Modelling of the oxygen level response to feed rate perturbations in an industrial scale fermentation process
(2015) In Process Biochemistry 50(4). p.507-516- Abstract
- A study of the feasibility of perturbation-based control methods in industrial fed-batch fermentations based on experiments in industrial production scale bioreactors (>100 m(3)) is presented, as well as modelling of the relation between substrate feed rate and dissolved oxygen level in such a process. Several different types of perturbation-based control methods have been suggested for control of this type of process but it has been reported that perturbations in the feed rate may cause decreased productivity in fermentations. The results of this study show that perturbations in the feed rate of production scale fermentations can achieve significant dissolved oxygen level responses without decreased productivity. A model based on data... (More)
- A study of the feasibility of perturbation-based control methods in industrial fed-batch fermentations based on experiments in industrial production scale bioreactors (>100 m(3)) is presented, as well as modelling of the relation between substrate feed rate and dissolved oxygen level in such a process. Several different types of perturbation-based control methods have been suggested for control of this type of process but it has been reported that perturbations in the feed rate may cause decreased productivity in fermentations. The results of this study show that perturbations in the feed rate of production scale fermentations can achieve significant dissolved oxygen level responses without decreased productivity. A model based on data for dissolved oxygen responses and a simulation using a simple observer are given, showing that it is possible to model industrial mixing dynamics in a simple way and that this can be used for perturbation-based on-line estimation of the metabolic state of the system in regard to overflow metabolism. A frequency region where the model can be used has been identified, indicating which frequencies would be suitable for perturbation-based control in industrial fermentations. (C) 2015 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5401717
- author
- Johnsson, Ola LU ; Andersson, Jonas ; Lidén, Gunnar LU ; Johnsson, Charlotta LU and Hägglund, Tore LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Process modelling, Process control, Perturbation-based control, Industrial fermentation, Bacillus licheniformis
- in
- Process Biochemistry
- volume
- 50
- issue
- 4
- pages
- 507 - 516
- publisher
- Elsevier
- external identifiers
-
- wos:000353073100003
- scopus:84925588883
- ISSN
- 1873-3298
- DOI
- 10.1016/j.procbio.2015.01.009
- project
- PICLU
- language
- English
- LU publication?
- yes
- id
- d728b2aa-2836-44e2-947c-d80027b7e741 (old id 5401717)
- date added to LUP
- 2016-04-01 09:52:21
- date last changed
- 2023-11-23 18:45:49
@article{d728b2aa-2836-44e2-947c-d80027b7e741,
abstract = {{A study of the feasibility of perturbation-based control methods in industrial fed-batch fermentations based on experiments in industrial production scale bioreactors (>100 m(3)) is presented, as well as modelling of the relation between substrate feed rate and dissolved oxygen level in such a process. Several different types of perturbation-based control methods have been suggested for control of this type of process but it has been reported that perturbations in the feed rate may cause decreased productivity in fermentations. The results of this study show that perturbations in the feed rate of production scale fermentations can achieve significant dissolved oxygen level responses without decreased productivity. A model based on data for dissolved oxygen responses and a simulation using a simple observer are given, showing that it is possible to model industrial mixing dynamics in a simple way and that this can be used for perturbation-based on-line estimation of the metabolic state of the system in regard to overflow metabolism. A frequency region where the model can be used has been identified, indicating which frequencies would be suitable for perturbation-based control in industrial fermentations. (C) 2015 Elsevier Ltd. All rights reserved.}},
author = {{Johnsson, Ola and Andersson, Jonas and Lidén, Gunnar and Johnsson, Charlotta and Hägglund, Tore}},
issn = {{1873-3298}},
keywords = {{Process modelling; Process control; Perturbation-based control; Industrial fermentation; Bacillus licheniformis}},
language = {{eng}},
number = {{4}},
pages = {{507--516}},
publisher = {{Elsevier}},
series = {{Process Biochemistry}},
title = {{Modelling of the oxygen level response to feed rate perturbations in an industrial scale fermentation process}},
url = {{http://dx.doi.org/10.1016/j.procbio.2015.01.009}},
doi = {{10.1016/j.procbio.2015.01.009}},
volume = {{50}},
year = {{2015}},
}