Prenatal exposure to bisphenols and cognitive function in children at 7 years of age in the Swedish SELMA study
Bornehag, Carl Gustaf LU ; Engdahl, Elin ; Unenge Hallerbäck, Maria ; Wikström, Sverre ; Lindh, Christian LU
; Rüegg, Joëlle
; Tanner, Eva
and Gennings, Chris
(2021)
In Environment International
150.
- Abstract
Background: Experimental evidence demonstrates that exposure to bisphenol A (BPA), and the recently introduced alternatives bisphenol S (BPS) and bisphenol F (BPF) alter normal neurodevelopment. More research is needed to evaluate the associations between exposure to individual BPA alternatives and neurodevelopmental outcomes in humans. Objective: The present study aimed at examining the individual associations between prenatal BPA, BPS and BPF exposure and cognitive outcomes in children at age 7 years. Method: Women were enrolled in the Swedish Environmental Longitudinal Mother and Child, Asthma and Allergy (SELMA) study, at gestational median week 10.0, and their children were examined for cognitive function at 7 years of age (N =... (More)
Background: Experimental evidence demonstrates that exposure to bisphenol A (BPA), and the recently introduced alternatives bisphenol S (BPS) and bisphenol F (BPF) alter normal neurodevelopment. More research is needed to evaluate the associations between exposure to individual BPA alternatives and neurodevelopmental outcomes in humans. Objective: The present study aimed at examining the individual associations between prenatal BPA, BPS and BPF exposure and cognitive outcomes in children at age 7 years. Method: Women were enrolled in the Swedish Environmental Longitudinal Mother and Child, Asthma and Allergy (SELMA) study, at gestational median week 10.0, and their children were examined for cognitive function at 7 years of age (N = 803). Maternal urinary BPA, BPS, and BPF concentrations were measured at enrollment and childreńs cognitive function at the age of 7 years was measured using the Wechsler Intelligence Scale for Children IV (WISC-IV). Results: All three bisphenols were detected in over 90% of the women, where BPA had the highest geometric mean concentrations (1.55 ng/mL), followed by BPF (0.16 ng/mL) and BPS (0.07 ng/mL). Prenatal BPF exposure was associated with decreased full scale IQ (β = −1.96, 95%CI; −3.12; −0.80), as well as with a decrease in all four sub scales covering verbal comprehension, perceptual reasoning, working memory and processing speed. This association corresponded to a 1.6-point lower IQ score for an inter-quartile-range (IQR) change in prenatal BPF exposure (IQR = 0.054–0.350 ng/mL). In sex-stratified analyses, significant associations with full scale IQ were found for boys (β = −2.86, 95%CI; −4.54; −1.18), while the associations for girls did not reach significance (β = −1.38, 95%CI; −2.97; 0.22). No significant associations between BPA nor BPS and cognition were found. Discussion: Prenatal exposure to BPF was significantly associated with childreńs cognitive function at 7 years. Since BPF is replacing BPA in numerous consumer products globally, this finding urgently call for further studies.
(Less)
- author
- Bornehag, Carl Gustaf
LU
; Engdahl, Elin
; Unenge Hallerbäck, Maria
; Wikström, Sverre
; Lindh, Christian
LU
; Rüegg, Joëlle
; Tanner, Eva
and Gennings, Chris
- organization
- publishing date
- 2021-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bisphenols, BPA, BPF, BPS, Cognitive function, Prenatal exposure
- in
- Environment International
- volume
- 150
- article number
- 106433
- publisher
- Elsevier
- external identifiers
-
- scopus:85101933645
- pmid:33637302
- ISSN
- 0160-4120
- DOI
- 10.1016/j.envint.2021.106433
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021
- id
- d9910dc8-b419-4990-b681-d56b45b7e36c
- date added to LUP
- 2021-12-20 11:55:55
- date last changed
- 2024-05-04 19:03:34
@article{d9910dc8-b419-4990-b681-d56b45b7e36c,
abstract = {{<p>Background: Experimental evidence demonstrates that exposure to bisphenol A (BPA), and the recently introduced alternatives bisphenol S (BPS) and bisphenol F (BPF) alter normal neurodevelopment. More research is needed to evaluate the associations between exposure to individual BPA alternatives and neurodevelopmental outcomes in humans. Objective: The present study aimed at examining the individual associations between prenatal BPA, BPS and BPF exposure and cognitive outcomes in children at age 7 years. Method: Women were enrolled in the Swedish Environmental Longitudinal Mother and Child, Asthma and Allergy (SELMA) study, at gestational median week 10.0, and their children were examined for cognitive function at 7 years of age (N = 803). Maternal urinary BPA, BPS, and BPF concentrations were measured at enrollment and childreńs cognitive function at the age of 7 years was measured using the Wechsler Intelligence Scale for Children IV (WISC-IV). Results: All three bisphenols were detected in over 90% of the women, where BPA had the highest geometric mean concentrations (1.55 ng/mL), followed by BPF (0.16 ng/mL) and BPS (0.07 ng/mL). Prenatal BPF exposure was associated with decreased full scale IQ (β = −1.96, 95%CI; −3.12; −0.80), as well as with a decrease in all four sub scales covering verbal comprehension, perceptual reasoning, working memory and processing speed. This association corresponded to a 1.6-point lower IQ score for an inter-quartile-range (IQR) change in prenatal BPF exposure (IQR = 0.054–0.350 ng/mL). In sex-stratified analyses, significant associations with full scale IQ were found for boys (β = −2.86, 95%CI; −4.54; −1.18), while the associations for girls did not reach significance (β = −1.38, 95%CI; −2.97; 0.22). No significant associations between BPA nor BPS and cognition were found. Discussion: Prenatal exposure to BPF was significantly associated with childreńs cognitive function at 7 years. Since BPF is replacing BPA in numerous consumer products globally, this finding urgently call for further studies.</p>}},
author = {{Bornehag, Carl Gustaf and Engdahl, Elin and Unenge Hallerbäck, Maria and Wikström, Sverre and Lindh, Christian and Rüegg, Joëlle and Tanner, Eva and Gennings, Chris}},
issn = {{0160-4120}},
keywords = {{Bisphenols; BPA; BPF; BPS; Cognitive function; Prenatal exposure}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Environment International}},
title = {{Prenatal exposure to bisphenols and cognitive function in children at 7 years of age in the Swedish SELMA study}},
url = {{http://dx.doi.org/10.1016/j.envint.2021.106433}},
doi = {{10.1016/j.envint.2021.106433}},
volume = {{150}},
year = {{2021}},
}