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How bacteria hack the matrix and dodge the bullets of immunity

Paulsson, Magnus LU and Riesbeck, Kristian LU (2018) In European Respiratory Review 27(148).
Abstract

Haemophilus influenzae, Moraxella catarrhalis and Pseudomonas aeruginosa are common Gram-negative pathogens associated with an array of pulmonary diseases. All three species have multiple adhesins in their outer membrane, i.e. surface structures that confer the ability to bind to surrounding cells, proteins or tissues. This mini-review focuses on proteins with high affinity for the components of the extracellular matrix such as collagen, laminin, fibronectin and vitronectin. Adhesins are not structurally related and may be lipoproteins, transmembrane porins or large protruding trimeric auto-transporters. They enable bacteria to avoid being cleared together with mucus by attaching to patches of exposed extracellular matrix, or indirectly... (More)

Haemophilus influenzae, Moraxella catarrhalis and Pseudomonas aeruginosa are common Gram-negative pathogens associated with an array of pulmonary diseases. All three species have multiple adhesins in their outer membrane, i.e. surface structures that confer the ability to bind to surrounding cells, proteins or tissues. This mini-review focuses on proteins with high affinity for the components of the extracellular matrix such as collagen, laminin, fibronectin and vitronectin. Adhesins are not structurally related and may be lipoproteins, transmembrane porins or large protruding trimeric auto-transporters. They enable bacteria to avoid being cleared together with mucus by attaching to patches of exposed extracellular matrix, or indirectly adhering to epithelial cells using matrix proteins as bridging molecules. As more adhesins are being unravelled, it is apparent that bacterial adhesion is a highly conserved mechanism, and that most adhesins target the same regions on the proteins of the extracellular matrix. The surface exposed adhesins are prime targets for new vaccines and the interactions between proteins are often possible to inhibit with interfering molecules, e.g. heparin. In conclusion, this highly interesting research field of microbiology has unravelled host–pathogen interactions with high therapeutic potential.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Respiratory Review
volume
27
issue
148
publisher
European Respiratory Society
external identifiers
  • scopus:85050029207
ISSN
0905-9180
DOI
10.1183/16000617.0018-2018
language
English
LU publication?
yes
id
d6ff472c-51e0-4220-82f2-5ab53fc2e6a2
date added to LUP
2018-08-02 11:11:07
date last changed
2018-08-03 03:00:04
@article{d6ff472c-51e0-4220-82f2-5ab53fc2e6a2,
  abstract     = {<p>Haemophilus influenzae, Moraxella catarrhalis and Pseudomonas aeruginosa are common Gram-negative pathogens associated with an array of pulmonary diseases. All three species have multiple adhesins in their outer membrane, i.e. surface structures that confer the ability to bind to surrounding cells, proteins or tissues. This mini-review focuses on proteins with high affinity for the components of the extracellular matrix such as collagen, laminin, fibronectin and vitronectin. Adhesins are not structurally related and may be lipoproteins, transmembrane porins or large protruding trimeric auto-transporters. They enable bacteria to avoid being cleared together with mucus by attaching to patches of exposed extracellular matrix, or indirectly adhering to epithelial cells using matrix proteins as bridging molecules. As more adhesins are being unravelled, it is apparent that bacterial adhesion is a highly conserved mechanism, and that most adhesins target the same regions on the proteins of the extracellular matrix. The surface exposed adhesins are prime targets for new vaccines and the interactions between proteins are often possible to inhibit with interfering molecules, e.g. heparin. In conclusion, this highly interesting research field of microbiology has unravelled host–pathogen interactions with high therapeutic potential.</p>},
  articleno    = {180018},
  author       = {Paulsson, Magnus and Riesbeck, Kristian},
  issn         = {0905-9180},
  language     = {eng},
  number       = {148},
  publisher    = {European Respiratory Society},
  series       = {European Respiratory Review},
  title        = {How bacteria hack the matrix and dodge the bullets of immunity},
  url          = {http://dx.doi.org/10.1183/16000617.0018-2018},
  volume       = {27},
  year         = {2018},
}