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No interaction between H2 blockers and isoniazid

Paulsen, Otto; Höglund, P LU ; Nilsson, L G and Gredeby, H (1986) In European Journal of Respiratory Diseases 68(4). p.90-286
Abstract

Antacids and anticholinergic drugs may delay gastric emptying and cause reduced absorption of isoniazid, but the influence of reduced gastric acidity has not been determined. In the present investigation, the influence of cimetidine and ranitidine on uptake and elimination of isoniazid was determined in six male and seven female healthy volunteers. The group comprised five rapid and eight slow acetylators, similar to the proportions in the general population. H2 blockers did not delay or reduce uptake of isoniazid, which thus seemed to be pH independent. Neither the acetylation of isoniazid nor the oxidative metabolism of acetylated isoniazid appeared to be affected by cimetidine or ranitidine.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Absorption, Acetylation, Adult, Chromatography, High Pressure Liquid, Cimetidine, Drug Interactions, Female, Half-Life, Histamine H2 Antagonists, Humans, Isoniazid, Kinetics, Male, Middle Aged, Ranitidine, Spectrophotometry, Time Factors, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
in
European Journal of Respiratory Diseases
volume
68
issue
4
pages
90 - 286
publisher
Munksgaard International Publishers
external identifiers
  • scopus:0022556731
ISSN
0106-4339
language
English
LU publication?
yes
id
da92e6bc-366d-4daa-8b21-b1d0bcb62aca
date added to LUP
2017-09-14 23:42:03
date last changed
2017-09-19 16:04:44
@article{da92e6bc-366d-4daa-8b21-b1d0bcb62aca,
  abstract     = {<p>Antacids and anticholinergic drugs may delay gastric emptying and cause reduced absorption of isoniazid, but the influence of reduced gastric acidity has not been determined. In the present investigation, the influence of cimetidine and ranitidine on uptake and elimination of isoniazid was determined in six male and seven female healthy volunteers. The group comprised five rapid and eight slow acetylators, similar to the proportions in the general population. H2 blockers did not delay or reduce uptake of isoniazid, which thus seemed to be pH independent. Neither the acetylation of isoniazid nor the oxidative metabolism of acetylated isoniazid appeared to be affected by cimetidine or ranitidine.</p>},
  author       = {Paulsen, Otto and Höglund, P and Nilsson, L G and Gredeby, H},
  issn         = {0106-4339},
  keyword      = {Absorption,Acetylation,Adult,Chromatography, High Pressure Liquid,Cimetidine,Drug Interactions,Female,Half-Life,Histamine H2 Antagonists,Humans,Isoniazid,Kinetics,Male,Middle Aged,Ranitidine,Spectrophotometry,Time Factors,Comparative Study,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {4},
  pages        = {90--286},
  publisher    = {Munksgaard International Publishers},
  series       = {European Journal of Respiratory Diseases},
  title        = {No interaction between H2 blockers and isoniazid},
  volume       = {68},
  year         = {1986},
}