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Normal reference interval for thyrotropin response to thyroliberin : dependence on age, sex, free thyroxin index, and basal concentrations of thyrotropin

Erfurth, E M LU ; Nordén, N E LU ; Hedner, P ; Nilsson, A and Ek, L LU (1984) In Clinical Chemistry 30(2). p.9-196
Abstract

We measured the thyrotropin response (delta TSH) to 200 micrograms of thyroliberin in 131 subjects without thyroid dysfunction or other disease and with basal values for thyroid function that were within the normal reference intervals for our laboratory. By univariate and multivariate statistical methods we found delta TSH to be significantly influenced by the basal concentration of thyrotropin (TSH0) and the free thyroxin index (FT4I). When the effects of variations in TSH0 and FT4I were eliminated, delta TSH in men under 40 years of age did not differ from that in women. A decrease in delta TSH with increasing age was found in men but not in women. Thus a reference interval for delta TSH should consider TSH0, FT4I, and, in men, age.... (More)

We measured the thyrotropin response (delta TSH) to 200 micrograms of thyroliberin in 131 subjects without thyroid dysfunction or other disease and with basal values for thyroid function that were within the normal reference intervals for our laboratory. By univariate and multivariate statistical methods we found delta TSH to be significantly influenced by the basal concentration of thyrotropin (TSH0) and the free thyroxin index (FT4I). When the effects of variations in TSH0 and FT4I were eliminated, delta TSH in men under 40 years of age did not differ from that in women. A decrease in delta TSH with increasing age was found in men but not in women. Thus a reference interval for delta TSH should consider TSH0, FT4I, and, in men, age. On the basis of multiple linear regression analysis, we constructed a formula for delta TSH reference intervals that takes into account individual values for TSH0 and FT4I. The formula should be applicable for women, regardless of age, up to 77 years and for men under 40 years. For older men a correction for the age-related decrease in delta TSH must be applied.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Age Factors, Aged, Aging, Female, Humans, Male, Middle Aged, Reference Values, Regression Analysis, Sex Factors, Thyroid Diseases/diagnosis, Thyrotropin/blood, Thyrotropin-Releasing Hormone, Thyroxine/metabolism
in
Clinical Chemistry
volume
30
issue
2
pages
9 - 196
publisher
American Association for Clinical Chemistry
external identifiers
  • scopus:0021348382
  • pmid:6420087
ISSN
0009-9147
language
English
LU publication?
no
id
d78c9339-589b-4634-8e39-9a5950f1dbde
date added to LUP
2023-11-27 11:11:58
date last changed
2024-01-10 11:55:52
@article{d78c9339-589b-4634-8e39-9a5950f1dbde,
  abstract     = {{<p>We measured the thyrotropin response (delta TSH) to 200 micrograms of thyroliberin in 131 subjects without thyroid dysfunction or other disease and with basal values for thyroid function that were within the normal reference intervals for our laboratory. By univariate and multivariate statistical methods we found delta TSH to be significantly influenced by the basal concentration of thyrotropin (TSH0) and the free thyroxin index (FT4I). When the effects of variations in TSH0 and FT4I were eliminated, delta TSH in men under 40 years of age did not differ from that in women. A decrease in delta TSH with increasing age was found in men but not in women. Thus a reference interval for delta TSH should consider TSH0, FT4I, and, in men, age. On the basis of multiple linear regression analysis, we constructed a formula for delta TSH reference intervals that takes into account individual values for TSH0 and FT4I. The formula should be applicable for women, regardless of age, up to 77 years and for men under 40 years. For older men a correction for the age-related decrease in delta TSH must be applied.</p>}},
  author       = {{Erfurth, E M and Nordén, N E and Hedner, P and Nilsson, A and Ek, L}},
  issn         = {{0009-9147}},
  keywords     = {{Adult; Age Factors; Aged; Aging; Female; Humans; Male; Middle Aged; Reference Values; Regression Analysis; Sex Factors; Thyroid Diseases/diagnosis; Thyrotropin/blood; Thyrotropin-Releasing Hormone; Thyroxine/metabolism}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{9--196}},
  publisher    = {{American Association for Clinical Chemistry}},
  series       = {{Clinical Chemistry}},
  title        = {{Normal reference interval for thyrotropin response to thyroliberin : dependence on age, sex, free thyroxin index, and basal concentrations of thyrotropin}},
  volume       = {{30}},
  year         = {{1984}},
}