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Tobacco smoke and bladder cancer-in the European prospective investigation into cancer and nutrition

Bjerregaard, Bine Kjoller ; Raaschou-Nielsen, Ole ; Sorensen, Mette ; Frederiksen, Kirsten ; Christensen, Jane ; Tjonneland, Anne ; Overvad, Kim ; Chapelon, Francoise Clavel ; Nagel, Gabriele and Chang-Claude, Jenny , et al. (2006) In International Journal of Cancer 119(10). p.2412-2416
Abstract
The purpose of the present study was to investigate the association between smoking and the development of bladder cancer. The study population consisted of 429,906 persons participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), 633 of whom developed bladder cancer during the follow-up period. An increased risk of bladder cancer was found for both current- (incidence rate ratio 3.96, 95% confidence interval: 3.07-5.09) and ex- (2.25, 1.74-2.91) smokers, compared to never-smokers. A positive association with intensity (per 5 cigarettes) was found among current-smokers (1.18, 1.09-1.28). Associations (per 5 years) were observed for duration (1.14, 1.08-1.21), later age at start (0.75, 0.66-0.85) and longer... (More)
The purpose of the present study was to investigate the association between smoking and the development of bladder cancer. The study population consisted of 429,906 persons participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), 633 of whom developed bladder cancer during the follow-up period. An increased risk of bladder cancer was found for both current- (incidence rate ratio 3.96, 95% confidence interval: 3.07-5.09) and ex- (2.25, 1.74-2.91) smokers, compared to never-smokers. A positive association with intensity (per 5 cigarettes) was found among current-smokers (1.18, 1.09-1.28). Associations (per 5 years) were observed for duration (1.14, 1.08-1.21), later age at start (0.75, 0.66-0.85) and longer time since quitting (0.92, 0.86-0.98). Exposure to environmental tobacco smoke (ETS) during childhood increased the risk of bladder cancer (1.38, 1.00-1.90), whereas for ETS exposure as adult no effect was detected. The present study confirms the strong association between smoking and bladder cancer. The indication of a higher risk of bladder cancer for those who start smoking at a young age and for those exposed to ETS during childhood adds to the body of evidence suggesting that children are more sensitive to carcinogens than adults. (c) 2006 Wiley-Liss, Inc. (Less)
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publication status
published
subject
keywords
tobacco smoke, epidemiology, bladder neoplasm, cohort study
in
International Journal of Cancer
volume
119
issue
10
pages
2412 - 2416
publisher
John Wiley & Sons
external identifiers
  • wos:000241222300024
  • pmid:16894557
  • scopus:33749625270
ISSN
0020-7136
DOI
10.1002/ijc.22169
language
English
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yes
id
d81583ee-b251-4af8-a18d-b19b9230520e (old id 388034)
date added to LUP
2016-04-01 12:16:33
date last changed
2019-07-02 01:56:46
@article{d81583ee-b251-4af8-a18d-b19b9230520e,
  abstract     = {The purpose of the present study was to investigate the association between smoking and the development of bladder cancer. The study population consisted of 429,906 persons participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), 633 of whom developed bladder cancer during the follow-up period. An increased risk of bladder cancer was found for both current- (incidence rate ratio 3.96, 95% confidence interval: 3.07-5.09) and ex- (2.25, 1.74-2.91) smokers, compared to never-smokers. A positive association with intensity (per 5 cigarettes) was found among current-smokers (1.18, 1.09-1.28). Associations (per 5 years) were observed for duration (1.14, 1.08-1.21), later age at start (0.75, 0.66-0.85) and longer time since quitting (0.92, 0.86-0.98). Exposure to environmental tobacco smoke (ETS) during childhood increased the risk of bladder cancer (1.38, 1.00-1.90), whereas for ETS exposure as adult no effect was detected. The present study confirms the strong association between smoking and bladder cancer. The indication of a higher risk of bladder cancer for those who start smoking at a young age and for those exposed to ETS during childhood adds to the body of evidence suggesting that children are more sensitive to carcinogens than adults. (c) 2006 Wiley-Liss, Inc.},
  author       = {Bjerregaard, Bine Kjoller and Raaschou-Nielsen, Ole and Sorensen, Mette and Frederiksen, Kirsten and Christensen, Jane and Tjonneland, Anne and Overvad, Kim and Chapelon, Francoise Clavel and Nagel, Gabriele and Chang-Claude, Jenny and Bergmann, Manuela M. and Boeing, Heiner and Trichopoulos, Dimitrios and Trichopoulou, Antonia and Oikonomou, Eleni and Berrino, Franco and Palli, Domenico and Tumino, Rosario and Vineis, Paolo and Panico, Salvatore and Peeters, Petra H. M. and Bueno-de-Mesquita, H. Bas and Kiemeney, Lambertus and Gram, Inger Torhild and Braaten, Tonje and Lund, Eiliv and Gonzalez, Carlos A. and Berglund, Göran and Allen, Naomi and Roddam, Andrew and Bingham, Sheila and Riboli, Elio},
  issn         = {0020-7136},
  language     = {eng},
  number       = {10},
  pages        = {2412--2416},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Tobacco smoke and bladder cancer-in the European prospective investigation into cancer and nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.22169},
  doi          = {10.1002/ijc.22169},
  volume       = {119},
  year         = {2006},
}