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Current smoking is associated with a larger waist circumference and a more androgenic profile in young healthy women from high-risk breast cancer families

Ellberg, Carolina LU ; Olsson, Håkan LU and Jernström, Helena LU (2018) In Cancer Causes and Control 29(2). p.243-251
Abstract

The purpose was to elucidate the interplay between current smoking, anthropometric measurements, and endogenous hormone levels in women ≤ 40 years. Questionnaires on lifestyle and reproductive factors were completed by 269 healthy women from high-risk breast cancer families between 1996 and 2006 in Sweden. Blood samples for analyses of plasma testosterone, estradiol, androstenedione, sex hormone-binding globulin, and body measurements were obtained 5–10 days before predicted onset of the next menstrual period. Women without smoking status, who were currently breastfeeding, or using hormonal contraception other than combined oral contraceptives (OCs) were excluded (n = 27). Current smokers (n = 57) had larger waist circumference... (More)

The purpose was to elucidate the interplay between current smoking, anthropometric measurements, and endogenous hormone levels in women ≤ 40 years. Questionnaires on lifestyle and reproductive factors were completed by 269 healthy women from high-risk breast cancer families between 1996 and 2006 in Sweden. Blood samples for analyses of plasma testosterone, estradiol, androstenedione, sex hormone-binding globulin, and body measurements were obtained 5–10 days before predicted onset of the next menstrual period. Women without smoking status, who were currently breastfeeding, or using hormonal contraception other than combined oral contraceptives (OCs) were excluded (n = 27). Current smokers (n = 57) had larger waist circumference (adjp = 0.004) and waist-to-hip ratio (WHR) (adjp = 0.007) than non-smokers (n = 185). In non-OC users, adjusted mean androstenedione levels were higher in current smokers compared with non-smokers (10.3 vs. 8.6 nmol/L; adjp = 0.0002). While in current OC users estradiol levels were higher in smokers compared with non-smokers (22.5 vs. 17.4 pg/mL; adjp = 0.012). In multivariable models, WHR was associated with both current smoking (adjp ≤ 0.016) and higher levels of androstenedione (adjp = 0.05) or bioavailable testosterone (adjp = 0.001). Among non-OC users, a more androgenic profile was observed in current smokers compared with non-smokers, but not in current OC users. Irrespective of OC use, current smoking was associated with increased waist circumference.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Androstenedione, Breast cancer, Oral contraceptives, Smoking, Testosterone, Waist-to-hip ratio
in
Cancer Causes and Control
volume
29
issue
2
pages
243 - 251
publisher
Springer
external identifiers
  • scopus:85039992043
ISSN
0957-5243
DOI
10.1007/s10552-017-0999-3
language
English
LU publication?
yes
id
d689ef8e-c0fc-488f-b1fb-e4d9ade6c542
date added to LUP
2018-01-23 14:44:33
date last changed
2018-02-20 14:25:46
@article{d689ef8e-c0fc-488f-b1fb-e4d9ade6c542,
  abstract     = {<p>The purpose was to elucidate the interplay between current smoking, anthropometric measurements, and endogenous hormone levels in women ≤ 40 years. Questionnaires on lifestyle and reproductive factors were completed by 269 healthy women from high-risk breast cancer families between 1996 and 2006 in Sweden. Blood samples for analyses of plasma testosterone, estradiol, androstenedione, sex hormone-binding globulin, and body measurements were obtained 5–10 days before predicted onset of the next menstrual period. Women without smoking status, who were currently breastfeeding, or using hormonal contraception other than combined oral contraceptives (OCs) were excluded (n = 27). Current smokers (n = 57) had larger waist circumference (<sub>adj</sub>p = 0.004) and waist-to-hip ratio (WHR) (<sub>adj</sub>p = 0.007) than non-smokers (n = 185). In non-OC users, adjusted mean androstenedione levels were higher in current smokers compared with non-smokers (10.3 vs. 8.6 nmol/L; <sub>adj</sub>p = 0.0002). While in current OC users estradiol levels were higher in smokers compared with non-smokers (22.5 vs. 17.4 pg/mL; <sub>adj</sub>p = 0.012). In multivariable models, WHR was associated with both current smoking (<sub>adj</sub>p ≤ 0.016) and higher levels of androstenedione (<sub>adj</sub>p = 0.05) or bioavailable testosterone (<sub>adj</sub>p = 0.001). Among non-OC users, a more androgenic profile was observed in current smokers compared with non-smokers, but not in current OC users. Irrespective of OC use, current smoking was associated with increased waist circumference.</p>},
  author       = {Ellberg, Carolina and Olsson, Håkan and Jernström, Helena},
  issn         = {0957-5243},
  keyword      = {Androstenedione,Breast cancer,Oral contraceptives,Smoking,Testosterone,Waist-to-hip ratio},
  language     = {eng},
  number       = {2},
  pages        = {243--251},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Current smoking is associated with a larger waist circumference and a more androgenic profile in young healthy women from high-risk breast cancer families},
  url          = {http://dx.doi.org/10.1007/s10552-017-0999-3},
  volume       = {29},
  year         = {2018},
}