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The impact of socio-economic factors on treatment choice and mortality in chronic myeloid leukaemia

Larfors, Gunnar; Sandin, Fredrik; Richter, Johan LU ; Själander, Anders; Stenke, Leif; Lambe, Mats and Höglund, Martin (2017) In European Journal of Haematology1987-01-01+01:00 98(4). p.398-406
Abstract

Purpose: To evaluate the influence of socio-economic variables on treatment selection and survival of patients with chronic myeloid leukaemia (CML). Methods: Using information available in population-based Swedish registries, we evaluated indices of health, education and economy from the 980 patients in the Swedish CML register diagnosed between 2002 and 2012. Apart from internal comparisons, five age-, gender- and region-matched control subjects per patient served as control cohort. Median follow-up time from CML diagnosis was 4.8 years. Results: Among patients with CML, low personal or household income, short education, living alone, poor performance status and high age (>60 years) were significantly associated with an inferior... (More)

Purpose: To evaluate the influence of socio-economic variables on treatment selection and survival of patients with chronic myeloid leukaemia (CML). Methods: Using information available in population-based Swedish registries, we evaluated indices of health, education and economy from the 980 patients in the Swedish CML register diagnosed between 2002 and 2012. Apart from internal comparisons, five age-, gender- and region-matched control subjects per patient served as control cohort. Median follow-up time from CML diagnosis was 4.8 years. Results: Among patients with CML, low personal or household income, short education, living alone, poor performance status and high age (>60 years) were significantly associated with an inferior survival (in univariate analyses). However, similar findings were noted also in the matched control group, and in comparisons adjusted for calendar year, age and performance status, socio-economic variables were not significantly associated with CML survival. Meanwhile, both education and income were independently linked to TKI treatment overall and to upfront treatment with second-generation TKIs. Conclusions: In conclusion, socio-economic conditions were associated with survival in the studied CML cohort but these associations could be explained by differences at baseline. Meanwhile, socio-economic conditions appeared to influence treatment choice.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chronic myelogenous leukaemia, Cohort studies, Epidemiology, Mortality, Socioeconomic factors
in
European Journal of Haematology1987-01-01+01:00
volume
98
issue
4
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85010375950
  • pmid: 28009456
  • wos:000397536300014
ISSN
0902-4441
DOI
10.1111/ejh.12845
language
English
LU publication?
yes
id
da485cc8-5805-4c74-ace6-51d543906775
date added to LUP
2017-02-16 17:00:37
date last changed
2018-01-07 11:50:39
@article{da485cc8-5805-4c74-ace6-51d543906775,
  abstract     = {<p>Purpose: To evaluate the influence of socio-economic variables on treatment selection and survival of patients with chronic myeloid leukaemia (CML). Methods: Using information available in population-based Swedish registries, we evaluated indices of health, education and economy from the 980 patients in the Swedish CML register diagnosed between 2002 and 2012. Apart from internal comparisons, five age-, gender- and region-matched control subjects per patient served as control cohort. Median follow-up time from CML diagnosis was 4.8 years. Results: Among patients with CML, low personal or household income, short education, living alone, poor performance status and high age (&gt;60 years) were significantly associated with an inferior survival (in univariate analyses). However, similar findings were noted also in the matched control group, and in comparisons adjusted for calendar year, age and performance status, socio-economic variables were not significantly associated with CML survival. Meanwhile, both education and income were independently linked to TKI treatment overall and to upfront treatment with second-generation TKIs. Conclusions: In conclusion, socio-economic conditions were associated with survival in the studied CML cohort but these associations could be explained by differences at baseline. Meanwhile, socio-economic conditions appeared to influence treatment choice.</p>},
  author       = {Larfors, Gunnar and Sandin, Fredrik and Richter, Johan and Själander, Anders and Stenke, Leif and Lambe, Mats and Höglund, Martin},
  issn         = {0902-4441},
  keyword      = {Chronic myelogenous leukaemia,Cohort studies,Epidemiology,Mortality,Socioeconomic factors},
  language     = {eng},
  number       = {4},
  pages        = {398--406},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology1987-01-01+01:00},
  title        = {The impact of socio-economic factors on treatment choice and mortality in chronic myeloid leukaemia},
  url          = {http://dx.doi.org/10.1111/ejh.12845},
  volume       = {98},
  year         = {2017},
}