Early and late invasive pneumococcal infection following stem cell transplantation: a European Bone Marrow Transplantation survey
(2002) In British Journal of Haematology 117(2). p.444-450- Abstract
- Streptococcus pneumoniae (S. pneumoniae) may cause severe and lethal infections months and years following stem cell transplantation (SCT). In a prospective survey over a 3.5-year period, we assessed the incidence, risk factors and outcome for invasive pneumococcal infection (IPI) following SCT. Fifty-one episodes of IPI were reported: 43 episodes after bone marrow transplantation (BMT) and 8 after peripheral blood stem cell transplantation (PBSCT); 35 after allogeneic SCT and 16 after autologous SCT. Seven IPI episodes, all bacteraemias, were defined as early, occurring 1-35 d (median 3 d) post transplantation. Forty-four episodes were defined as late (greater than or equal to 100 d post SCT), occurring 4 months to 10 years (median 17... (More)
- Streptococcus pneumoniae (S. pneumoniae) may cause severe and lethal infections months and years following stem cell transplantation (SCT). In a prospective survey over a 3.5-year period, we assessed the incidence, risk factors and outcome for invasive pneumococcal infection (IPI) following SCT. Fifty-one episodes of IPI were reported: 43 episodes after bone marrow transplantation (BMT) and 8 after peripheral blood stem cell transplantation (PBSCT); 35 after allogeneic SCT and 16 after autologous SCT. Seven IPI episodes, all bacteraemias, were defined as early, occurring 1-35 d (median 3 d) post transplantation. Forty-four episodes were defined as late (greater than or equal to 100 d post SCT), occurring 4 months to 10 years (median 17 months) post transplantation. The incidences of early and late IPI were 2.03/1000 and 8.63/1000 transplantations respectively (P = 0.001). A higher incidence of late IPI was observed after BMT than after PBSCT (10.99 versus 3.23/1000; P < 0.01) and after allogeneic versus autologous SCT (12.20 versus 4.60/1000; P < 0.01). There was a higher estimated incidence of IPI in allogeneic patients with than in those without graft-versus-host disease (GVHD) (18.85 versus 8.25/1000; P = 0.015). The mortality rate was 20%, including 2/7 of early and 8/44 of late IPI. S. pneumoniae is a rare but important complication during the aplastic phase after SCT. In conclusion, S. pneumoniae is a significant cause of morbidity late post-transplantation, especially in allogeneic patients, and particularly those with GVHD. The high IPI mortality rate, both early and late post-transplantation, requires preventive approaches, mainly effective immunization. (Less)
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https://lup.lub.lu.se/record/339671
- author
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- pneumonia, bacteraemia, Streptococcus pneumoniae, stem cell transplantation, graft-versus-host disease
- in
- British Journal of Haematology
- volume
- 117
- issue
- 2
- pages
- 444 - 450
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:11972532
- wos:000175251400028
- scopus:0036248164
- ISSN
- 0007-1048
- DOI
- 10.1046/j.1365-2141.2002.03457.x
- language
- English
- LU publication?
- yes
- id
- d7530d6d-e891-4c2e-bd8a-96b02327cad4 (old id 339671)
- date added to LUP
- 2016-04-01 11:56:21
- date last changed
- 2022-05-25 23:56:32
@article{d7530d6d-e891-4c2e-bd8a-96b02327cad4,
abstract = {{Streptococcus pneumoniae (S. pneumoniae) may cause severe and lethal infections months and years following stem cell transplantation (SCT). In a prospective survey over a 3.5-year period, we assessed the incidence, risk factors and outcome for invasive pneumococcal infection (IPI) following SCT. Fifty-one episodes of IPI were reported: 43 episodes after bone marrow transplantation (BMT) and 8 after peripheral blood stem cell transplantation (PBSCT); 35 after allogeneic SCT and 16 after autologous SCT. Seven IPI episodes, all bacteraemias, were defined as early, occurring 1-35 d (median 3 d) post transplantation. Forty-four episodes were defined as late (greater than or equal to 100 d post SCT), occurring 4 months to 10 years (median 17 months) post transplantation. The incidences of early and late IPI were 2.03/1000 and 8.63/1000 transplantations respectively (P = 0.001). A higher incidence of late IPI was observed after BMT than after PBSCT (10.99 versus 3.23/1000; P < 0.01) and after allogeneic versus autologous SCT (12.20 versus 4.60/1000; P < 0.01). There was a higher estimated incidence of IPI in allogeneic patients with than in those without graft-versus-host disease (GVHD) (18.85 versus 8.25/1000; P = 0.015). The mortality rate was 20%, including 2/7 of early and 8/44 of late IPI. S. pneumoniae is a rare but important complication during the aplastic phase after SCT. In conclusion, S. pneumoniae is a significant cause of morbidity late post-transplantation, especially in allogeneic patients, and particularly those with GVHD. The high IPI mortality rate, both early and late post-transplantation, requires preventive approaches, mainly effective immunization.}},
author = {{Engelhard, D and Cordonnier, C and Shaw, PJ and Parkalli, T and Guenther, C and Martino, R and Dekker, AW and Prentice, HG and Gustavsson, Anita and Nurnberger, W and Ljungman, P}},
issn = {{0007-1048}},
keywords = {{pneumonia; bacteraemia; Streptococcus pneumoniae; stem cell transplantation; graft-versus-host disease}},
language = {{eng}},
number = {{2}},
pages = {{444--450}},
publisher = {{Wiley-Blackwell}},
series = {{British Journal of Haematology}},
title = {{Early and late invasive pneumococcal infection following stem cell transplantation: a European Bone Marrow Transplantation survey}},
url = {{http://dx.doi.org/10.1046/j.1365-2141.2002.03457.x}},
doi = {{10.1046/j.1365-2141.2002.03457.x}},
volume = {{117}},
year = {{2002}},
}