Immunohistochemical and in situ hybridization studies of β- microseminoprotein in the human gastric mucosa
Weiber, H. LU ; Lindström, C. ; Lilja, H. LU
; Bjartell, A.
LU
and Fernlund, P.
LU
(1997)
In Histochemical Journal
29(11-12).
p.839-845
- Abstract
β-Microseminoprotein is a 10-kDa disulphide-rich protein with unknown function which is present in the mucus of the airways, gastrointestinal tract and urogenital tract. In this paper, an investigation of the distribution of β-microseminoprotein in the human stomach is reported. Immunohistochemistry and in situ hybridization were used. β-Microseminoprotein was found to be localized mainly in the antrum part of the stomach and in two types of cells. Cells of the most abundant type (designated M-cells) were the neutral mucin- containing cells in the bottom part of the gastric glands and the surface epithelium. Virtually all these cells contained both β-microseminoprotein mRNA and protein product. Cells of the second type (designated... (More)
β-Microseminoprotein is a 10-kDa disulphide-rich protein with unknown function which is present in the mucus of the airways, gastrointestinal tract and urogenital tract. In this paper, an investigation of the distribution of β-microseminoprotein in the human stomach is reported. Immunohistochemistry and in situ hybridization were used. β-Microseminoprotein was found to be localized mainly in the antrum part of the stomach and in two types of cells. Cells of the most abundant type (designated M-cells) were the neutral mucin- containing cells in the bottom part of the gastric glands and the surface epithelium. Virtually all these cells contained both β-microseminoprotein mRNA and protein product. Cells of the second type (designated E-cells) were found in a zone one-third up from the bottom of the gastric glands, where gastric endocrine cells are located. The E-cells were fewer than the M-cells and usually solitary. They seemed to have a high concentration of protein compared with their low mRNA level. The majority of the E-cells contained chromogranin A and gastrin. The observations made have implications for the understanding of the differentiation of the mucosal cells in the antrum of the stomach and form a basis for future studies of β-microseminoprotein in gastric disease.
(Less)
- author
- Weiber, H.
LU
; Lindström, C.
; Lilja, H.
LU
; Bjartell, A.
LU
and Fernlund, P.
LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Histochemical Journal
- volume
- 29
- issue
- 11-12
- pages
- 839 - 845
- publisher
- Springer
- external identifiers
-
- pmid:9466151
- scopus:0031413181
- ISSN
- 0018-2214
- DOI
- 10.1023/A:1026437706895
- language
- English
- LU publication?
- yes
- id
- d6e531f5-5ba7-4b20-b2de-78071ce1a387
- date added to LUP
- 2022-12-06 16:32:46
- date last changed
- 2024-01-03 19:31:33
@article{d6e531f5-5ba7-4b20-b2de-78071ce1a387,
abstract = {{<p>β-Microseminoprotein is a 10-kDa disulphide-rich protein with unknown function which is present in the mucus of the airways, gastrointestinal tract and urogenital tract. In this paper, an investigation of the distribution of β-microseminoprotein in the human stomach is reported. Immunohistochemistry and in situ hybridization were used. β-Microseminoprotein was found to be localized mainly in the antrum part of the stomach and in two types of cells. Cells of the most abundant type (designated M-cells) were the neutral mucin- containing cells in the bottom part of the gastric glands and the surface epithelium. Virtually all these cells contained both β-microseminoprotein mRNA and protein product. Cells of the second type (designated E-cells) were found in a zone one-third up from the bottom of the gastric glands, where gastric endocrine cells are located. The E-cells were fewer than the M-cells and usually solitary. They seemed to have a high concentration of protein compared with their low mRNA level. The majority of the E-cells contained chromogranin A and gastrin. The observations made have implications for the understanding of the differentiation of the mucosal cells in the antrum of the stomach and form a basis for future studies of β-microseminoprotein in gastric disease.</p>}},
author = {{Weiber, H. and Lindström, C. and Lilja, H. and Bjartell, A. and Fernlund, P.}},
issn = {{0018-2214}},
language = {{eng}},
number = {{11-12}},
pages = {{839--845}},
publisher = {{Springer}},
series = {{Histochemical Journal}},
title = {{Immunohistochemical and in situ hybridization studies of β- microseminoprotein in the human gastric mucosa}},
url = {{http://dx.doi.org/10.1023/A:1026437706895}},
doi = {{10.1023/A:1026437706895}},
volume = {{29}},
year = {{1997}},
}