No interaction between H2 blockers and isoniazid
(1986) In European Journal of Respiratory Diseases 68(4). p.90-286- Abstract
Antacids and anticholinergic drugs may delay gastric emptying and cause reduced absorption of isoniazid, but the influence of reduced gastric acidity has not been determined. In the present investigation, the influence of cimetidine and ranitidine on uptake and elimination of isoniazid was determined in six male and seven female healthy volunteers. The group comprised five rapid and eight slow acetylators, similar to the proportions in the general population. H2 blockers did not delay or reduce uptake of isoniazid, which thus seemed to be pH independent. Neither the acetylation of isoniazid nor the oxidative metabolism of acetylated isoniazid appeared to be affected by cimetidine or ranitidine.
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- author
- Paulsen, Otto ; Höglund, P LU ; Nilsson, L G and Gredeby, H
- organization
- publishing date
- 1986-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Absorption, Acetylation, Adult, Chromatography, High Pressure Liquid, Cimetidine, Drug Interactions, Female, Half-Life, Histamine H2 Antagonists, Humans, Isoniazid, Kinetics, Male, Middle Aged, Ranitidine, Spectrophotometry, Time Factors, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- in
- European Journal of Respiratory Diseases
- volume
- 68
- issue
- 4
- pages
- 90 - 286
- publisher
- European Respiratory Society
- external identifiers
-
- scopus:0022556731
- pmid:2874048
- ISSN
- 0106-4339
- language
- English
- LU publication?
- yes
- id
- da92e6bc-366d-4daa-8b21-b1d0bcb62aca
- date added to LUP
- 2017-09-14 23:42:03
- date last changed
- 2024-01-14 05:12:05
@article{da92e6bc-366d-4daa-8b21-b1d0bcb62aca, abstract = {{<p>Antacids and anticholinergic drugs may delay gastric emptying and cause reduced absorption of isoniazid, but the influence of reduced gastric acidity has not been determined. In the present investigation, the influence of cimetidine and ranitidine on uptake and elimination of isoniazid was determined in six male and seven female healthy volunteers. The group comprised five rapid and eight slow acetylators, similar to the proportions in the general population. H2 blockers did not delay or reduce uptake of isoniazid, which thus seemed to be pH independent. Neither the acetylation of isoniazid nor the oxidative metabolism of acetylated isoniazid appeared to be affected by cimetidine or ranitidine.</p>}}, author = {{Paulsen, Otto and Höglund, P and Nilsson, L G and Gredeby, H}}, issn = {{0106-4339}}, keywords = {{Absorption; Acetylation; Adult; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Female; Half-Life; Histamine H2 Antagonists; Humans; Isoniazid; Kinetics; Male; Middle Aged; Ranitidine; Spectrophotometry; Time Factors; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, number = {{4}}, pages = {{90--286}}, publisher = {{European Respiratory Society}}, series = {{European Journal of Respiratory Diseases}}, title = {{No interaction between H2 blockers and isoniazid}}, volume = {{68}}, year = {{1986}}, }