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Acoustic focusing of microparticles in two-phase systems - Towards cell enrichment or medium exchange in droplets

Fornell, Anna LU ; Jonsson, Håkan N.; Nilsson, Johan and Tenje, Maria LU (2015) 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences p.1026-1028
Abstract

We present a method to first laterally position microparticles inside droplets by acoustic forces and then split the droplet into three daughter droplets to achieve a 2+fold enrichment of microparticles inside the center droplet. We show that acoustic forces can be applied to both manipulate polystyrene beads (5 μm) and red blood cells inside droplets. The presented technology opens up for development of droplet operations used for medium exchange and particle concentration in droplet-based cell assays.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Droplet microfluidics, Integrated acoustics, Ultrasound
in
MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
pages
3 pages
publisher
Chemical and Biological Microsystems Society
conference name
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
external identifiers
  • scopus:84983266550
ISBN
9780979806483
language
English
LU publication?
yes
id
d94559d0-77ba-4d09-b44a-518a5d39fb0a
date added to LUP
2016-12-20 15:05:17
date last changed
2017-01-01 08:44:06
@inproceedings{d94559d0-77ba-4d09-b44a-518a5d39fb0a,
  abstract     = {<p>We present a method to first laterally position microparticles inside droplets by acoustic forces and then split the droplet into three daughter droplets to achieve a 2+fold enrichment of microparticles inside the center droplet. We show that acoustic forces can be applied to both manipulate polystyrene beads (5 μm) and red blood cells inside droplets. The presented technology opens up for development of droplet operations used for medium exchange and particle concentration in droplet-based cell assays.</p>},
  author       = {Fornell, Anna and Jonsson, Håkan N. and Nilsson, Johan and Tenje, Maria},
  booktitle    = {MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences},
  isbn         = {9780979806483},
  keyword      = {Droplet microfluidics,Integrated acoustics,Ultrasound},
  language     = {eng},
  pages        = {1026--1028},
  publisher    = {Chemical and Biological Microsystems Society},
  title        = {Acoustic focusing of microparticles in two-phase systems - Towards cell enrichment or medium exchange in droplets},
  year         = {2015},
}