Advanced

Frequent intratype neutralization by plasma immunoglobulin A identified in HIV-2 infection.

Özkaya Sahin, Gülsen LU ; Månsson, Fredrik LU ; Palm, Angelica LU ; Vincic, Elzbieta LU ; da Silva, Zacarias ; Medstrand, Patrik LU ; Norrgren, Hans LU ; Fenyö, Eva Maria LU and Jansson, Marianne LU (2013) In AIDS Research and Human Retroviruses 29(3). p.470-478
Abstract
Human immunodeficiency virus type 2 (HIV-2) is less transmissible and less pathogenic compared to HIV-1 and, when matched for CD4+ T cell count, the plasma viral load in HIV-2 infected individuals is approximately one log lower than in HIV-1 infected individuals. The explanation for these observations is elusive, but differences in virus controlling immunity generated in the two infections may be contributing factors. In the present study, we investigated neutralization by immunoglobulin A (IgA), in parallel with IgG, purified from plasma of HIV-1, HIV-2 and HIV-1/HIV-2 dually (HIV-D)-infected individuals. Neutralization was analyzed against HIV-1 and HIV-2 isolates using a plaque reduction assay. In HIV-2 infection, intratype-specific... (More)
Human immunodeficiency virus type 2 (HIV-2) is less transmissible and less pathogenic compared to HIV-1 and, when matched for CD4+ T cell count, the plasma viral load in HIV-2 infected individuals is approximately one log lower than in HIV-1 infected individuals. The explanation for these observations is elusive, but differences in virus controlling immunity generated in the two infections may be contributing factors. In the present study, we investigated neutralization by immunoglobulin A (IgA), in parallel with IgG, purified from plasma of HIV-1, HIV-2 and HIV-1/HIV-2 dually (HIV-D)-infected individuals. Neutralization was analyzed against HIV-1 and HIV-2 isolates using a plaque reduction assay. In HIV-2 infection, intratype-specific neutralization by IgA was frequently detected, although at a lesser magnitude then the corresponding IgG neutralizing titers. In contrast, neutralization by IgA could rarely be demonstrated in HIV-1 infection despite similar plasma IgA levels in both infections. In addition, IgA and IgG of HIV-D plasma neutralized the HIV-2 isolate more potently than the HIV-1 isolate, suggesting that the difference between neutralizing activity of plasma IgA and IgG depends on the virus itself. Taken together, these findings suggest that both IgA and IgG adds to the potent intratype neutralizing activity detected in HIV-2 plasma, which may contribute to virus control in HIV-2 infection. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
AIDS Research and Human Retroviruses
volume
29
issue
3
pages
470 - 478
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000315434000010
  • pmid:23088167
  • scopus:84874475177
  • pmid:23088167
ISSN
1931-8405
DOI
10.1089/AID.2012.0219
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (SUS) (013008000), Clinical Microbiology, Malmö (013011000), Division of Medical Microbiology (013250400), Faculty of Medicine (000022000), Clinical Virology, Malmö (013017580), Infectious Diseases Research Unit (013242010), Molecular Virology (013212007), Division of Hematology and Transfusion Medicine (013041100)
id
d7ff4ac4-a7e0-4654-b5bf-a2444b26ebb5 (old id 3160471)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23088167?dopt=Abstract
date added to LUP
2016-04-01 09:57:21
date last changed
2020-01-05 03:49:48
@article{d7ff4ac4-a7e0-4654-b5bf-a2444b26ebb5,
  abstract     = {Human immunodeficiency virus type 2 (HIV-2) is less transmissible and less pathogenic compared to HIV-1 and, when matched for CD4+ T cell count, the plasma viral load in HIV-2 infected individuals is approximately one log lower than in HIV-1 infected individuals. The explanation for these observations is elusive, but differences in virus controlling immunity generated in the two infections may be contributing factors. In the present study, we investigated neutralization by immunoglobulin A (IgA), in parallel with IgG, purified from plasma of HIV-1, HIV-2 and HIV-1/HIV-2 dually (HIV-D)-infected individuals. Neutralization was analyzed against HIV-1 and HIV-2 isolates using a plaque reduction assay. In HIV-2 infection, intratype-specific neutralization by IgA was frequently detected, although at a lesser magnitude then the corresponding IgG neutralizing titers. In contrast, neutralization by IgA could rarely be demonstrated in HIV-1 infection despite similar plasma IgA levels in both infections. In addition, IgA and IgG of HIV-D plasma neutralized the HIV-2 isolate more potently than the HIV-1 isolate, suggesting that the difference between neutralizing activity of plasma IgA and IgG depends on the virus itself. Taken together, these findings suggest that both IgA and IgG adds to the potent intratype neutralizing activity detected in HIV-2 plasma, which may contribute to virus control in HIV-2 infection.},
  author       = {Özkaya Sahin, Gülsen and Månsson, Fredrik and Palm, Angelica and Vincic, Elzbieta and da Silva, Zacarias and Medstrand, Patrik and Norrgren, Hans and Fenyö, Eva Maria and Jansson, Marianne},
  issn         = {1931-8405},
  language     = {eng},
  number       = {3},
  pages        = {470--478},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {AIDS Research and Human Retroviruses},
  title        = {Frequent intratype neutralization by plasma immunoglobulin A identified in HIV-2 infection.},
  url          = {https://lup.lub.lu.se/search/ws/files/1422877/3165472.pdf},
  doi          = {10.1089/AID.2012.0219},
  volume       = {29},
  year         = {2013},
}