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Clinical associations with venous thromboembolism in anti-neutrophil cytoplasm antibody-associated vasculitides

Kronbichler, Andreas; Leierer, Johannes; Leierer, Gisela; Mayer, Gert; Casian, Alina; Höglund, Peter LU ; Westman, Kerstin LU and Jayne, David (2017) In Rheumatology 56(5). p.704-708
Abstract

Objective. To assess potential associations for the development of venous thromboembolic events in patients with ANCA-associated vasculitides (AAV). Methods. Four hundred and seventeen patients enrolled to participate in randomized controlled trials conducted by the European Vasculitis Society were identified. Univariate and multivariate analyses were performed to validate previously proposed and identify novel risks associated with venous thromboembolism (VTE) in AAV. Results. VTE occurred in 41 of 417 (9.8%) patients. Uncorrected univariate analysis identified BVAS (odds ratio, OR= 1.05, 95% CI: 1.01, 1.10; P = 0.013), subsequent development of malignancy (OR = 2.6, 95% CI: 1.19, 5.71; P = 0.017), mucous membrane or eye involvement... (More)

Objective. To assess potential associations for the development of venous thromboembolic events in patients with ANCA-associated vasculitides (AAV). Methods. Four hundred and seventeen patients enrolled to participate in randomized controlled trials conducted by the European Vasculitis Society were identified. Univariate and multivariate analyses were performed to validate previously proposed and identify novel risks associated with venous thromboembolism (VTE) in AAV. Results. VTE occurred in 41 of 417 (9.8%) patients. Uncorrected univariate analysis identified BVAS (odds ratio, OR= 1.05, 95% CI: 1.01, 1.10; P = 0.013), subsequent development of malignancy (OR = 2.6, 95% CI: 1.19, 5.71; P = 0.017), mucous membrane or eye involvement (OR = 2.13, 95% CI: 1.10, 4.11; P = 0.024) and baseline creatinine (OR = 1.08, 95% CI: 0.99, 1.18; P = 0.037) as being associated with the development of VTE. Multivariate analysis highlighted CRP (per 10 mg/l increase, OR= 1.05, 95% CI: 1.01, 1.09; P = 0.025), cutaneous involvement (OR = 4.83, 95% CI: 1.63, 14.38; P = 0.005) and gastrointestinal involvement (OR = 6.27, 95% CI: 1.34, 29.37; P = 0.02) among the BVAS items as well as baseline creatinine (per 100 mmol/l increase, OR= 1.17, 95% CI: 1.02, 1.35; P = 0.029) as being associated with VTEs. Conclusion. Our results highlight a role of CRP, baseline creatinine, and cutaneous and gastrointestinal involvement in the risk stratification as being associated with thromboembolic events. Moreover, there might be an association between VTEs and subsequent development of malignancy and disease activity in general.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ANCA, Deep venous thrombosis, Malignancy, Pulmonary embolism, Vasculitis, Venous thromboembolism
in
Rheumatology
volume
56
issue
5
pages
5 pages
publisher
Oxford University Press
external identifiers
  • scopus:85019675192
  • wos:000402143000007
ISSN
1462-0324
DOI
10.1093/rheumatology/kew465
language
English
LU publication?
yes
id
d96aeb07-0529-4397-b1fc-213e0c48252a
date added to LUP
2017-07-03 16:43:11
date last changed
2017-09-18 11:37:21
@article{d96aeb07-0529-4397-b1fc-213e0c48252a,
  abstract     = {<p>Objective. To assess potential associations for the development of venous thromboembolic events in patients with ANCA-associated vasculitides (AAV). Methods. Four hundred and seventeen patients enrolled to participate in randomized controlled trials conducted by the European Vasculitis Society were identified. Univariate and multivariate analyses were performed to validate previously proposed and identify novel risks associated with venous thromboembolism (VTE) in AAV. Results. VTE occurred in 41 of 417 (9.8%) patients. Uncorrected univariate analysis identified BVAS (odds ratio, OR= 1.05, 95% CI: 1.01, 1.10; P = 0.013), subsequent development of malignancy (OR = 2.6, 95% CI: 1.19, 5.71; P = 0.017), mucous membrane or eye involvement (OR = 2.13, 95% CI: 1.10, 4.11; P = 0.024) and baseline creatinine (OR = 1.08, 95% CI: 0.99, 1.18; P = 0.037) as being associated with the development of VTE. Multivariate analysis highlighted CRP (per 10 mg/l increase, OR= 1.05, 95% CI: 1.01, 1.09; P = 0.025), cutaneous involvement (OR = 4.83, 95% CI: 1.63, 14.38; P = 0.005) and gastrointestinal involvement (OR = 6.27, 95% CI: 1.34, 29.37; P = 0.02) among the BVAS items as well as baseline creatinine (per 100 mmol/l increase, OR= 1.17, 95% CI: 1.02, 1.35; P = 0.029) as being associated with VTEs. Conclusion. Our results highlight a role of CRP, baseline creatinine, and cutaneous and gastrointestinal involvement in the risk stratification as being associated with thromboembolic events. Moreover, there might be an association between VTEs and subsequent development of malignancy and disease activity in general.</p>},
  author       = {Kronbichler, Andreas and Leierer, Johannes and Leierer, Gisela and Mayer, Gert and Casian, Alina and Höglund, Peter and Westman, Kerstin and Jayne, David},
  issn         = {1462-0324},
  keyword      = {ANCA,Deep venous thrombosis,Malignancy,Pulmonary embolism,Vasculitis,Venous thromboembolism},
  language     = {eng},
  month        = {05},
  number       = {5},
  pages        = {704--708},
  publisher    = {Oxford University Press},
  series       = {Rheumatology},
  title        = {Clinical associations with venous thromboembolism in anti-neutrophil cytoplasm antibody-associated vasculitides},
  url          = {http://dx.doi.org/10.1093/rheumatology/kew465},
  volume       = {56},
  year         = {2017},
}