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Two-layer reconstruction of Raman spectra in diffusive media based on an analytical model in the time domain

Susnjar, Stefan LU ; Martelli, Fabrizio ; Mosca, Sara ; Sekar, Sanathana Konugolu Venkata ; Swartling, Johannes ; Reistad, Nina LU orcid ; Farina, Andrea and Pifferi, Antonio (2023) In Optics Express 31(24). p.40573-40591
Abstract
We derive and validate an analytical model that describes the migration of Raman scattered photons in two-layer diffusive media, based on the diffusion equation in the time domain. The model is derived under a heuristic approximation that background optical properties are identical on the excitation and Raman emission wavelengths. Methods for the reconstruction of two-layer Raman spectra have been developed, tested in computer simulations and validated on tissue-mimicking phantom measurements data. Effects of different parameters were studied in simulations, showing that the thickness of the top layer and number of detected photon counts have the most significant impact on the reconstruction. The concept of quantitative, mathematically... (More)
We derive and validate an analytical model that describes the migration of Raman scattered photons in two-layer diffusive media, based on the diffusion equation in the time domain. The model is derived under a heuristic approximation that background optical properties are identical on the excitation and Raman emission wavelengths. Methods for the reconstruction of two-layer Raman spectra have been developed, tested in computer simulations and validated on tissue-mimicking phantom measurements data. Effects of different parameters were studied in simulations, showing that the thickness of the top layer and number of detected photon counts have the most significant impact on the reconstruction. The concept of quantitative, mathematically rigorous reconstruction using the proposed model was finally proven on experimental measurements, by successfully separating the spectra of silicone and calcium carbonate (calcite) layers, showing the potential for further development and eventual application in clinical diagnostics. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Express
volume
31
issue
24
pages
40573 - 40591
publisher
Optical Society of America
external identifiers
  • scopus:85178370813
ISSN
1094-4087
DOI
10.1364/OE.504105
language
English
LU publication?
yes
id
da4e403d-0419-45fe-beba-acb8c0cab2ff
date added to LUP
2023-11-15 18:17:23
date last changed
2024-02-11 04:06:01
@article{da4e403d-0419-45fe-beba-acb8c0cab2ff,
  abstract     = {{We derive and validate an analytical model that describes the migration of Raman scattered photons in two-layer diffusive media, based on the diffusion equation in the time domain. The model is derived under a heuristic approximation that background optical properties are identical on the excitation and Raman emission wavelengths. Methods for the reconstruction of two-layer Raman spectra have been developed, tested in computer simulations and validated on tissue-mimicking phantom measurements data. Effects of different parameters were studied in simulations, showing that the thickness of the top layer and number of detected photon counts have the most significant impact on the reconstruction. The concept of quantitative, mathematically rigorous reconstruction using the proposed model was finally proven on experimental measurements, by successfully separating the spectra of silicone and calcium carbonate (calcite) layers, showing the potential for further development and eventual application in clinical diagnostics.}},
  author       = {{Susnjar, Stefan and Martelli, Fabrizio and Mosca, Sara and Sekar, Sanathana Konugolu Venkata and Swartling, Johannes and Reistad, Nina and Farina, Andrea and Pifferi, Antonio}},
  issn         = {{1094-4087}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{24}},
  pages        = {{40573--40591}},
  publisher    = {{Optical Society of America}},
  series       = {{Optics Express}},
  title        = {{Two-layer reconstruction of Raman spectra in diffusive media based on an analytical model in the time domain}},
  url          = {{http://dx.doi.org/10.1364/OE.504105}},
  doi          = {{10.1364/OE.504105}},
  volume       = {{31}},
  year         = {{2023}},
}