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Occupational factors and risk of adult bone sarcomas: A multicentric case-control study in Europe

Merletti, F ; Richiardi, L ; Bertoni, F ; Ahrens, W ; Buemi, A ; Costa-Santos, C ; Eriksson, Mikael LU orcid ; Guenel, P ; Kaerlev, L and Jockel, KH , et al. (2006) In International Journal of Cancer 118(3). p.721-727
Abstract
We investigated the association between occupational factors and risk of bone sarcoma, a rare tumor with a largely unknown aetiology. A multicentric case-control study was conducted in 7 European countries in 1995-97. Ninety-six cases aged 35-69 years with a centrally reviewed diagnosis of bone sarcoma (68 chondrosarcomas and 28 osteosarcomas) were compared to 2,632 population (68%) or colon cancer (32%) controls. Subjects were interviewed to obtain information on occupational, medical and reproductive history, smoking and alcohol consumption and selected exposures including use of pesticides. Response proportions were 90% among cases and 66% among controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated for selected... (More)
We investigated the association between occupational factors and risk of bone sarcoma, a rare tumor with a largely unknown aetiology. A multicentric case-control study was conducted in 7 European countries in 1995-97. Ninety-six cases aged 35-69 years with a centrally reviewed diagnosis of bone sarcoma (68 chondrosarcomas and 28 osteosarcomas) were compared to 2,632 population (68%) or colon cancer (32%) controls. Subjects were interviewed to obtain information on occupational, medical and reproductive history, smoking and alcohol consumption and selected exposures including use of pesticides. Response proportions were 90% among cases and 66% among controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated for selected categories of job titles and branches of industry and for use of pesticides. We found an increased OR for bone sarcoma among blacksmiths, toolmakers, machine-tool operators (OR = 2.14, 95% CI 1.08-4.26), woodworkers (OR = 2.68, 95% CI 1.36-5.29) and construction workers (OR = 1.62, 95% CI 0.92-2.87). Ever users of pesticide had an OR of 2.33 (95% CI 1.31-4.13), with similar risks for exposure to insecticides and exposure to herbicides. Neither duration of employment in any of the analyzed occupational categories nor duration of use of pesticides showed an increasing trend in the risk of bone sarcoma. ORs of bone sarcoma were 1.03 (95% CI 0.23-4.57), 3.13 (95% CI 1.26-7.76) and 1.44 (95% CI 0.43-4.85) for the first, second and third fertile of days of use of pesticides. Our study suggests that novel and previously reported (woodworking) occupational factors play a role in the aetiology of bone sarcomas. (c) 2005 Wiley-Liss, Inc. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
multicentric case-control study, woodworkers, pesticides, adult bone sarcomas, occupational risk factors
in
International Journal of Cancer
volume
118
issue
3
pages
721 - 727
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:16108052
  • wos:000234443900027
  • scopus:30444434039
ISSN
0020-7136
DOI
10.1002/ijc.21388
language
English
LU publication?
yes
id
d713bf23-c40d-4c73-8350-696d5a10ba4c (old id 421528)
date added to LUP
2016-04-01 11:51:32
date last changed
2022-01-26 19:20:23
@article{d713bf23-c40d-4c73-8350-696d5a10ba4c,
  abstract     = {{We investigated the association between occupational factors and risk of bone sarcoma, a rare tumor with a largely unknown aetiology. A multicentric case-control study was conducted in 7 European countries in 1995-97. Ninety-six cases aged 35-69 years with a centrally reviewed diagnosis of bone sarcoma (68 chondrosarcomas and 28 osteosarcomas) were compared to 2,632 population (68%) or colon cancer (32%) controls. Subjects were interviewed to obtain information on occupational, medical and reproductive history, smoking and alcohol consumption and selected exposures including use of pesticides. Response proportions were 90% among cases and 66% among controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated for selected categories of job titles and branches of industry and for use of pesticides. We found an increased OR for bone sarcoma among blacksmiths, toolmakers, machine-tool operators (OR = 2.14, 95% CI 1.08-4.26), woodworkers (OR = 2.68, 95% CI 1.36-5.29) and construction workers (OR = 1.62, 95% CI 0.92-2.87). Ever users of pesticide had an OR of 2.33 (95% CI 1.31-4.13), with similar risks for exposure to insecticides and exposure to herbicides. Neither duration of employment in any of the analyzed occupational categories nor duration of use of pesticides showed an increasing trend in the risk of bone sarcoma. ORs of bone sarcoma were 1.03 (95% CI 0.23-4.57), 3.13 (95% CI 1.26-7.76) and 1.44 (95% CI 0.43-4.85) for the first, second and third fertile of days of use of pesticides. Our study suggests that novel and previously reported (woodworking) occupational factors play a role in the aetiology of bone sarcomas. (c) 2005 Wiley-Liss, Inc.}},
  author       = {{Merletti, F and Richiardi, L and Bertoni, F and Ahrens, W and Buemi, A and Costa-Santos, C and Eriksson, Mikael and Guenel, P and Kaerlev, L and Jockel, KH and Llopis-Gonzalez, A and Merler, E and Miranda, A and Morales-Suarez-Varela, MM and Olsson, Håkan and Fletcher, T and Olsen, J}},
  issn         = {{0020-7136}},
  keywords     = {{multicentric case-control study; woodworkers; pesticides; adult bone sarcomas; occupational risk factors}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{721--727}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Occupational factors and risk of adult bone sarcomas: A multicentric case-control study in Europe}},
  url          = {{http://dx.doi.org/10.1002/ijc.21388}},
  doi          = {{10.1002/ijc.21388}},
  volume       = {{118}},
  year         = {{2006}},
}