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A novel mutation on the transferrin gene abolishes one N-glycosylation site and alters the pattern of transferrin isoforms, mimicking that observed after excessive alcohol consumption.

Grahn, Ammi ; Bengtson, Per LU ; Eklund, Erik and Asin-Cayuela, Jorge (2016) In Clinical Biochemistry 49(6). p.511-513
Abstract
In the process of obtaining a driver's license, a healthy 28year old man presented increased levels of disialo-transferrin (TF) (approx. 20%, ref. value<2) by HPLC analysis of TF isoforms (%CDT), while other markers of excessive alcohol consumption (PEth, MCV and γ-GT) were in the normal range. The objective of this study was to determine the cause of the increased %CDT levels.
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Biochemistry
volume
49
issue
6
pages
511 - 513
publisher
Elsevier
external identifiers
  • pmid:26656560
  • scopus:84951088635
  • wos:000373209700018
  • pmid:26656560
ISSN
1873-2933
DOI
10.1016/j.clinbiochem.2015.12.001
language
English
LU publication?
yes
id
d77e3881-9546-4419-9fb5-69ae32706542 (old id 8505155)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26656560?dopt=Abstract
date added to LUP
2016-04-04 08:16:25
date last changed
2022-01-29 03:16:01
@article{d77e3881-9546-4419-9fb5-69ae32706542,
  abstract     = {{In the process of obtaining a driver's license, a healthy 28year old man presented increased levels of disialo-transferrin (TF) (approx. 20%, ref. value&lt;2) by HPLC analysis of TF isoforms (%CDT), while other markers of excessive alcohol consumption (PEth, MCV and γ-GT) were in the normal range. The objective of this study was to determine the cause of the increased %CDT levels.}},
  author       = {{Grahn, Ammi and Bengtson, Per and Eklund, Erik and Asin-Cayuela, Jorge}},
  issn         = {{1873-2933}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{511--513}},
  publisher    = {{Elsevier}},
  series       = {{Clinical Biochemistry}},
  title        = {{A novel mutation on the transferrin gene abolishes one N-glycosylation site and alters the pattern of transferrin isoforms, mimicking that observed after excessive alcohol consumption.}},
  url          = {{http://dx.doi.org/10.1016/j.clinbiochem.2015.12.001}},
  doi          = {{10.1016/j.clinbiochem.2015.12.001}},
  volume       = {{49}},
  year         = {{2016}},
}