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Stem cell-based therapy for malignant glioma.

Bexell, Daniel LU ; Svensson, Andreas LU and Bengzon, Johan LU (2013) In Cancer Treatment Reviews 39(4). p.358-365
Abstract
Stem cells have been extensively investigated as tumour-tropic vectors for gene delivery to solid tumours. In this review, we discuss the potential for using stem cells as cellular vector systems in gene therapy for malignant gliomas, with a focus on neural stem cells, and multipotent mesenchymal stromal cells. Tumour cell-derived substances and factors associated with tumour-induced inflammation and tumour neovascularisation can specifically attract stem cells to invasive gliomas. Injected stem cells engineered to produce anti-tumour substances have shown strong therapeutic effects in experimental glioma models. However, the potential caveats include the immunosuppressive functions of multipotent mesenchymal stromal cells, the... (More)
Stem cells have been extensively investigated as tumour-tropic vectors for gene delivery to solid tumours. In this review, we discuss the potential for using stem cells as cellular vector systems in gene therapy for malignant gliomas, with a focus on neural stem cells, and multipotent mesenchymal stromal cells. Tumour cell-derived substances and factors associated with tumour-induced inflammation and tumour neovascularisation can specifically attract stem cells to invasive gliomas. Injected stem cells engineered to produce anti-tumour substances have shown strong therapeutic effects in experimental glioma models. However, the potential caveats include the immunosuppressive functions of multipotent mesenchymal stromal cells, the contribution of stem cells to the pro-tumourigenic stroma, and the malignant transformation of implanted stem cells. In addition, it is not yet known which stem cell types and therapeutic genes will be most effective for the treatment of glioma patients. Here, we highlight the possibilities and problems for translating promising experimental findings in glioma models into the clinic. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Treatment Reviews
volume
39
issue
4
pages
358 - 365
publisher
WB Saunders
external identifiers
  • wos:000317709300007
  • pmid:22795538
  • scopus:84875503789
ISSN
1532-1967
DOI
10.1016/j.ctrv.2012.06.006
language
English
LU publication?
yes
id
d91af2f4-fcb7-4314-afb9-e9da2918df6f (old id 2967156)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22795538?dopt=Abstract
date added to LUP
2012-08-09 18:27:54
date last changed
2019-05-21 01:39:44
@article{d91af2f4-fcb7-4314-afb9-e9da2918df6f,
  abstract     = {Stem cells have been extensively investigated as tumour-tropic vectors for gene delivery to solid tumours. In this review, we discuss the potential for using stem cells as cellular vector systems in gene therapy for malignant gliomas, with a focus on neural stem cells, and multipotent mesenchymal stromal cells. Tumour cell-derived substances and factors associated with tumour-induced inflammation and tumour neovascularisation can specifically attract stem cells to invasive gliomas. Injected stem cells engineered to produce anti-tumour substances have shown strong therapeutic effects in experimental glioma models. However, the potential caveats include the immunosuppressive functions of multipotent mesenchymal stromal cells, the contribution of stem cells to the pro-tumourigenic stroma, and the malignant transformation of implanted stem cells. In addition, it is not yet known which stem cell types and therapeutic genes will be most effective for the treatment of glioma patients. Here, we highlight the possibilities and problems for translating promising experimental findings in glioma models into the clinic.},
  author       = {Bexell, Daniel and Svensson, Andreas and Bengzon, Johan},
  issn         = {1532-1967},
  language     = {eng},
  number       = {4},
  pages        = {358--365},
  publisher    = {WB Saunders},
  series       = {Cancer Treatment Reviews},
  title        = {Stem cell-based therapy for malignant glioma.},
  url          = {http://dx.doi.org/10.1016/j.ctrv.2012.06.006},
  volume       = {39},
  year         = {2013},
}