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Methods and practices to increase the donor pool in adult lung transplantation

Niroomand, Anna LU ; Neyrinck, Arne and Lindstedt, Sandra LU (2024) In ERS Monograph 2024. p.118-134
Abstract

As advancements in transplantation techniques continue, the challenge remains the limited availability of suitable donor organs. This chapter explores strategies to expand the donor pool and optimise transplant outcomes, which include the use of extended criteria donors, living lobar transplantation, donor-to-recipient graft size matching, and innovations in hypothermic storage and ex vivo lung perfusion (EVLP). Living lobar transplantation, which is prevalent in regions with low DBD rates, offers a life-saving alternative despite its inherent risks. Donor-to-recipient graft size matching is being refined through both traditional and innovative techniques. Hypothermic storage advancements, such as controlled temperature devices, aim to... (More)

As advancements in transplantation techniques continue, the challenge remains the limited availability of suitable donor organs. This chapter explores strategies to expand the donor pool and optimise transplant outcomes, which include the use of extended criteria donors, living lobar transplantation, donor-to-recipient graft size matching, and innovations in hypothermic storage and ex vivo lung perfusion (EVLP). Living lobar transplantation, which is prevalent in regions with low DBD rates, offers a life-saving alternative despite its inherent risks. Donor-to-recipient graft size matching is being refined through both traditional and innovative techniques. Hypothermic storage advancements, such as controlled temperature devices, aim to extend organ viability. EVLP preserves and rehabilitates marginal organs, offering new possibilities for gene and cell therapy. The integration of artificial intelligence in EVLP assessments further enhances precision in evaluating organ suitability, paving the way for safer and more effective transplant procedures. Standard measures related to clear donor detection pathways and optimisation of donor management also remain valid strategies to be improved.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Lung Transplantation
series title
ERS Monograph
editor
Perch, M ; Meloni, F and Lindstedt, S
volume
2024
edition
106
pages
118 - 134
external identifiers
  • scopus:85217843031
ISSN
2312-508X
DOI
10.1183/2312508X.10001724
language
English
LU publication?
yes
additional info
Publisher Copyright: © ERS 2024.
id
d9edc243-d50c-499a-9079-4cc87cda2be8
date added to LUP
2025-04-02 09:48:01
date last changed
2025-04-04 15:28:45
@inbook{d9edc243-d50c-499a-9079-4cc87cda2be8,
  abstract     = {{<p>As advancements in transplantation techniques continue, the challenge remains the limited availability of suitable donor organs. This chapter explores strategies to expand the donor pool and optimise transplant outcomes, which include the use of extended criteria donors, living lobar transplantation, donor-to-recipient graft size matching, and innovations in hypothermic storage and ex vivo lung perfusion (EVLP). Living lobar transplantation, which is prevalent in regions with low DBD rates, offers a life-saving alternative despite its inherent risks. Donor-to-recipient graft size matching is being refined through both traditional and innovative techniques. Hypothermic storage advancements, such as controlled temperature devices, aim to extend organ viability. EVLP preserves and rehabilitates marginal organs, offering new possibilities for gene and cell therapy. The integration of artificial intelligence in EVLP assessments further enhances precision in evaluating organ suitability, paving the way for safer and more effective transplant procedures. Standard measures related to clear donor detection pathways and optimisation of donor management also remain valid strategies to be improved.</p>}},
  author       = {{Niroomand, Anna and Neyrinck, Arne and Lindstedt, Sandra}},
  booktitle    = {{Lung Transplantation}},
  editor       = {{Perch, M and Meloni, F and Lindstedt, S}},
  issn         = {{2312-508X}},
  language     = {{eng}},
  pages        = {{118--134}},
  series       = {{ERS Monograph}},
  title        = {{Methods and practices to increase the donor pool in adult lung transplantation}},
  url          = {{http://dx.doi.org/10.1183/2312508X.10001724}},
  doi          = {{10.1183/2312508X.10001724}},
  volume       = {{2024}},
  year         = {{2024}},
}