature concerning thrombophilia testing in MVT. Patients hospitalized for surgical or medical treatment of MVT at our center 2000-2015. A systematic review of observational studies was performed. In the local study, the most frequently identified risk factor was Factor V Leiden mutation. The systematic review included 14 original studies. The highest pooled percentage of any inherited thrombophilic factor were: Factor V Leiden mutation 9% (CI 2.9-16.1), prothrombin gene mutation 7% (CI 2.7-11.8). The highest pooled percentage of acquired thrombophilic factors were JAK2 V617F mutation 14% (CI -1.9-28.1). The... (More)

The aim was to perform a local study of risk factors and thrombophilia in mesenteric venous thrombosis (MVT), and to review the literature concerning thrombophilia testing in MVT. Patients hospitalized for surgical or medical treatment of MVT at our center 2000-2015. A systematic review of observational studies was performed. In the local study, the most frequently identified risk factor was Factor V Leiden mutation. The systematic review included 14 original studies. The highest pooled percentage of any inherited thrombophilic factor were: Factor V Leiden mutation 9% (CI 2.9-16.1), prothrombin gene mutation 7% (CI 2.7-11.8). The highest pooled percentage of acquired thrombophilic factors were JAK2 V617F mutation 14% (CI -1.9-28.1). The wide range of frequency of inherited and acquired thrombophilic factors in different populations indicates the necessity to relate these factors to background population based data in order to estimate their overrepresentation in MVT. There is a need to develop guidelines for when and how thrombophilia testing should be performed in MVT.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hypercoagulability, JAK2, Mesenteric venous thrombosis, Prothrombotic, Splanchnic vein thrombosis, Thrombophilia
in
Bailliere's Best Practice and Research in Clinical Gastroenterology
volume
31
issue
1
pages
39 - 48
publisher
Baillière Tindall
external identifiers
  • scopus:85009967881
  • wos:000400719800005
ISSN
1521-6918
DOI
10.1016/j.bpg.2016.11.002
language
English
LU publication?
yes
id
d6510890-d149-41fb-88d1-1d72210ead04
date added to LUP
2017-02-10 12:47:46
date last changed
2018-01-07 11:49:14
@article{d6510890-d149-41fb-88d1-1d72210ead04,
  abstract     = {<p>The aim was to perform a local study of risk factors and thrombophilia in mesenteric venous thrombosis (MVT), and to review the literature concerning thrombophilia testing in MVT. Patients hospitalized for surgical or medical treatment of MVT at our center 2000-2015. A systematic review of observational studies was performed. In the local study, the most frequently identified risk factor was Factor V Leiden mutation. The systematic review included 14 original studies. The highest pooled percentage of any inherited thrombophilic factor were: Factor V Leiden mutation 9% (CI 2.9-16.1), prothrombin gene mutation 7% (CI 2.7-11.8). The highest pooled percentage of acquired thrombophilic factors were JAK2 V617F mutation 14% (CI -1.9-28.1). The wide range of frequency of inherited and acquired thrombophilic factors in different populations indicates the necessity to relate these factors to background population based data in order to estimate their overrepresentation in MVT. There is a need to develop guidelines for when and how thrombophilia testing should be performed in MVT.</p>},
  author       = {Zarrouk, M. and Salim, S. and Elf, J. and Gottsäter, A. and Acosta, S.},
  issn         = {1521-6918},
  keyword      = {Hypercoagulability,JAK2,Mesenteric venous thrombosis,Prothrombotic,Splanchnic vein thrombosis,Thrombophilia},
  language     = {eng},
  number       = {1},
  pages        = {39--48},
  publisher    = {Baillière Tindall},
  series       = {Bailliere's Best Practice and Research in Clinical Gastroenterology},
  title        = {Testing for thrombophilia in mesenteric venous thrombosis - Retrospective original study and systematic review},
  url          = {http://dx.doi.org/10.1016/j.bpg.2016.11.002},
  volume       = {31},
  year         = {2017},
}